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公开(公告)号：EP2967066A4
公开(公告)日：2016-11-02
申请号：EP14762974
申请日：2014-03-14
发明人： PETERS KEVIN , SHALWITZ ROBERT , JANUSZ JOHN , SMITH ALEXANDER
IPC分类号： A01N43/78 , A61K31/425 , C07C309/00
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/538 , A61K38/179 , A61K39/3955 , C07D277/30 , C07D277/56 , C07D277/60 , C07D277/64 , C07D417/04
摘要： Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.
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2.发明公开METHODS FOR TREATING VASCULAR LEAK SYNDROME AND CANCER 审中-公开VERFAHREN ZUR BEHANDLUNG VON KAPILLARLECKSYNDROM UND KREBS
公开(公告)号：EP2766043A4
公开(公告)日：2015-06-10
申请号：EP12840220
申请日：2012-10-15
发明人： PETERS KEVIN , SHALWITZ ROBERT
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/40
摘要： Disclosed are methods for treating Vascular Leak Syndrome and preventing cancer metastasis. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, sepsis, cancer or the presence of pathogens.
摘要翻译： 公开了治疗血管性渗漏综合征和预防癌症转移的方法。 进一步公开的是用于治疗由于炎性疾病，败血症，癌症或病原体的存在引起的血管渗漏的方法。
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3.发明公开
公开(公告)号：EP2385763A4
公开(公告)日：2013-03-06
申请号：EP10729682
申请日：2010-01-12
发明人： SHALWITZ ROBERT , PETERS KEVIN GENE
IPC分类号： A01N43/82 , A61K31/41 , A61K31/426 , A61K31/427 , A61K45/06
CPC分类号： C07D277/28 , A61K31/41 , A61K31/4245 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/538 , A61K45/06 , C07D277/34 , C07D277/60 , C07D277/64 , C07D417/04 , C07D417/06 , C07D417/12 , A61K2300/00
摘要： Disclosed are methods for treating Vascular Leak Syndrome. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, inter alia, sepsis, lupus, irritable bowel disease. Yet further disclosed are methods for treating renal cell carcinoma and melanoma. Still further disclosed are methods for reducing metastasis of malignant cells and/or preventing the proliferation of carcinoma cells via spreading due to vascular leakage.
摘要翻译： 公开了治疗血管性渗漏综合征的方法。 进一步公开的是用于治疗由于炎性疾病，特别是败血症，狼疮，肠易激惹病引起的血管渗漏的方法。 还公开了治疗肾细胞癌和黑素瘤的方法。 还进一步公开的是减少恶性细胞的转移和/或由于血管渗漏而扩散癌细胞增殖的方法。
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4.发明公开COMPOSITIONS AND METHODS FOR TREATING OCULAR EDEMA, NEOVASCULARIZATION AND RELATED DISEASES 有权组合物以及用于治疗眼睛浮肿，新生血管形成方法，及相关疾病
公开(公告)号：EP2624916A4
公开(公告)日：2014-03-19
申请号：EP11831498
申请日：2011-10-05
发明人： PETERS KEVIN G , SHALWITZ ROBERT
IPC分类号： A61K31/426 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/513 , A61P27/02
CPC分类号： C07D417/04 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K31/506 , C07D277/28
摘要： Disclosed are methods for the treatment of diseases or conditions of the eye, especially retinopathies, ocular edema and ocular neovascularization. Non-limiting examples of these diseases or conditions include diabetic macular edema, age-related macular degeneration (wet form), choroidal neovascularization, diabetic retinopathy, retinal vein occlusion (central or branch), ocular trauma, surgery induced edema, surgery induced neovascularization, cystoid macular edema, ocular ischemia, uveitis, and the like.
