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公开(公告)号：EP2424857A1
公开(公告)日：2012-03-07
申请号：EP10770475.1
申请日：2010-05-01
发明人： DELONG, Mitchell, A. , STURDIVANT, Jill, Marie , ROYALTY, Susan, M. , HEINTZELMAN, Geoffrey, Richard , YINGLING, Jeffrey, D. , KOPCZYNSKI, Casey
IPC分类号： C07D401/04 , A61P9/00 , C12N15/09
CPC分类号： C07D417/12 , C07C237/20 , C07C237/42 , C07C2601/08 , C07C2601/14 , C07D217/00 , C07D217/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
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2.发明授权BETA-AND GAMMA-AMINO-ISOQUINOLINE AMIDE COMPOUNDS AND SUBSTITUTED BENZAMIDE COMPOUNDS 有权β-和γ-氨基 - 异喹啉酰胺化合物和取代的苯甲酰胺化合物
公开(公告)号：EP2326623B1
公开(公告)日：2014-04-16
申请号：EP09790775.2
申请日：2009-07-23
IPC分类号： C07D217/02 , C07D217/24 , C07D333/24 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/472 , A61P27/06
CPC分类号： C07D333/24 , A61K31/16 , A61K31/381 , A61K31/47 , A61K31/4709 , C07C237/04 , C07C237/48 , C07D213/56 , C07D217/02 , C07D217/24 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. The invention further provides compositions containing the beta or gamma-amino isoquinoline amide compounds or substituted benzamide compounds.
摘要翻译： 公开了β和γ-氨基异喹啉酰胺化合物和取代的苯甲酰胺化合物。 特别地，本发明提供影响细胞中激酶功能并且可用作治疗剂或与治疗剂有关的化合物。 本发明的化合物可用于治疗各种疾病和病症，包括诸如青光眼，心血管疾病和异常生长特征的疾病如眼癌等眼疾。 本发明还提供含有β或γ-氨基异喹啉酰胺化合物或取代的苯甲酰胺化合物的组合物。
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3.发明公开BETA-AND GAMMA-AMINO-ISOQUINOLINE AMIDE COMPOUNDS AND SUBSTITUTED BENZAMIDE COMPOUNDS 有权β-和γ-氨基 - 异喹啉酰胺化合物和取代的苯甲酰胺化合物
公开(公告)号：EP2326623A2
公开(公告)日：2011-06-01
申请号：EP09790775.2
申请日：2009-07-23
IPC分类号： C07D217/02 , C07D217/24 , C07D333/24 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/472 , A61P27/06
CPC分类号： C07D333/24 , A61K31/16 , A61K31/381 , A61K31/47 , A61K31/4709 , C07C237/04 , C07C237/48 , C07D213/56 , C07D217/02 , C07D217/24 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. The invention further provides compositions containing the beta or gamma-amino isoquinoline amide compounds or substituted benzamide compounds.
摘要翻译： 公开了β和γ-氨基异喹啉酰胺化合物和取代的苯甲酰胺化合物。 特别地，本发明提供了影响细胞中激酶功能并且可用作治疗剂或与治疗剂一起使用的化合物。 本发明的化合物可用于治疗多种疾病和病症，包括眼病如青光眼，心血管疾病和以异常生长为特征的疾病如癌症。 本发明进一步提供了含有β或γ-氨基异喹啉酰胺化合物或取代的苯甲酰胺化合物的组合物。
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4.发明公开6-AND 7-AMINO ISOQUINOLINE COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME 有权6-和7-氨基异喹啉化合物及其制备和使用方法
公开(公告)号：EP2252589A2
公开(公告)日：2010-11-24
申请号：EP09702189.3
申请日：2009-01-15
发明人： DELONG, Mitchell, A. , STURDIVANT, Jill, Marie , HEINTZELMAN, Geoffrey, Richard , ROYALTY, Susan, M.
IPC分类号： C07D217/02 , C07D409/12 , A61K31/4709 , A61P35/00 , A61P25/00 , A61P9/00
CPC分类号： C07D217/02 , C07D409/12
摘要： 6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6- and 7-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
摘要翻译： 提供了影响，抑制或减少激酶作用的6-和7-氨基异喹啉化合物。 还提供了包含治疗有效量的6-和7-氨基异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物来影响疾病状态或病症例如癌症，肥胖症和青光眼的各种方法。
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公开(公告)号：EP2118064A2
公开(公告)日：2009-11-18
申请号：EP08713603.2
申请日：2008-01-07
发明人： DELONG, Mitchell, A. , ROYALTY, Susan, M. , STURDIVANT, Jill, Marie , HEINTZELMAN, Geoffrey, Richard
IPC分类号： C07D217/14 , A61K31/47
CPC分类号： C07D217/02 , C07D215/38 , C07D217/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
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公开(公告)号：EP3500251A1
公开(公告)日：2019-06-26
申请号：EP17841778.8
申请日：2017-03-31
IPC分类号： A61K31/16 , C07D333/22 , C07C237/48
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公开(公告)号：EP2118064B1
公开(公告)日：2014-11-12
申请号：EP08713603.2
申请日：2008-01-07
发明人： DELONG, Mitchell, A. , ROYALTY, Susan, M. , STURDIVANT, Jill, Marie , HEINTZELMAN, Geoffrey, Richard
IPC分类号： C07D217/14 , A61K31/47
CPC分类号： C07D217/02 , C07D215/38 , C07D217/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
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8.发明授权DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE 有权HEMMER MIT DOPPELMECHANISMUS ZUR BEHANDLUNG VON ERKRANKUNGEN
公开(公告)号：EP2424842B1
公开(公告)日：2015-10-28
申请号：EP10709100.1
申请日：2010-01-27
IPC分类号： C07D217/00 , C07D401/12 , C07D409/12 , C07D417/12 , C07C237/00 , A61P27/00 , A61K31/33
CPC分类号： C07D417/12 , C07C237/20 , C07C237/42 , C07C2601/08 , C07C2601/14 , C07D217/00 , C07D217/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
摘要翻译： 提供作为rho激酶和单胺转运蛋白（MAT）的抑制剂的化合物，其用于改善疾病状态或状况。 还提供了包含这些化合物的组合物。 还提供了治疗疾病或病症的方法，所述方法包括施用本发明的化合物。 一种这样的疾病可以是青光眼，除其他有益效果之外，可以实现眼压显着降低（IOP）。
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9.发明授权6-AND 7-AMINO ISOQUINOLINE COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME 有权6-和7-氨基异喹啉化合物及其制备和使用方法
公开(公告)号：EP2252589B1
公开(公告)日：2012-11-21
申请号：EP09702189.3
申请日：2009-01-15
发明人： DELONG, Mitchell, A. , STURDIVANT, Jill, Marie , HEINTZELMAN, Geoffrey, Richard , ROYALTY, Susan, M.
IPC分类号： C07D217/02 , C07D409/12 , A61K31/4709 , A61P35/00 , A61P25/00 , A61P9/00
CPC分类号： C07D217/02 , C07D409/12
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公开(公告)号：EP2424842A2
公开(公告)日：2012-03-07
申请号：EP10709100.1
申请日：2010-01-27
IPC分类号： C07D217/00 , C07D401/12 , C07D409/12 , C07D417/12 , C07C237/00 , A61P27/00 , A61K31/33
CPC分类号： C07D417/12 , C07C237/20 , C07C237/42 , C07C2601/08 , C07C2601/14 , C07D217/00 , C07D217/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
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