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    A hydrophilic cationic charge modified microporous membrane, a process for producing it and its use
    3.
    发明公开
    A hydrophilic cationic charge modified microporous membrane, a process for producing it and its use 失效
    亲水微孔膜具有改性cationischer电荷，产生它和它的使用方法。

    公开(公告)号：EP0050864A1

    公开(公告)日：1982-05-05

    申请号：EP81108827.7

    申请日：1981-10-23

    申请人： AMF INCORPORATED

    发明人： Ostreicher, Eugene A. ,  Knight, Rodney, A. ,  Fiore, Joseph V. ,  Emond, George T. ,  Hou, Kenneth C.

    IPC分类号： B01D13/04 ,  C08J5/22

    CPC分类号： B01D67/0093 ,  A61K35/14 ,  A61K35/16 ,  A61L2/0017 ,  A61L2/022 ,  B01D67/0011 ,  B01D71/56 ,  B01D2323/08 ,  B01D2323/30 ,  B01D2325/14 ,  B01D2325/36

    摘要： A novel cationic charge modified microporous membrane is provided comprising a hydrophilic organic polymeric microporous membrane and a charge modifying amount of a primary cationic charge modifying agent bonded to substantially all of the wetted surfaces of the membrane. The primary charge modifying agent is a water soluble organic polymer having a molecular weight greater than about 1000 wherein each monomer thereof has at least one epoxide group capable of bonding to the surface of the membrane and at least one tertiary amine or quaternary ammonium group Preferably, a portion of the epoxy groups on the organic polymer are bonded to a secondary charge modifying agent selected from the group consisting of:

    i) aliphatic amines having at least one primary amine or at least two secondary amines; and
    ii) aliphatic amines having at least one secondary amine and a carboxyl or hydroxyl substituent.

    The invention is further directed to a process for cationically charge modifying a hydrophilic organic polymeric microporous membrane by applying to the membrane the aforesaid charge modifying agents, preferably, by contacting the membrane with aqueous solutions of the charge modifying agents.
    The preferred microporous membrane is nylon, the preferred primary and secondary charge modifying agents are, respectively, polyamido-polyamine epichlorohydrin and tetraethylene pentamine.
    The invention is further directed to a process for improving the responsiveness of a nylon membrane to charge modification, comprising chemically treating the membrane to provide enhanced ninhydrin response evidencing free amino functionality.
    The charge modified microporous membrane of this invention may be used for the filtration of fluids, particularly parenteral or biological liquids. The membrane has low extractables and is sanitizable or sterilizable.

    摘要翻译： 一种新的阳离子电荷改性微孔膜提供了一种包括亲水性有机聚合物微孔膜和电荷改性结合到基本上所有的膜的湿润表面的主要阳离子电荷改性剂的量。 主电荷改性剂是具有分子量小于约1000 worin其每种单体具有与膜的表面能够键合至少一个环氧基团和至少一个叔胺或季铵基团更大的水溶性有机聚合物。 优选地，在有机聚合物的环氧基的一部分被结合到次级电荷改性选自下组的选择剂：i）具有至少一个伯胺或至少两个仲脂肪族cardamines cardamines; 和ii）具有至少一个仲胺和羧基或羟基取代基的脂肪族胺。 本发明还涉及一种用于阳离子电荷通过施加到膜的前述的电荷改性剂，优选地，通过接触与所述电荷改性剂的溶液wässrige膜改性的亲水性有机聚合物微孔膜。 优选的微孔膜是尼龙，优选的主要和次要电荷改性剂分别是聚氨基聚胺和表氯醇四乙烯五矿。 本发明还涉及一种用于改善尼龙膜的响应充电变形例中，包括化学处理膜以提供增强的茚三酮反应，证明上游离氨基的功能。 本发明的电荷改性微孔膜可以用于流体，特别是胃肠外或生物液体的过滤。 该膜具有低的可提取物和消毒的是灭菌或。

    Molecular separation column and use thereof
    4.
    发明公开
    Molecular separation column and use thereof 失效
    分子分离柱及其用途

    公开(公告)号：EP0047617A3

    公开(公告)日：1982-03-31

    申请号：EP81303969

    申请日：1981-09-01

    申请人： AMF INCORPORATED

    发明人： Crowder III, Alvin L. ,  Hou, Kenneth C. ,  Dailey, Nils L. ,  Marinaccio, Paul J. ,  Fiore, Joseph V. ,  Ostreicher, Eugene A.

