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公开(公告)号：EP0181117A2
公开(公告)日：1986-05-14
申请号：EP85307634.7
申请日：1985-10-23
IPC分类号： A61K39/295 , A61K39/235 , A61K39/29 , A61K39/12
CPC分类号： C12N7/00 , A61K39/00 , C12N15/86 , C12N2710/10243 , C12N2710/10251 , C12N2710/10322 , C12N2710/10343 , C12N2720/12322 , C12N2720/12334 , C12N2730/10134 , C12N2740/16322 , C12N2740/16334 , Y02A50/464 , Y02A50/472
摘要： Vaccines for the production of antibodies to infectious organisms are described. Live recombinant adenovirus containing a foreign gene coding for an antigen produced by another infectious organism is delivered to the intestine of a warm-blooded animal in an enteric-coated dosage farm, whereupon the virus infects the gut wall and induces the production of antibodies or cell mediated immunity to both adenovirus and the other infectious organism
摘要翻译： 描述了用于产生感染性生物体的抗体的疫苗。 将含有编码另一感染性生物体产生的抗原的外源基因的活重组腺病毒递送至肠溶包衣剂型农场中温血动物的肠道，于是病毒感染肠壁并诱导产生抗体或细胞 介导的对腺病毒和其他感染性生物体的免疫
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公开(公告)号：EP0181117A3
公开(公告)日：1987-01-21
申请号：EP85307634
申请日：1985-10-23
IPC分类号： A61K39/295 , A61K39/235 , A61K39/29 , A61K39/12 , C12N15/00
CPC分类号： C12N7/00 , A61K39/00 , C12N15/86 , C12N2710/10243 , C12N2710/10251 , C12N2710/10322 , C12N2710/10343 , C12N2720/12322 , C12N2720/12334 , C12N2730/10134 , C12N2740/16322 , C12N2740/16334 , Y02A50/464 , Y02A50/472
摘要： Vaccines for the production of antibodies to infectious organisms are described. Live recombinant adenovirus containing a foreign gene coding for an antigen produced by another infectious organism is delivered to the intestine of a warm-blooded animal in an enteric-coated dosage farm, whereupon the virus infects the gut wall and induces the production of antibodies or cell mediated immunity to both adenovirus and the other infectious organism
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公开(公告)号：EP0586076A3
公开(公告)日：1994-04-20
申请号：EP93305833.1
申请日：1993-07-23
发明人： Davis, Alan Robert , Hunt, Paul Porwen , Lubeck, Micheal David , Natuk, Robert James , Chanda, Pranab Kumar , Murthy, Shridhara Chikkatur Shankaranarayana , Lee, Shaw-Guang Lin
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C12N2710/10343 , C12N2740/16134 , C12N2740/16234 , Y02A50/464 , Y02A50/472
摘要： The production of antibodies or cell mediated immunity to an infectious organism in a warm blooded mammal is disclosed. The production comprises administering to the said warm blooded mammal intranasally, intramuscularly, or subcutaneously, live recombinant adenoviruses in which the virion structural protein is unchanged from that in the native adenovirus from which the recombinant adenovirus is produced, and which contain the gene coding for the antigen corresponding to said antibodies or inducing said cell mediated immunity. Vaccines containing the live recombinant adenoviruses are also described. Some of the recombinant adenoviruses are new per se .
摘要翻译： 公开了在温血哺乳动物中产生对传染性生物体的抗体或细胞介导的免疫性。 所述生产包括鼻内，肌肉内或皮下给予所述温血哺乳动物活的重组腺病毒，其中病毒粒子结构蛋白与产生重组腺病毒的天然腺病毒中的病毒粒子结构蛋白相同并且含有编码 对应于所述抗体的抗原或诱导所述细胞介导的免疫。 还描述了含有活重组腺病毒的疫苗。 一些重组腺病毒本身是新的。
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公开(公告)号：EP0181117B1
公开(公告)日：1992-11-19
申请号：EP85307634.7
申请日：1985-10-23
IPC分类号： A61K39/295 , A61K39/235 , A61K39/29 , A61K39/12
CPC分类号： C12N7/00 , A61K39/00 , C12N15/86 , C12N2710/10243 , C12N2710/10251 , C12N2710/10322 , C12N2710/10343 , C12N2720/12322 , C12N2720/12334 , C12N2730/10134 , C12N2740/16322 , C12N2740/16334 , Y02A50/464 , Y02A50/472
摘要： Vaccines for the production of antibodies to infectious organisms are described. Live recombinant adenovirus containing a foreign gene coding for an antigen produced by another infectious organism is delivered to the intestine of a warm-blooded animal in an enteric-coated dosage farm, whereupon the virus infects the gut wall and induces the production of antibodies or cell mediated immunity to both adenovirus and the other infectious organism
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公开(公告)号：EP0586076A2
公开(公告)日：1994-03-09
申请号：EP93305833.1
申请日：1993-07-23
发明人： Davis, Alan Robert , Hunt, Paul Porwen , Lubeck, Micheal David , Natuk, Robert James , Chanda, Pranab Kumar , Murthy, Shridhara Chikkatur Shankaranarayana , Lee, Shaw-Guang Lin
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C12N2710/10343 , C12N2740/16134 , C12N2740/16234 , Y02A50/464 , Y02A50/472
摘要： The production of antibodies or cell mediated immunity to an infectious organism in a warm blooded mammal is disclosed. The production comprises administering to the said warm blooded mammal intranasally, intramuscularly, or subcutaneously, live recombinant adenoviruses in which the virion structural protein is unchanged from that in the native adenovirus from which the recombinant adenovirus is produced, and which contain the gene coding for the antigen corresponding to said antibodies or inducing said cell mediated immunity. Vaccines containing the live recombinant adenoviruses are also described. Some of the recombinant adenoviruses are new per se .
摘要翻译： 公开了在温血哺乳动物中产生针对感染性生物体的抗体或细胞介导的免疫。 生产包括向所述温血哺乳动物鼻内，肌肉内或皮下施用活重组腺病毒，其中病毒结构蛋白与产生重组腺病毒的天然腺病毒中的病毒结构蛋白不变，并且其含有编码 对应于所述抗体的抗原或诱导所述细胞介导的免疫。 还描述了含有活重组腺病毒的疫苗。 一些重组腺病毒是新的本身。
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