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公开(公告)号：EP1429807B1
公开(公告)日：2007-02-28
申请号：EP02772313.9
申请日：2002-09-17
申请人： ALTANA Pharma AG
CPC分类号： A61K45/06 , A61K31/00 , A61K2300/00
摘要： The invention relates to the combined administration of PDE4-inhibitors and NSAIDs for the treatment of an inflammatory disease and/or an inflammation associated disorder while minimizing gastrointesti-nal side effects, such as gastric erosions and ulcer, which are frequently associated with the use of NSAIDs.
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公开(公告)号：EP1670796A1
公开(公告)日：2006-06-21
申请号：EP04787262.7
申请日：2004-09-30
申请人： ALTANA Pharma AG
发明人： ULRICH, Wolf-Ruediger , FUCHSS, Thomas , MARTIN, Thomas , BOER, Rainer , STRUB, Andreas , ELTZE, Manfrid , LEHNER, Martin
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61P25/00 , A61P29/00 , A61P31/00 , C07D519/00
CPC分类号： C07D471/04
摘要： The compounds of formula (I) in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors.
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公开(公告)号：EP1429807A2
公开(公告)日：2004-06-23
申请号：EP02772313.9
申请日：2002-09-17
申请人： ALTANA Pharma AG
CPC分类号： A61K45/06 , A61K31/00 , A61K2300/00
摘要： The invention relates to the combined administration of PDE4-inhibitors and NSAIDs for the treatment of an inflammatory disease and/or an inflammation associated disorder while minimizing gastrointesti-nal side effects, such as gastric erosions and ulcer, which are frequently associated with the use of NSAIDs.
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公开(公告)号：EP1670798A1
公开(公告)日：2006-06-21
申请号：EP04820599.1
申请日：2004-09-30
申请人： Altana Pharma AG
发明人： FUCHSS, Thomas , BOER, Rainer , MARX, Degenhard , ULRICH, Wolf-Ruediger , ELTZE, Manfrid , NAVE, Ruediger , STRUB, Andreas , GRAEDLER, Ulrich
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61P25/00 , A61P29/00 , A61P31/00
CPC分类号： C07D471/04
摘要： The compounds of formula (I) in which R1, R2, R3 and R4 the meanings as given in the description are novel effective iNOS inhibitors.
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公开(公告)号：EP1490366A1
公开(公告)日：2004-12-29
申请号：EP03744851.1
申请日：2003-03-25
申请人： ALTANA Pharma AG
发明人： ULRICH, Wolf-Rüdiger , BOER, Rainer , MARX, Degenhard , ELTZE, Manfrid , KLEIN, Thomas , NAVE, Rüdiger , GRÄDLER, Ulrich , FUCH , Thomas , BARSIG, Johannes
IPC分类号： C07D471/04 , C07D473/00 , A61K31/4427 , A61K31/52 , A61P25/00
CPC分类号： C07D471/04 , C07D473/00
摘要： The compounds of formula (I) in which R1 is 1-4C-alkoxy, , A is 1-4C-alkylene, B represents 3H-imidazo (4,5b) pyridin-2-yl, 3H-imidazo (4,5-b) pyridin-2-yl substituted by R2 and/or R8, 9H-purin-8yl or 9H-purin-8-yl substituted by R4 and/or R5 are effective iNOS inhibitors.
摘要翻译： 其中R1是1-4C-烷氧基，A是1-4C-亚烷基，B代表3H-咪唑并（4,5b）吡啶-2-基，3H-咪唑并（4,5- b）由R 2和/或R 8取代的吡啶-2-基，由R 4和/或R 5取代的9H-嘌呤-8基或9H-嘌呤-8-基是有效的iNOS抑制剂。
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公开(公告)号：EP1673371A1
公开(公告)日：2006-06-28
申请号：EP04787261.9
申请日：2004-09-30
申请人： ALTANA Pharma AG
发明人： ULRICH, Wolf-Ruediger , FUCHSS, Thomas , MARTIN, Thomas , BOER, Rainer , STRUB, Andreas , ELTZE, Manfrid , LEHNER, Martin , MARX, Degenhard
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61P25/00 , A61P29/00 , A61P31/00
CPC分类号： C07D471/04
摘要： The compounds of formula (I) in which R1, R2, Het1 and A have the meanings as given in the description are novel effective iNOS inhibitors.
