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1.发明授权COMPOSITIONS COMPRISING PHENYLAMINOTHIOPHENACETIC ACID DERIVATIVES FOR THE TREATMENT OF ACUTE OR ADULT RESPIRATORY DISTRESS SYNDROME (ARDS) AND INFANT RESPIRATORY DISTRESS SYNDROME (IRDS) 有权制备含PHENYLAMINOTHIOPHENESSIGSÄURE的衍生物对急性呼吸功能不全（ARDS）和急性呼吸功能不全IN儿童的治疗（IRDS）
公开(公告)号：EP1098645B1
公开(公告)日：2002-11-20
申请号：EP99931116.0
申请日：1999-06-19
申请人： ALTANA Pharma AG
IPC分类号： A61K31/381 , A61P11/00
CPC分类号： A61K31/38
摘要： Novel compositions for the treatment of IRDS and ARDS are indicated which contain a compound of formula (I), in which R1 is hydrogen or 2-(2-hydroxyethoxy)ethyl and/or a pharmacologically tolerable salt of this compound and lung surfactant.
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公开(公告)号：EP1131055B1
公开(公告)日：2005-11-09
申请号：EP99971701.0
申请日：1999-11-09
申请人： ALTANA Pharma AG
CPC分类号： A61K38/1709 , A61K9/0082
摘要： The invention describes a set for the treatment of IRDS, ALI or ARDS, comprising a first container which has a volume of 50 to 500 ml and contains a pulverulent pulmonary surfactant preparation, the amount of phospholipids in the container being 50 to 500 mg, and a second container which has a volume of 50 to 500 ml and contains a pulverulent pulmonary surfactant preparation, where the amount of phospholipids in the second container is 1 to 10 g.
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公开(公告)号：EP1075476B1
公开(公告)日：2003-06-04
申请号：EP99920814.3
申请日：1999-04-29
申请人： ALTANA Pharma AG
发明人： MARTIN, Thomas , ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , SCHMIDT,Beate , FLOCKERZI, Dieter , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KILIAN, Ulrich , KLEY, Hans-Peter , BÄR, Thomas
IPC分类号： C07D413/00 , A61K31/42 , A61K31/415 , C07D405/04 , C07D413/04 , C07D413/14
CPC分类号： C07D405/04 , C07D413/04 , C07D413/14
摘要： The invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and Y have the meanings given in the description. Said compounds are novel active bronchial therapeutic agents.
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4.发明授权COMPOSITIONS FOR THE TREATMENT OF ARDS OR IRDS CONTAINING 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLORO-4-PYRIDINYL)-4-(DIFLUOROMETHOXY)BENZAMIDE AND LUNG SURFACTANT 无效FOR治疗ARDS的组合物或IRDS 3-（CALCOPROPYLMETHOXY）-N-（3,5-二氯-4-吡啶基）-4-（二氟甲氧基）苯甲酰胺和肺表面活性剂CONTAIN
公开(公告)号：EP0977577B1
公开(公告)日：2006-08-16
申请号：EP98910670.3
申请日：1998-02-14
申请人： ALTANA Pharma AG
发明人： GERMANN, Paul-Georg , KILIAN, Ulrich , BEUME, Rolf , AMSCHLER, Hermann , KRÜGER, Uwe , HÄFNER, Dietrich , EISTETTER, Klaus
CPC分类号： A61K31/685 , A61K31/44 , A61K38/1709 , A61K45/06 , A61K2300/00
摘要： Composition for the treatment of infant or adult respiratory distress syndrome (IRDS and ARDS) contains N-(3,5-dichloropyrid-4-yl)-3- cyclopropylmethoxy-4- difluoromethoxybenzamide (II) (and/or its salts) and a lung surfactant.
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公开(公告)号：EP1176960B1
公开(公告)日：2004-09-29
申请号：EP00927094.3
申请日：2000-04-27
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , BEUME, Rolf , HÄFNER, Dietrich , SCHUDT, Christian , HATZELMANN, Armin , KILIAN, Ulrich
CPC分类号： A61K31/415 , A61K31/44 , A61K45/06 , A61K2300/00
摘要： The invention relates to the combined use of the PDE4 inhibitor N- (3,5-dichloropyrid-4-yl)- 3-cyclopropylmethoxy- 4-difluoromethoxybenzamide, its pharmacologically tolerable salts or its N- oxide with a PDE3 inhibitor for the treatment of certain disease conditions such as, for example, acute or chronic obstructions of the bronchi.