    IPC分类号： B01J20/28 ,  B01D15/08 ,  G01N31/06

    CPC分类号： B01J20/282 ,  B01D15/22 ,  B01J20/28004 ,  B01J20/28028 ,  B01J20/28033 ,  B01J20/28052 ,  B01J2220/54 ,  G01N30/56 ,  G01N2030/527

    摘要： A molecular separation column is provided for effecting differential distribution, between two phases, of the components of a sample flowing therethrough, said column containing a solid stationary phase which comprises a porous matrix of fiber having particulate immobilized therein, at least one of said fiber or particulate being effective for molecular separation, preferably the particulate, the matrix being substantially i homogeneous with respect to each component. When used in liquid-solid flow-through molecular separations, there is a reduced pressure drop and diffusional resistance so that the columns can be used for commercial scale liquid separations in addition to analytical separations. A method is also provided for effecting molecular separations by the use of such columns as well as providing for a solid phase for use in such columns.

    摘要翻译： 分子分离色谱柱，用于实现在两相之间的样品流动的分量的差分分布。 该柱包含基本均匀的固体固定相，其包含其中固定有颗粒的纤维的多孔基质，其中所述纤维或颗粒中的至少一种对分子分离是有效的。 该柱的特征在于降低的压降，增加的轴向分散，更均匀的峰形和更高的样品加载时的分离。

    A hydrophilic cationic charge modified microporous membrane, a process for producing it and its use
    10.
    发明授权
    A hydrophilic cationic charge modified microporous membrane, a process for producing it and its use 失效
    水解阳离子电荷改性微孔膜，其制备方法及其用途

    公开(公告)号：EP0050864B1

    公开(公告)日：1985-01-09

    申请号：EP81108827.7

    申请日：1981-10-23

    申请人： AMF INCORPORATED

    发明人： Ostreicher, Eugene A. ,  Knight, Rodney, A. ,  Fiore, Joseph V. ,  Emond, George T. ,  Hou, Kenneth C.

    IPC分类号： B01D13/04 ,  C08J5/22

    CPC分类号： B01D67/0093 ,  A61K35/14 ,  A61K35/16 ,  A61L2/0017 ,  A61L2/022 ,  B01D67/0011 ,  B01D71/56 ,  B01D2323/08 ,  B01D2323/30 ,  B01D2325/14 ,  B01D2325/36

    摘要： A novel cationic charge modified microporous membrane is provided comprising a hydrophilic organic polymeric microporous membrane and a charge modifying amount of a primary cationic charge modifying agent bonded to substantially all of the wetted surfaces of the membrane. The primary charge modifying agent is a water soluble organic polymer having a molecular weight greater than about 1000 wherein each monomer thereof has at least one epoxide group capable of bonding to the surface of the membrane and at least one tertiary amine or quaternary ammonium group. Preferably, a portion of the epoxy groups on the organic polymer are bonded to a secondary charge modifying agent selected from the group consisting of: i) aliphatic amines having at least one primary amine or at least two secondary amines; and ii) aliphatic amines having at least one secondary amine and a carboxyl or hydroxyl substituent. The invention is further directed to a process for cationically charge modifying a hydrophilic organic polymeric microporous membrane by applying to the membrane the aforesaid charge modifying agents, preferably, by contacting the membrane with aqueous solutions of the charge modifying agents. The preferred microporous membrane is nylon, the preferred primary and secondary charge modifying agents are, respectively, polyamido-polyamine epichlorohydrin and tetraethylene pentamine. The invention is further directed to a process for improving the responsiveness of a nylon membrane to charge modification, comprising chemically treating the membrane to provide enhanced ninhydrin response evidencing free amino functionality. The charge modified microporous membrane of this invention may be used for the filtration of fluids, particularly parenteral or biological liquids. The membrane has low extractables and is sanitizable or sterilizable.