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7.发明公开COMPOUNDS EFFECTIVE AS BETA-2-ADRENORECEPTOR AGONISTS AS WELL AS PDE4-INHIBITORS 审中-公开ALSβ-2肾上腺素受体激动剂和ALS PDE4抑制剂起作用的化合物
公开(公告)号：EP1296956A1
公开(公告)日：2003-04-02
申请号：EP01936419.9
申请日：2001-06-01
申请人： ALTANA Pharma AG , Byk Nederland BV
发明人： HATZELMANN, Armin , BUNDSCHUH, Daniela , ELTZE, Manfrid , VAN DER LAAN, Yvonne , TIMMERMANN, Hendrik , CHRISTIAANS, Johannes , BRUNDEL, Paulus , STERK, Geert
IPC分类号： C07D237/14 , C07D237/22 , C07D237/32 , C07D405/04 , A61K31/50 , A61K31/501 , A61K31/502 , A61P11/06
CPC分类号： C07D401/04 , C07D237/32 , C07D405/04
摘要： The compounds of formula I in which Ar1, A, R6, R7, R8 and Ar2 have the meanings as given in the description are novel effective bronchial therapeutics.
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公开(公告)号：EP1675854A1
公开(公告)日：2006-07-05
申请号：EP04787263.5
申请日：2004-09-30
申请人： ALTANA Pharma AG
发明人： ULRICH, Wolf-Ruediger , FUCHSS, Thomas , MARTIN, Thomas , BOER, Rainer , STRUB, Andreas , ELTZE, Manfrid , LEHNER, Martin
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61P25/00 , A61P29/00 , A61P31/00
CPC分类号： C07D471/04 , A61K31/437
摘要： The compounds of formula (I) in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors.
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公开(公告)号：EP0988302B1
公开(公告)日：2003-02-19
申请号：EP98930737.6
申请日：1998-05-27
申请人： ALTANA Pharma AG
发明人： SCHMIDT, Beate , ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , BEUME, Rolf , HÄFNER, Dietrich , BÄR, Thomas , MARTIN, Thomas , KILIAN, Ulrich , ELTZE, Manfrid , BRAND, Ursula , BOSS, Hildegard , KLEY, Hans-Peter , SCHUDT, Christian , GOEBEL, Karl-Josef , FLOCKERZI, Dieter , HATZELMANN, Armin
IPC分类号： C07D471/04 , A61K31/47
CPC分类号： C07D471/04
摘要： The invention concerns the compounds 8,9-Diethoxy-2-methyl-6- [4(p-toluenesulfonamido)phenyl] -1,2,3,4,4a,10b-hexahydrobenzo[c] [1,6]naphthyridine and 9-Ethoxy-8-methoxy-2- methyl-6-[4-(p-toluenesulfonamido) phenyl]-1,2,3,4,4a,10b-hexahydrobenzo [c][1,6]naphthyridine and their therapeutic application.
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10.发明公开IMIDAZO(4,5-B)PYRIDINE-DERIVATIVES AS INDUCIBLE NO-SYNTHASE INHIBITORS 有权咪唑并[4,5-b]吡啶衍生物作为可诱导的NO合酶的抑制剂
公开(公告)号：EP1675853A1
公开(公告)日：2006-07-05
申请号：EP04787257.7
申请日：2004-09-30
申请人： ALTANA Pharma AG
发明人： FUCHSS, Thomas , BOER, Rainer , ULRICH, Wolf-Ruediger , ELTZE, Manfrid , MARX, Degenhard , GRAEDLER, Ulrich
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61P25/00 , A61P29/00 , A61P31/00
CPC分类号： C07D471/04
摘要： The compounds of formula (I) in which R1, R2, R3, R4 and R11 the meanings as given in the description are novel effective iNOS inhibitors.
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