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6.发明授权ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON IRDS UND ARDS, DIE MINDESTENS EIN GLUCOCORTICOSTEROID IN KOMBINATION MIT EINEM LUNGEN SURFACTANT ENTHALTEN 失效组合物治疗IRDS和ARDS至少一个糖皮质激素结合肺含有表面活性剂
公开(公告)号：EP0783314B1
公开(公告)日：2003-05-28
申请号：EP95935387.1
申请日：1995-09-27
申请人： ALTANA Pharma AG
CPC分类号： A61K35/42 , A61K38/1709 , A61K31/58 , A61K31/57 , A61K2300/00
摘要： Novel compositions are disclosed for the treatment of IRDS and ARDS, containing at least one glucocorticosteroid and a pulmonary surfactant. The duration of treatment and the mortality associated with these syndromes can be significantly reduced with the proposed novel compositions.
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公开(公告)号：EP1212089B1
公开(公告)日：2006-03-22
申请号：EP00954625.0
申请日：2000-08-11
申请人： ALTANA Pharma AG
发明人： BEUME, Rolf , BUNDSCHUH, Daniela , HATZELMANN, Armin , SCHUDT, Christian , WEIMAR, Christian , KILIAN, Ulrich
IPC分类号： A61K31/138 , A61K31/44 , A61P11/00
CPC分类号： A61K31/44 , A61K31/138 , A61K31/4015 , A61K31/52 , A61K31/522 , A61K45/06 , A61K31/27 , A61K31/135 , A61K2300/00
摘要： The invention relates to the combined administration of PDE inhibitors and β2 adrenoceptor agonists for the treatment of respiratory tract disorders.
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8.发明授权BENZAMIDE MIT TETRAHYDROFURANYLOXY-SUBSTITUENTEN ALS INHIBITOREN DER PHOSPHODIESTERASE 4 有权与四氢呋喃氧基取代基苯甲酰作为抑制剂磷酸二酯酶4
公开(公告)号：EP1086096B1
公开(公告)日：2003-07-23
申请号：EP99926441.9
申请日：1999-05-27
申请人： ALTANA Pharma AG
发明人： MARTIN, Thomas , ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , SCHMIDT, Beate , FLOCKERZI, Dieter , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KILIAN, Ulrich , KLEY, Hans-Peter , BÄR, Thomas
IPC分类号： C07D405/12 , A61K31/44 , A61K31/34 , A61K31/35 , C07D493/10 , C07D307/20 , C07D309/10
CPC分类号： C07D405/12 , C07D493/10
摘要： Compounds of formula (I), wherein R1, R2, R3, R4, R5, m and n have the meanings cited in the description, are novel and effective PDE inhibitors.
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公开(公告)号：EP0988302B1
公开(公告)日：2003-02-19
申请号：EP98930737.6
申请日：1998-05-27
申请人： ALTANA Pharma AG
发明人： SCHMIDT, Beate , ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , BEUME, Rolf , HÄFNER, Dietrich , BÄR, Thomas , MARTIN, Thomas , KILIAN, Ulrich , ELTZE, Manfrid , BRAND, Ursula , BOSS, Hildegard , KLEY, Hans-Peter , SCHUDT, Christian , GOEBEL, Karl-Josef , FLOCKERZI, Dieter , HATZELMANN, Armin
IPC分类号： C07D471/04 , A61K31/47
CPC分类号： C07D471/04
摘要： The invention concerns the compounds 8,9-Diethoxy-2-methyl-6- [4(p-toluenesulfonamido)phenyl] -1,2,3,4,4a,10b-hexahydrobenzo[c] [1,6]naphthyridine and 9-Ethoxy-8-methoxy-2- methyl-6-[4-(p-toluenesulfonamido) phenyl]-1,2,3,4,4a,10b-hexahydrobenzo [c][1,6]naphthyridine and their therapeutic application.
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