摘要翻译： 本发明公开了用于治疗疾病或眼睛的条件下，特别是爱视网膜病，眼部水肿和眼部新生血管形成的治疗方法。 非限制性的合成疾病或病症包括糖尿病性黄斑水肿，与年龄相关的黄斑变性（湿型），脉络膜新生血管形成，糖尿病视网膜病变，视网膜静脉阻塞（中央或分支），眼创伤，手术诱导的水肿，手术诱导的新生血管形成的例子， 黄斑囊样水肿，眼缺血，葡萄膜炎，等等。
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公开(公告)号：EP2496084A4
公开(公告)日：2012-11-21
申请号：EP10829180
申请日：2010-11-05
发明人： GARDNER JOSEPH H , SHALWITZ ROBERT
IPC分类号： A61K31/497
CPC分类号： C07D211/96 , A61K31/44 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D211/86 , C07D213/02 , C07D213/69 , C07D401/06 , C07D401/14 , C07D417/06 , C07D491/113
摘要： Disclosed herein are prolyl hydroxylase inhibitors that can stabilize hypoxia inducible factor-1 alpha (HIF-1±), as well as hypoxia inducible factor-2 (HIF-2). Also disclosed herein are pharmaceutical compositions comprising one or more of the disclosed compounds. Yet further disclosed are methods for stimulating the cellular immune response in a mammal such as increasing phagocytosis, for example, prolonging the life of phagocytes, inter alia, kerotyiocytes, neutrophils. As such the disclosed compounds provide methods for treating diseases that relate to the body's immune response.
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公开(公告)号：EP2766044A4
公开(公告)日：2015-06-10
申请号：EP12840725
申请日：2012-10-15
发明人： PETERS KEVIN , SHALWITZ ROBERT
IPC分类号： A61K39/395
CPC分类号： C07K16/40 , A61K2039/505 , A61K2039/54 , C07K2317/75 , C07K2317/76
摘要： Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular edema, choroidal neovascularization, diabetic retinopathy, trauma, ocular ischemia, retinal angiomatous proliferation, macular telangiectasia and uveitis.
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7.发明公开COMPOUNDS, COMPOSITIONS, AND METHODS FOR PREVENTING METASTASIS OF CANCER CELLS 审中-公开化合物，组合物和方法，以防止癌症转移
公开(公告)号：EP2451279A4
公开(公告)日：2013-03-27
申请号：EP10797461
申请日：2010-01-12
发明人： SHALWITZ ROBERT , PETERS KEVIN GENE
CPC分类号： A61K31/426 , A61K31/337 , A61K31/41 , A61K31/4155 , A61K31/4192 , A61K31/425 , A61K31/427 , A61K31/428 , A61K31/4375 , A61K31/4439 , A61K31/497 , A61K31/517 , A61K31/538 , A61K31/65 , A61K31/7068 , A61K38/2013 , A61K39/39558 , A61K45/06 , C07D277/28 , C07D277/64 , C07D417/04 , C07D417/12 , C07D417/14 , A61K2300/00
摘要： Disclosed are methods for preventing metastasis of cancer cells. The disclosed compounds can be used to prevent the spread of tumor or other types of cancer cells.
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8.发明公开
公开(公告)号：EP2496082A4
公开(公告)日：2012-11-21
申请号：EP10829174
申请日：2010-11-05
发明人： SHALWITZ ROBERT , GARDNER JOSEPH H
IPC分类号： A61K31/497
CPC分类号： C07D211/96 , A61K31/44 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D211/86 , C07D213/02 , C07D213/69 , C07D401/06 , C07D401/14 , C07D417/06 , C07D491/113
摘要： Disclosed herein are prolyl hydroxylase inhibitors that can stabilize hypoxia inducible factor-1 alpha (HIF-1±), as well as hypoxia inducible factor-2 (HIF-2). Also disclosed herein are pharmaceutical compositions comprising one or more of the disclosed compounds. Yet further disclosed are methods for stimulating the cellular immune response in a mammal such as increasing phagocytosis, for example, prolonging the life of phagocytes, inter alia, kerotyiocytes, neutrophils. As such the disclosed compounds provide methods for treating diseases that relate to the body's immune response.
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公开(公告)号：EP2496236A4
公开(公告)日：2012-09-12
申请号：EP10829176
申请日：2010-11-05
发明人： GARDNER JOSEPH H , SHALWITZ ROBERT
IPC分类号： A61K31/497
CPC分类号： C07D211/96 , A61K31/44 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D211/86 , C07D213/02 , C07D213/69 , C07D401/06 , C07D401/14 , C07D417/06 , C07D491/113
摘要： Disclosed herein are prolyl hydroxylase inhibitors that can stabilize hypoxia inducible factor-1 alpha (HIF-1±), as well as hypoxia inducible factor-2 (HIF-2). Also disclosed herein are pharmaceutical compositions comprising one or more of the disclosed compounds. Yet further disclosed are methods for stimulating the cellular immune response in a mammal such as increasing phagocytosis, for example, prolonging the life of phagocytes, inter alia, kerotyiocytes, neutrophils. As such the disclosed compounds provide methods for treating diseases that relate to the body's immune response.
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