公开(公告)号：EP2122327A4

公开(公告)日：2010-06-16

申请号：EP08743832

申请日：2008-03-13

申请人： ADVANCED LIQUID LOGIC INC

发明人： SRINIVASAN VIJAY ,  PAMULA VAMSEE K ,  POLLACK MICHAEL G ,  WANG TIH-HONG

IPC分类号： G01N21/00 ,  G01N21/03

CPC分类号： G01N21/0303 ,  G01N21/031 ,  G01N2021/035 ,  G01N2021/036 ,  G01N2201/08

公开(公告)号：EP2553473A4

公开(公告)日：2016-08-10

申请号：EP11766501

申请日：2011-03-30

申请人： ADVANCED LIQUID LOGIC INC

发明人： BAUER WILLIAM CRAIG ,  POORE MATTHEW ,  WANG TIH-HONG

IPC分类号： B01F13/00 ,  B01L3/00 ,  B01L7/00

CPC分类号： G01N27/44734 ,  B01F13/0071 ,  B01F13/0076 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L7/525 ,  B01L7/54 ,  B01L2200/027 ,  B01L2200/06 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/18 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/0427 ,  B01L2400/043 ,  B01L2400/0677 ,  B01L2400/0683 ,  G01N27/44791

摘要： The invention relates to a droplet actuator device and methods for integrated sample preparation and analysis of a biological sample. A droplet actuator device is provided for conducting droplet operations. The droplet actuator device may include a bottom substrate and a top substrate separated from each other to form a gap therebetween; an arrangement of droplet operations electrodes arranged on one or both of the bottom and/or top substrates for conducting droplet operations thereon; a reagent storage layer comprising one or more compartments bound to the top substrate; and one or more openings arranged to provide a fluidic path from the one or more compartments into the gap, upon breach of a breachable seal separating the one or more compartments and openings.

公开(公告)号：EP2588322A4

公开(公告)日：2013-12-25

申请号：EP11810072

申请日：2011-06-24

申请人： ADVANCED LIQUID LOGIC INC

发明人： WANG TIH-HONG ,  BRACKETT GEORGE ,  CLEVENGER DAVID ,  BORT DONOVAN

IPC分类号： B41J2/175 ,  B41F31/08

CPC分类号： B01L3/0241 ,  B01L3/502784 ,  B41J2/14024

摘要： The invention provides droplet actuator assemblies and systems and methods of manufacturing the droplet actuator assemblies. In certain embodiments, two-piece enclosures are used to form a droplet actuator assembly that houses a droplet operations substrate. In certain other embodiments, one-piece enclosures are used to form a droplet actuator assembly that houses a droplet operations substrate. In the plastic injection molding process for forming substrates of the droplet actuator assemblies of the present invention may utilize insert molding (or overmolding) processes for forming a gasket in at least one substrate, thereby avoiding the need for providing and installing a separate gasket component. Further, the droplet actuator assemblies may include features that allow ultrasonic welding processes to be used for bonding substrates together. The manufacturing systems of the present invention for fabricating the droplet actuator assemblies may utilize continuous flow reel-to-reel manufacturing processes.

摘要翻译： 本发明提供了液滴致动器组件以及制造液滴致动器组件的系统和方法。 在某些实施例中，两件式外壳用于形成容纳液滴操作基板的液滴致动器组件。 在某些其他实施例中，使用单件式外壳来形成容纳液滴操作基板的液滴致动器组件。 在用于形成本发明的液滴致动器组件的基底的塑料注射成型工艺中，可以利用用于在至少一个基底中形成垫圈的嵌入成型（或包覆成型）工艺，从而避免提供和安装单独的垫圈部件的需要。 此外，液滴致动器组件可以包括允许使用超声波焊接工艺将基板粘合在一起的特征。 用于制造液滴致动器组件的本发明的制造系统可以利用连续流量的卷对卷制造工艺。