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    WHITE BLOOD CELL ANALYSIS SYSTEM AND METHOD
    1.
    发明公开
    WHITE BLOOD CELL ANALYSIS SYSTEM AND METHOD 审中-公开
    系统和方法分析血液白细胞

    公开(公告)号：EP2705134A2

    公开(公告)日：2014-03-12

    申请号：EP12779974.0

    申请日：2012-04-26

    申请人： Abbott Laboratories

    发明人： WU, Jiong ,  VACCA, Giacomo

    IPC分类号： C12M1/34 ,  G01N21/64

    CPC分类号： G01N15/1434 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/49 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2015/1488 ,  G01N2021/6439

    摘要： Systems and methods for analyzing blood samples, and more specifically for performing a white blood cell (WBC) differential analysis. The systems and methods screen WBCs by means of fluorescence staining and a fluorescence triggering strategy. As such, interference from unlysed red blood cells (RBCs) and fragments of lysed RBCs is substantially eliminated. The systems and methods also enable development of relatively milder WBC reagent(s), suitable for assays of samples containing fragile WBCs. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye, which corresponds in emission spectrum to an excitation source of a hematology instrument; (b) using a fluorescence trigger to screen the blood sample for WBCs; and (c) using measurements of (1) axial light loss, (2) intermediate angle scatter, (3) 90° polarized side scatter, (4) 90° depolarized side scatter, and (5) fluorescence emission to perform a differentiation analysis.

    BASOPHIL ANALYSIS SYSTEM AND METHOD
    3.
    发明公开
    BASOPHIL ANALYSIS SYSTEM AND METHOD 审中-公开

    公开(公告)号：EP3650831A1

    公开(公告)日：2020-05-13

    申请号：EP19205428.6

    申请日：2012-04-26

    申请人： Abbott Laboratories

    发明人： WU, Jiong ,  BUHL, Michael, R ,  VACCA, Giacomo

    IPC分类号： G01N15/14 ,  G01N33/49 ,  G01N15/00 ,  G01N15/10

    摘要： Provided herein are systems and methods for analyzing blood samples, and more specifically for performing a basophil analysis. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye; and then (b) using measurements of light scatter and fluorescence emission to distinguish basophils from other WBC sub-populations. In one embodiment, the systems and methods include performing a basophil cluster analysis of the blood sample, based on the combination of light scatter and fluorescence measurements.

    METHOD AND APPARATUS FOR RAPIDLY COUNTING AND IDENTIFYING BIOLOGICAL PARTICLES IN A FLOW STREAM
    5.
    发明公开
    METHOD AND APPARATUS FOR RAPIDLY COUNTING AND IDENTIFYING BIOLOGICAL PARTICLES IN A FLOW STREAM 审中-公开
    方法和设备，以便快速计数和流动的流标识生物粒子

    公开(公告)号：EP2215451A1

    公开(公告)日：2010-08-11

    申请号：EP08847427.5

    申请日：2008-11-04

    申请人： Abbott Laboratories

    发明人： VACCA, Giacomo

    IPC分类号： G01N15/14 ,  G01N33/487 ,  G01N33/49 ,  G01N33/50 ,  G01N1/38

    CPC分类号： G01N15/1434 ,  G01N1/38 ,  G01N15/1425 ,  G01N15/1459 ,  G01N2015/0065 ,  G01N2015/1402 ,  G01N2015/1447 ,  G01N2015/1486

    摘要： A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer, by utilizing the technique of laser rastering in combination with a lysis-free single-dilution method. Laser rastering involves sweeping a laser beam across a flowing sample stream in a hematology analyzer. A lysis-free single-dilution method involves performing all the flow cytometer measurements on a sample using a single aliquot, a single lysis-free reagent solution, a single dilution, and a single pass of said dilution through the measurement apparatus. An apparatus suitable for carrying out the method of this invention comprises an optical module comprising a source of light, a scanning device, a lens or system of lenses, a flowcell, detectors, and filters; and an electronic module comprising preamplifiers, analog signal conditioning elements, analog-to-digital converters, field-programmable gate arrays, digital signal processing elements, and data storage elements.

