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公开(公告)号：EP4403218A2
公开(公告)日：2024-07-24
申请号：EP24170761.1
申请日：2018-12-14
申请人： ABL Bio, Inc.
发明人： AHN, Jinhyung , AN, Sungwon , KIM, Dongin , SUNG, Eunsil , EOM, Jaehyun , LEE, Sang Hoon , YOU, Weonkyoo , KIM, Juhee , PARK, Kyungjin , CHUNG, Hyejin , JUNG, Jinwon , LEE, Bora , SUNG, Byungje , KIM, Yeunju , SON, Yong-Gyu , AHN, Seawon , SONG, Daehae , YOO, Jiseon , PAK, Youngdon , YEOM, Donghoon , LEE, Yoseob , JUNG, Jaeho
IPC分类号： A61P25/00
CPC分类号： C07K16/2863 , C07K16/18 , C07K2317/3120130101 , C07K2317/9420130101 , C07K2317/9220130101 , C07K2317/7720130101 , A61P25/16 , C07K2317/2120130101 , C07K2317/2420130101 , C07K2317/3420130101 , C07K2317/3520130101 , C07K2317/52620130101 , C07K2317/56520130101 , C07K2317/62220130101 , C07K2317/3320130101 , A61K2039/50520130101 , A61P25/00
摘要： The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and use of the bi-specific antibody for treating or diagnosing synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates. The IGF1R portion of the bi-specific antibody acts as a shuttle to penetrate the blood brain barrier, allowing the alpha-synuclein portion to exert its action in the brain. Further, the half-life of the bi-specific antibody may be extended to maintain efficacy over time.
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公开(公告)号：EP4340881A1
公开(公告)日：2024-03-27
申请号：EP22806958.9
申请日：2022-05-12
申请人： ABL Bio Inc.
发明人： PARK, Kyungjin , SONG, Daehae , JUNG, Jinwon , SUNG, Byungje , YUN, Hyesu , SHIN, Jung-Won , AN, Sungwon , KIM, Juhee , LEE, Bora , AHN, Jinhyung , KIM, Dongin , KIM, Donghwan , SON, Yong-Gyu , PAK, Youngdon
IPC分类号： A61K39/395 , A61P25/28 , C07K16/18
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公开(公告)号：EP4048699A1
公开(公告)日：2022-08-31
申请号：EP20889266.1
申请日：2020-11-23
申请人： ABL Bio Inc. , I-MAB
发明人： SUNG, Eunsil , PARK, Eunyoung , JEON, Jaehyoung , JEONG, Junhyun , SONG, Daehae , LEE, Sunju , FANG, Lei , JIANG, Wenqing , CUI, Feifei
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公开(公告)号：EP4025257A1
公开(公告)日：2022-07-13
申请号：EP20861806.6
申请日：2020-07-27
发明人： PARK, Yun Hee , SONG, Ho Young , RYU, Hyun Min , KIM, Sung Min , BAEK, Ju Yuel , OH, Ji Hye , HAN, Nara , KIM, Hyoung Rae , PARK, Kyung Eun , LEE, Hyeun Joung , LEE, Ju Young , KANG, Dae Hyuck , YANG, Young-Jae , YOU, Ji-Na , KIM, Yong Zu , LEE, Chang Sun , CHAE, Jeiwook , JUNG, Jinwon , KIM. Juhee , LEE, Bora , SONG, Daehae , SUNG, Byungje , YEOM, Donghoon , EOM, Jaehyun , HONG, Youngeun , AHN, Jinhyung , LEE, Yangsoon , PARK, Kyungjin , YOO, Jiseon , PARK, Minji
IPC分类号： A61K47/68 , A61K31/5517 , A61P35/00 , C07K16/28
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公开(公告)号：EP3985022A1
公开(公告)日：2022-04-20
申请号：EP20822425.3
申请日：2020-06-15
申请人： ABL Bio, Inc.
发明人： AN, Sungwon , AHN, Jinhyung , SUNG, Byungje , KIM, Dongin , SONG, Daehae , EOM, Jaehyun , SON, Yong-Gyu , PARK, Kyungjin , KIM, Juhee , JUNG, Jinwon , LEE, Bora , YUN, Hyesu
摘要： The present disclosure relates to a bispecific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bispecific antibody for the prevention, treatment and / or diagnosis of synucleinopatheis associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.
