公开(公告)号：EP1147112B1

公开(公告)日：2003-10-29

申请号：EP00906998.0

申请日：2000-01-25

申请人： ABBOTT LABORATORIES

发明人： BUNNELLE, William, H. ,  CRISTINA, Daniela, Barlocco ,  DAANEN, Jerome, F. ,  DART, Michael, J. ,  MEYER, Michael, D. ,  RYTHER, Keith, B. ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  TOUPENCE, Richard, B.

IPC分类号： C07D487/08 ,  A61K31/395 ,  A61P25/00 ,  C07D471/08 ,  C07D519/00

CPC分类号： C07D471/08 ,  C07D401/08 ,  C07D487/08

摘要： Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2, and CH2CH2; Z is selected from the group consisting of CH2, CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.

公开(公告)号：EP1178982A1

公开(公告)日：2002-02-13

申请号：EP00932445.0

申请日：2000-05-15

申请人： ABBOTT LABORATORIES

发明人： SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  DAANEN, Jerome, F. ,  RYTHER, Keith, B. ,  JI, Jianguo

IPC分类号： C07D401/04 ,  A61K31/4545 ,  A61K31/4439 ,  A61P25/00

CPC分类号： C07D401/04

摘要： Heterocyclic substituted aminoazacyclic compounds of the formula (I): Z-R3, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.

公开(公告)号：EP2146985A1

公开(公告)日：2010-01-27

申请号：EP07865508.1

申请日：2007-12-12

申请人： ABBOTT LABORATORIES

发明人： LEE, Chih-hung ,  JI, Jianguo ,  LI, Tao ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  GOPALAKRISHNAN, Murali

IPC分类号： C07D413/14 ,  A61K31/4245 ,  A61P25/28

CPC分类号： C07D413/14

摘要： The invention relates to heterocyclic derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions. The heterocyclic derivatives, more particularly can be substituted oxadiazole compounds and derivatives thereof.

公开(公告)号：EP1664045A1

公开(公告)日：2006-06-07

申请号：EP04784568.0

申请日：2004-09-17

申请人： ABBOTT LABORATORIES

发明人： BASHA, Anwer ,  BUNNELLE, William, H. ,  DART, Michael, J. ,  GALLAGHER, Megan, E. ,  JI, Jianguo ,  PACE, Jennifer, M. ,  RYTHER, Keith, B. ,  TIETJE, Karin, R. ,  MORTELL, Kathleen, H. ,  NERSESIAN, Diana, L. ,  SCHRIMPF, Michael, R. ,  LI, Tao

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D471/08 ,  A61K31/435 ,  A61P25/00

CPC分类号： C07D487/08 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

公开(公告)号：EP1284976A2

公开(公告)日：2003-02-26

申请号：EP01944118.7

申请日：2001-04-27

申请人： Abbott Laboratories

发明人： SCHRIMPF, Michael, R. ,  TIETJE, Karin, R. ,  TOUPENCE, Richard, B. ,  JI, Jianguo ,  BASHA, Anwer ,  BUNNELLE, William, H. ,  DAANEN, Jerome, F. ,  PACE, Jennifer, M. ,  SIPPY, Kevin, B.

IPC分类号： C07D487/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Compounds of formula (I), pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals (nicotinic acetylcholine receptor ligands).

公开(公告)号：EP1656375B1

公开(公告)日：2011-01-19

申请号：EP04741916.3

申请日：2004-06-29

申请人： NeuroSearch A/S ,  ABBOTT LABORATORIES

发明人： PETERS, Dan ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet Ostergaard ,  AHRING, Philip K. ,  JORGENSEN, Tino Dyhring ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B.

IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P25/00

CPC分类号： C07D453/02

摘要： This invention relates to novel quinuclidine derivatives represented by Formula (II) wherein represents an optional double bond; n is 1, 2 or 3; X represents a linker selected from -O-, -O-CH2-, -O-CH2-CH2-, -S-, -SO-, -SO2-, -CH2-, -S-CH2-CH2-,-CH2-, -C(=CH2)-, -NH-, -N(alkyl)-, -C(=O)-, -C(=S)-, oo, and ss; and Y represents O, S, SO2, or NR’ wherein R’ represents hydrogen or alkyl and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

公开(公告)号：EP1926731A2

公开(公告)日：2008-06-04

申请号：EP06803813.2

申请日：2006-09-19

申请人： ABBOTT LABORATORIES

发明人： SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  ANDERSON, David, J. ,  BUNNELLE, William, H. ,  NERSESIAN, Diana, L.

IPC分类号： C07D471/18 ,  A61K31/435 ,  A61P25/00 ,  C07D487/04 ,  C07D487/08

CPC分类号： C07D487/04

摘要： The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evaluating the binding affinity to α7 nicotinic acetylcholine receptors also are described.

公开(公告)号：EP1896469A2

公开(公告)日：2008-03-12

申请号：EP06784857.2

申请日：2006-06-14

申请人： ABBOTT LABORATORIES

发明人： JI, Jianguo ,  LI, Tao ,  MORTELL, Kathleen, H. ,  SCHRIMPF, Michael, R. ,  NERSESIAN, Diana, L. ,  PAN, Liping ,  BUNNELLE, William, H.

IPC分类号： C07D453/02 ,  A61P25/28 ,  A61K31/439

CPC分类号： C07D453/02

摘要： Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N+-O-; X is O, S, -NH-, and -N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

公开(公告)号：EP1711463A2

公开(公告)日：2006-10-18

申请号：EP05712865.4

申请日：2005-02-04

申请人： ABBOTT LABORATORIES

发明人： SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  JI, Jianguo ,  LI, Tao ,  PACE, Jennifer, M. ,  BRIGGS, Clark, A. ,  BUNELLE, William, H.

IPC分类号： C07D207/08

CPC分类号： C07D207/08 ,  C07C211/31 ,  C07C217/24 ,  C07C2603/18 ,  C07C2603/26 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D209/88 ,  C07D211/22 ,  C07D211/46 ,  C07D243/08 ,  C07D295/104 ,  C07D307/91 ,  C07D311/86 ,  C07D333/76 ,  C07D451/06 ,  C07D453/02 ,  C07D487/04 ,  C07D487/08

摘要： Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.

摘要翻译： 其中A和B是胺取代侧链的式（I）化合物，各种三环核心中的Y 1和Y 2，R x是任选的取代基。 考虑式（I）的化合物和组合物以及用于治疗由包含式（I）化合物和其它三环衍生物的±7nAChR配体防止或改善的病症或病症的方法。 使用氨基取代的衍生物的方法也在本文中描述。

公开(公告)号：EP2443122A1

公开(公告)日：2012-04-25

申请号：EP10788604.6

申请日：2010-06-18

申请人： Abbott Laboratories

发明人： SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B.

IPC分类号： C07D471/18 ,  A61K31/439 ,  A61P25/00 ,  A61P29/00

CPC分类号： C07D471/18

摘要： The invention relates to compounds that are diazahomoadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.

摘要翻译： 本发明涉及二氮杂高金刚烷衍生物的化合物，包含这些化合物的组合物，以及使用这些化合物和组合物的方法。