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公开(公告)号：EP1752768A4
公开(公告)日：2007-11-28
申请号：EP05741615
申请日：2005-05-19
发明人： OHUE CHIHARU , MAKI NOBORU , KIMURA TATSUJI
IPC分类号： G01N33/576 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/569
CPC分类号： G01N33/5761
摘要： It is intended to provide a method of detecting or quantifying a hepatitis B virus (HBV) antigen in the serum and a method of very conveniently and efficiently treating a specimen to be used in the detection and quantification as described above. A method of treating a specimen containing hepatitis B virus (HBV) characterized by treating the HBV-containing specimen with a treating agent containing (1) an acidifying agent and (2) a protein denaturation agent, an amphoteric surfactant having an alkyl group and a tertiary amine or a quaternary ammonium salt in its molecule or a cationic surfactant to thereby liberate an HBV antigen and destroy an antibody bonded to the HBV antigen.
摘要翻译： 目的在于提供一种检测或定量血清中乙型肝炎病毒（HBV）抗原的方法，以及非常方便和有效地处理如上所述用于检测和定量的样本的方法。 一种治疗含有乙型肝炎病毒（HBV）的标本的方法，其特征在于用含有（1）酸化剂和（2）蛋白质变性剂，两性表面活性剂的处理剂处理含有HBV的标本，所述两性表面活性剂具有烷基和 叔胺或其分子中的季铵盐或阳离子表面活性剂，从而释放HBV抗原并破坏与HBV抗原结合的抗体。
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公开(公告)号：EP2151495A4
公开(公告)日：2010-06-02
申请号：EP08752225
申请日：2008-04-28
发明人： MORI KENICHI , MAKI NOBORU , FUKAI HIROMI , OHUE CHIHARU
CPC分类号： G01N33/5008 , C07K14/005 , C12N15/86 , C12N2770/24222 , C12N2770/24243 , C12Q1/707 , G01N33/5767 , G01N2333/186 , G01N2500/00
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公开(公告)号：EP1783218A4
公开(公告)日：2009-02-18
申请号：EP05755873
申请日：2005-06-24
发明人： YAGI SHINTARO , YAMAGUCHI KENJIRO , ORI KENICHI , TANAKA EIJI , KIYOSAWA KENDO , MAKI NOBORU
CPC分类号： C07K14/005 , C07K16/109 , C12N15/70 , C12N2770/24222
摘要： A truncated form of hepatitis C virus gene obtained by deleting a portion of a region of a gene encoding NS2 protein from the core protein of hepatitis C virus while sustaining its translation frame. In particular, a gene as described above wherein the above-described portion of a region of the gene is located in a region encoding E1 protein and E2 protein.
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公开(公告)号：EP2322609A4
公开(公告)日：2013-01-30
申请号：EP09797935
申请日：2009-07-15
发明人： MAKI NOBORU , MORI KENICHI , FUKAI HIROMI
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/24221 , C12N2770/24222 , C12N2770/24243
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公开(公告)号：EP1783211A4
公开(公告)日：2007-08-08
申请号：EP04746550
申请日：2004-06-22
发明人： MAKI NOBORU , KIMURA TATSUJI , MATSUMOTO AKIHIRO , ROKUHARA AKINORI , TANAKA EIJI , KIYOSAWA KENDO
IPC分类号： C12N7/00 , C12Q1/70 , G01N33/53 , G01N33/576
CPC分类号： G01N33/5761 , C12N7/00 , C12N2730/10111 , C12N2730/10143 , C12Q1/706
摘要： Hepatitis B virus (HBV) particles in a bodily fluid sample containing HBV-RNA but no HBV-DNA; a method of measuring the particles as claimed in claim 1 by measuring HBV-RNA; a method of evaluating the therapeutic effect on HBV infection of a drug having an RNA-dependent DNA polymerase inhibitory effect characterized in that the above measurement is carried out on a bodily fluid of a patient under the corresponding therapy; and a method of presuming the risk of liver caner onset or selecting a risk group of liver cancer onset.
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公开(公告)号：EP2626426A4
公开(公告)日：2014-04-02
申请号：EP11830767
申请日：2011-10-07
发明人： MORI KENICHI , MAKI NOBORU , FUKAI HIROMI
CPC分类号： C07H21/02 , C07K14/005 , C12N2770/24222
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公开(公告)号：EP1806363A4
公开(公告)日：2007-12-12
申请号：EP05785966
申请日：2005-09-21
发明人： MAKI NOBORU , FUKUDA YASUYUKI , KIMURA TATSUJI , ODA YOKO , OHUE CHIHARU , KUSANO OSAMU
IPC分类号： C07K16/08 , C07K14/02 , C12N15/02 , C12P21/08 , G01N33/531 , G01N33/569 , G01N33/576
CPC分类号： G01N33/5761 , C07K14/005 , C07K16/082 , C12N2730/10122
摘要： [PROBLEMS] To provide a probe useful in the detection of HBV or HBs antigen by which an escape mutant of hepatitis B virus (HBV) possibly occurring in a specimen can be detected; and a method of using the same. [MEANS FOR SOLVING PROBLEMS] A probe capable of recognizing an epitope located on a peptide comprising the amino acid sequence of SEQ ID NO:1; and a method of detecting hepatitis B virus or hepatitis B virus s antigen by using this probe.
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公开(公告)号：EP1535927A4
公开(公告)日：2006-06-21
申请号：EP03794268
申请日：2003-09-05
发明人： MAKI NOBORU , KIMURA TATSUJI , YAGI SHINTARO
CPC分类号： C07K14/005 , A61K2039/5258 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , G01N33/5761
摘要： It is intended to provide an HBV precore protein capable of forming particles and a means of assaying the same. A novel HBV precore protein forming HBV virus-like particles is identified. Thus, this novel HBV precore protein is provided. It is also intended to provide core-like particles and virus-like particles formed by this HBV precore protein. These virus-like particles are usable in vaccines and remedies. Moreover, it is intended to provide a method of assaying the HBV precore protein and a method of assaying an anti-HBV precore protein antibody.
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