公开(公告)号：EP3066455A4

公开(公告)日：2017-07-05

申请号：EP14858305

申请日：2014-11-04

申请人： AGENCY SCIENCE TECH & RES

发明人： WONG CHI LOK ,  OLIVO MALINI

IPC分类号： G01N21/552 ,  G01N21/21

CPC分类号： G01N21/553 ,  G01N21/21 ,  G01N2201/0683 ,  G01N2201/12

摘要： An optical sensing device is provided, including a first polarizer, a second polarizer, wherein the first polarizer and the second polarizer have respective transmission axes aligned in orthogonal directions, an SPR sensor arrangement including an SPR sensing surface, the SPR sensor arrangement arranged to receive an incident light beam passed through a polarizer to be reflected at the SPR sensing surface and transmitted through a second polarizer to provide a transmitted light beam, a detector arrangement configured to detect the transmitted light beam, the transmitted light beam including a sensing signal and a reference signal, and a processor electrically coupled to the detector arrangement, the processor configured to perform a subtraction operation between the sensing signal and the reference signal. The optical sensing is based on a differential measurement scheme. The subtraction between the sensing signal and the reference signal cancels the common path noise and enhances the sensor resolution.

摘要翻译： 提供了一种光学感测设备，其包括第一偏振器，第二偏振器，其中第一偏振器和第二偏振器具有在正交方向上对准的相应透射轴，包括SPR感测表面的SPR传感器布置，SPR传感器布置被布置为接收 入射光束穿过偏振器以在SPR感测表面处反射并透射通过第二偏振器以提供透射光束;检测器装置，配置为检测透射光束;透射光束包括感测信号;和 参考信号以及电耦合到所述检测器装置的处理器，所述处理器被配置为执行所述感测信号和所述参考信号之间的减法操作。 光学传感基于差分测量方案。 感测信号和参考信号之间的相减抵消了公共路径噪声并提高了传感器分辨率。

公开(公告)号：EP2855360A4

公开(公告)日：2016-01-20

申请号：EP13797062

申请日：2013-05-28

申请人： AGENCY SCIENCE TECH & RES ,  UNIV NANYANG TECH

发明人： KONG KIEN VOON ,  OLIVO MALINI ,  LEONG WENG KEE ,  LAM ZHIYONG

IPC分类号： C01G55/00 ,  B82Y15/00 ,  C07F17/00 ,  G01N21/65 ,  G01N33/532 ,  G01N33/543

CPC分类号： G01N21/658 ,  B82Y15/00 ,  G01N33/532 ,  G01N33/54346 ,  G01N33/54373 ,  G01N33/57492

摘要： A surface enhanced Raman spectroscopy (SERS) marker conjugate is provided. The SERS marker conjugate comprises a metallic nanoparticle and an organometallic material attached to a surface of the metallic nanoparticle. A biosensor comprising a plurality of the SERS marker conjugates and a method of forming the SERS marker conjugate is also provided.

公开(公告)号：EP3076860A4

公开(公告)日：2017-05-31

申请号：EP14868398

申请日：2014-12-08

申请人： AGENCY SCIENCE TECH & RES

发明人： OLIVO MALINI ,  HO JUN HUI ,  UNNIMADHAVA KURUP SOUDAMINI AMMA DINISH ,  WONG CHI LOK ,  BALASUNDARAM GHAYATHRI

IPC分类号： A61B5/00 ,  A61K41/00 ,  A61K49/22

CPC分类号： A61B5/0095 ,  A61B8/481 ,  A61K49/003 ,  A61K49/0036 ,  A61K49/0093 ,  A61K49/22 ,  G01N33/4833

摘要： A method of imaging living tissue is provided. The method includes introducing a photoacoustic contrast agent comprising or consisting of a photosensitizer into living tissue; and obtaining an image of the living tissue by photoacoustic imaging. Use of a photoacoustic contrast agent comprising or consisting of a photosensitizer in photoacoustic imaging is also provided.

摘要翻译： 提供了一种对活组织进行成像的方法。 该方法包括将包含光敏剂或由光敏剂组成的光声对比剂引入活组织中; 并通过光声成像获得活组织的图像。 还提供了在光声成像中使用包含光敏剂或由光敏剂组成的光声造影剂。

公开(公告)号：EP2550338A4

公开(公告)日：2014-03-05

申请号：EP11759810

申请日：2011-03-24

申请人： UNIV SINGAPORE ,  AGENCY SCIENCE TECH & RES

发明人： CHANG YOUNG-TAE ,  SAMANTA ANIMESH ,  VENDRELL MARC ,  KANG NAM-YOUNG ,  MAITI KAUSTABH KUMAR ,  SOH KIAT SENG ,  UNNIMADHAVA KURUP SOUDAMINI AMMA DINISH ,  OLIVO MALINI

IPC分类号： C09B23/08 ,  G01N33/52

CPC分类号： G01N21/658 ,  A61K49/0032 ,  A61K49/0058 ,  C09B23/0016 ,  C09B23/0041 ,  C09B23/0066 ,  C09B23/086 ,  G01N33/582

公开(公告)号：EP2580615A4

公开(公告)日：2017-11-29

申请号：EP11792753

申请日：2011-06-09

申请人： AGENCY SCIENCE TECH & RES

发明人： UNNIMADHAVA KURUP SOUDAMINI AMMA DINISH ,  FU CHIT YAW ,  OLIVO MALINI ,  SOH KIAT SENG JASON

IPC分类号： G02B6/02 ,  B82B1/00 ,  G01N21/65 ,  G02B6/036

CPC分类号： G01N21/658 ,  B82Y5/00 ,  B82Y15/00 ,  G01N21/7703 ,  G02B6/02328

摘要： A method for sensing, a photonic crystal fiber, a method for fabricating a photonic crystal fiber sensor, and a Surface Enhanced Raman Scattering (SERS) sensing apparatus. The method for sensing comprises the steps of providing a photonic crystal fiber comprising a hollow core and a plurality of cladding holes around the hollow core; providing Surface Enhanced Raman Scattering (SERS) active nanoparticles; and adapting the SERS active nanoparticles and/or the fiber for SERS sensing.

公开(公告)号：EP3043829A4

公开(公告)日：2017-04-26

申请号：EP14843282

申请日：2014-09-09

申请人： AGENCY SCIENCE TECH & RES ,  UNIV NANYANG TECH

发明人： OLIVO MALINI ,  KONG KIEN VOON ,  LEONG WENG KEE

IPC分类号： A61K49/22 ,  A61K31/28

CPC分类号： A61K49/22

摘要： A photoacoustic imaging contrast agent composition is provided. The composition comprises a metal carbonyl cluster compound having the general formula (I) M3(CO)xL12-x wherein M at each occurrence denotes a metal selected from Group 6 to Group 11 of the Periodic Table of Elements; x is an integer from 10 to 12; and each L is independently selected from the group consisting of —H and -A-(CH2)n—COO−Y+, wherein A is selected from the group consisting of S, O, C and N; n is an integer from 1 to 10; and Y is any cation. Use of the photoacoustic imaging contrast agent composition in photoacoustic imaging is also provided.

摘要翻译： 提供了一种光声成像造影剂组合物。 该组合物包含具有通式（I）M3（CO）xL12-x的金属羰基簇化合物，其中M在每次出现时表示选自元素周期表第6至第11族的金属; x是10至12的整数; 并且每个L独立地选自由-H和-A-（CH 2）n -COO-Y +组成的组，其中A选自由S，O，C和N组成的组; n是1至10的整数; Y是任何阳离子。 还提供了光声成像造影剂组合物在光声成像中的用途。