公开(公告)号：EP1124804A1

公开(公告)日：2001-08-22

申请号：EP99953259.1

申请日：1999-10-27

申请人： ABBOTT LABORATORIES

发明人： BLACK, Lawrence, A. ,  BASHA, Anwer ,  KOLASA, Teodozyj ,  KORT, Michael, E. ,  LIU, Huaqing ,  MCCARTY, Catherine, M. ,  PATEL, Meena, V. ,  ROHDE, Jeffrey, J. ,  COGHLAN, Michael, J. ,  STEWART, Andrew, O.

IPC分类号： C07D237/14 ,  A61K31/50 ,  C07D405/04 ,  C07D409/04

CPC分类号： C07D405/04 ,  C07D237/14 ,  C07D409/04

摘要： The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important 'housekeeping' enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).

公开(公告)号：EP2146973A2

公开(公告)日：2010-01-27

申请号：EP08745908.7

申请日：2008-04-16

申请人： Abbott Laboratories

发明人： CARROLL, William A ,  DART, Michael, J. ,  PEDDI, Sridhar ,  PATEL, Meena, V. ,  NELSON, Derek, W. ,  LI, Tongmei ,  WANG, Xueqing ,  KOLASA, Teodozyj ,  PEREZ-MEDRANO, Arturo

IPC分类号： C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  A61K31/425 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： A61K31/425 ,  A61K31/427 ,  A61K31/429 ,  A61K31/4436 ,  A61K31/4725 ,  A61K31/5377 ,  C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  Y02P20/582

摘要： The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

摘要翻译： 本申请涉及其中R 1，R 2，R 3，R 4和L如说明书中所定义的式（I）的含异噻唑亚基的化合物，包含此类化合物的组合物，以及使用此类化合物和组合物治疗病症和病症的方法。

公开(公告)号：EP1124804B1

公开(公告)日：2005-08-24

申请号：EP99953259.1

申请日：1999-10-27

申请人： ABBOTT LABORATORIES

发明人： BLACK, Lawrence, A. ,  BASHA, Anwer ,  KOLASA, Teodozyj ,  KORT, Michael, E. ,  LIU, Huaqing ,  MCCARTY, Catherine, M. ,  PATEL, Meena, V. ,  ROHDE, Jeffrey, J. ,  COGHLAN, Michael, J. ,  STEWART, Andrew, O.

IPC分类号： C07D237/14 ,  A61K31/50 ,  C07D405/04 ,  C07D409/04

CPC分类号： C07D405/04 ,  C07D237/14 ,  C07D409/04

摘要： The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important 'housekeeping' enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).

公开(公告)号：EP1509213A2

公开(公告)日：2005-03-02

申请号：EP03755402.9

申请日：2003-05-19

申请人： Abbott Laboratories

发明人： BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  HAKEEM, Ahmed, A. ,  KOLASA, Teodozyj ,  MATULENKO, Mark, A. ,  MORTELL, Kathleen, H. ,  PATEL, Meena, V. ,  STEWART, Andrew, O. ,  WANG, Xueqing ,  XIA, Zhiren ,  ZHANG, Henry, Q.

IPC分类号： A61K31/00

CPC分类号： A61K31/00 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/427 ,  A61K31/4418 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506

摘要： The present invention relates to the use of compounds of formula (I), for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

公开(公告)号：EP1483258A1

公开(公告)日：2004-12-08

申请号：EP03716268.2

申请日：2003-03-04

申请人： Abbott Laboratories

发明人： COWART, Marlon, D. ,  BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  STEWART, Andrew, O. ,  PATEL, Meena, V. ,  KOLASA, Teodozyj ,  BRIONI, Jorge, D. ,  ROHDE, Jeffrey ,  ENGSTROM, Kenneth, M.

IPC分类号： C07D401/12 ,  C07D417/12 ,  C07D235/14 ,  C07D401/14 ,  C07D403/12 ,  A61K31/505

CPC分类号： C07D401/12 ,  A61K31/496 ,  C07D403/12

摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

公开(公告)号：EP2274306A1

公开(公告)日：2011-01-19

申请号：EP09719609.1

申请日：2009-03-11

申请人： Abbott Laboratories

发明人： KOLASA, Teodozyi ,  FROST, Jennifer, M. ,  PATEL, Meena, V. ,  LATSHAW, Steven, P. ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing ,  TIETJE, Karin, Rose, Marie ,  PEDDI, Sridhar ,  CARROLL, William, A.

IPC分类号： C07D417/06 ,  A61K31/426

CPC分类号： C07D417/06

摘要： Disclosed herein are compounds of formula (I) wherein R
1 , R
2 , R
3 , R
25a , R
26a , X, and n are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions are also described.

公开(公告)号：EP2222165A1

公开(公告)日：2010-09-01

申请号：EP08852528.2

申请日：2008-11-20

申请人： ABBOTT LABORATORIES

发明人： FLORJANCIC, Alan, S. ,  DART, Michael, J. ,  RYTHER, Keith, B. ,  PEREZ-MEDRANO, Arturo ,  CARROLL, William, A. ,  PATEL, Meena, V. ,  TIETJE, Karin, Rosemarie ,  LI, Tongmei ,  KOLASA, Teodozyj ,  GALLAGHER, Megan, E. ,  PEDDI, Sridhar ,  FROST,Jennifer, M. ,  NELSON, Derek, W.

IPC分类号： A01N43/42

CPC分类号： C07D417/12 ,  C07D277/46 ,  C07D417/06 ,  C07D513/04 ,  C07D513/20

摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, formula (I). wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, formula (II). wherein R1a, R2a, Rx, and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP1373220B1

公开(公告)日：2007-05-30

申请号：EP02731130.7

申请日：2002-03-06

申请人： ABBOTT LABORATORIES

发明人： COWART, Marlon, D. ,  BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  STEWART, Andrew, O. ,  KOLASA, Teodozyj ,  ROHDE, Jeffrey, J. ,  PATEL, Meena, V. ,  BRIONI, Jorge, D.

IPC分类号： C07D235/06 ,  A61P15/10 ,  A61K31/4188

CPC分类号： C07D401/12 ,  C07D235/14 ,  C07D401/14 ,  C07D417/12

摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

公开(公告)号：EP2331516B1

公开(公告)日：2013-03-13

申请号：EP09791365.1

申请日：2009-08-11

申请人： ABBOTT LABORATORIES

发明人： CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LATSHAW, Steven, P. ,  LIU, Bo ,  PATEL, Meena, V. ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing

IPC分类号： C07D261/14 ,  C07D407/06 ,  C07D417/06 ,  C07D285/135 ,  A61K31/433 ,  A61P29/00

CPC分类号： C07D261/14 ,  C07D285/135 ,  C07D407/06 ,  C07D417/06

公开(公告)号：EP2344463A2

公开(公告)日：2011-07-20

申请号：EP09752053.0

申请日：2009-11-04

申请人： Abbott Laboratories

发明人： CARROLL, William, A. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek, W. ,  PATEL, Meena, V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  WANG, Xuequing

IPC分类号： C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  A61K31/425 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  Y02P20/582

摘要： The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R
1 , R
2 , R
3 , R
4 , and L are as defined in the specification, compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.