    NUCLEATED RED BLOOD CELL ANALYSIS SYSTEM AND METHOD
    6.
    发明公开
    NUCLEATED RED BLOOD CELL ANALYSIS SYSTEM AND METHOD 审中-公开
    系统维他命ZA分析NUKLEIERTER ERYTHROZYTEN

    公开(公告)号：EP2705136A2

    公开(公告)日：2014-03-12

    申请号：EP12779936.9

    申请日：2012-04-26

    申请人： Abbott Laboratories

    发明人： WU, Jiong ,  COLEMAN, Marilou ,  LIN, Emily H. ,  BUHL, Michael R. ,  VACCA, Giacomo

    IPC分类号： C12M1/42 ,  G01N21/64

    CPC分类号： G01N15/1434 ,  G01N15/1459 ,  G01N15/147 ,  G01N21/6428 ,  G01N33/49 ,  G01N33/80 ,  G01N2015/0069 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1477 ,  G01N2015/1488 ,  G01N2021/6439

    摘要： Systems and methods for analyzing blood samples, and more specifically for performing a nucleated red blood cell (nRBC) analysis. The systems and methods screen a blood sample by means of fluorescence staining and a fluorescence triggering strategy, to identify nuclei-containing particles within the blood sample. As such, interference from unlysed red blood cells (RBCs) and fragments of lysed RBCs is substantially eliminated. The systems and methods also enable development of relatively milder reagent(s), suitable for assays of samples containing fragile white blood cells (WBCs). In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye; (b) using a fluorescence trigger to screen the blood sample for nuclei-containing particles; and (c) using measurements of light scatter and fluorescence emission to distinguish nRBCs from WBCs.

    摘要翻译： 用于分析血液样品的系统和方法，更具体地用于进行有核红细胞（nRBC）分析。 系统和方法通过荧光染色和荧光触发策略筛选血液样品，以鉴定血液样品中含有核的颗粒。 因此，来自未分解的红细胞（RBC）和裂解的RBC的片段的干扰基本上被消除。 这些系统和方法还可以开发适合于含有易碎白细胞（WBC）的样品的测定的较温和的试剂。 在一个实施方案中，系统和方法包括：（a）用专用细胞膜可渗透荧光染料染色血液样品; （b）使用荧光触发器筛选含有核的颗粒的血液样品; 和（c）使用光散射和荧光发射的测量来区分来自WBC的nRBC。

    BASOPHIL ANALYSIS SYSTEM AND METHOD
    10.
    发明公开
    BASOPHIL ANALYSIS SYSTEM AND METHOD 有权
    系统在维也纳ZUR分析BASOPHILER STOFFE

    公开(公告)号：EP2705135A2

    公开(公告)日：2014-03-12

    申请号：EP12779290.1

    申请日：2012-04-26

    申请人： Abbott Laboratories

    发明人： WU, Jiong ,  BUHL, Michael, R. ,  VACCA, Giacomo

    IPC分类号： C12M1/42 ,  G01N21/64

    摘要： Provided herein are systems and methods for analyzing blood samples, and more specifically for performing a basophil analysis. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye; and then (b) using measurements of light scatter and fluorescence emission to distinguish basophils from other WBC sub-populations. In one embodiment, the systems and methods include performing a basophil cluster analysis of the blood sample, based on the combination of light scatter and fluorescence measurements.

    摘要翻译： 本文提供了用于分析血液样品的系统和方法，并且更具体地用于进行嗜碱性粒细胞分析。 在一个实施方案中，系统和方法包括：（a）用专用细胞膜可渗透荧光染料染色血液样品; 然后（b）使用光散射和荧光发射的测量来区分嗜碱性粒细胞与其他WBC亚种群。 在一个实施方案中，系统和方法包括基于光散射和荧光测量的组合来进行血液样品的嗜碱性粒细胞聚类分析。