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公开(公告)号：EP3936151A1
公开(公告)日：2022-01-12
申请号：EP20765892.3
申请日：2020-03-06
申请人： ABL Bio, Inc.
发明人： JUNG, Jinwon , KIM, Juhee , PAK, Youngdon , SONG, Daehae , YEOM, Donghoon , EOM, Jaehyun , HONG, Youngeun , LEE, Bora
摘要： The present invention relates to a novel compound comprising a galactose trigger moiety and cyclopropabenzindole (CBI), and an antibody-drug conjugate prepared by using same.
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7.发明公开
公开(公告)号：EP4141025A1
公开(公告)日：2023-03-01
申请号：EP20908197.5
申请日：2020-12-24
申请人： ABL Bio, Inc.
发明人： SONG, Daehae , PAK, Youngdon , JUNG, Jinwon , HONG, Junghyeon , LIM, Heejin , KIM, Dongin
摘要： Provided is a method of purifying a mixture of Fc-containing bioactive peptides by using an affinity column including an affinity matrix containing a protein A ligand, wherein the mixture of Fc-containing bioactive peptides includes a first Fc-containing bioactive peptide and a second Fc-containing bioactive peptide, and the second Fc-containing bioactive peptide includes at least one more human VH3 domain, compared to the first Fc-containing bioactive peptide. According to the purification method, bioactive peptides having the same or similar structures can be precisely separated to the high level of purity while simplification of the process is achieved.
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公开(公告)号：EP3802612A1
公开(公告)日：2021-04-14
申请号：EP19807093.0
申请日：2019-05-24
申请人： ABL Bio Inc.
发明人： PARK, Kyeongsu , LEE, Yangsoon , CHUNG, Hyejin , JUNG, Uijung , SON, Yong-Gyu , HA, Sang-Jun , KIM, Myeong Joon , PARK, Eunyoung , PARK, Kyungjin , SUNG, Eunsil , KIM, Yeunju , AHN, Jinhyung , SUNG, Byungje , SONG, Daehae , PAK, Youngdon
IPC分类号： C07K16/28 , A61K47/68 , A61P35/00 , G01N33/574 , A61K39/00
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公开(公告)号：EP3725806A1
公开(公告)日：2020-10-21
申请号：EP18889608.8
申请日：2018-12-14
申请人： ABL Bio Inc.
发明人： AHN, Jinhyung , AN, Sungwon , KIM, Dongin , SUNG, Eunsil , EOM, Jaehyun , LEE, Sang Hoon , YOU, Weonkyoo , KIM, Juhee , PARK, Kyungjin , CHUNG, Hyejin , JUNG, Jinwon , LEE, Bora , SUNG, Byungje , KIM, Yeunju , SON, Yong-gyu , AHN, Seawon , SONG, Daehae , YOO, Jiseon , PAK, Youngdon , YEOM, Donghoon , LEE, Yoseob , JUNG, Jaeho
摘要： The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bi-specific antibody for the prevention, treatment and / or diagnosis of synucleinopatheis associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.
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公开(公告)号：EP3725802A2
公开(公告)日：2020-10-21
申请号：EP18879299.8
申请日：2018-11-16
申请人： ABL Bio Inc.
发明人： LEE, Sang Hoon , YOU, Weonkyoo , AHN, Jinhyung , AN, Sungwon , JUNG, Jinwon , LEE, Bora , KIM, Dongin , SUNG, Byungje , SON, Yonggyu , KIM, Yeunju , EOM, Jaehyun , AHN, Seawon , PAK, Youngdon , YEOM, Donghoon , SONG, Daehae
摘要： The present invention relates to an anti-alpha-synuclein antibody preferentially recognizing alpha-synuclein aggregates and a use of detection, diagnosis, and/or treatment or prevention of various diseases caused by accumulation of alpha-synuclein aggregates, or their related symptom diseases by using the anti-alpha-synuclein antibody.
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