公开(公告)号：EP2389580A1

公开(公告)日：2011-11-30

申请号：EP09767965.8

申请日：2009-12-02

申请人： Sartorius Stedim Biotech GmbH

发明人： GÓRAK, Andrzej ,  KREIS, Peter ,  VAN BEIJEREN BERGEN EN HENEGOUWEN, Peter ,  FABER, René ,  DEMMER, Wolfgang ,  FRERICK, Constantin

IPC分类号： G01N30/46 ,  C07K1/36 ,  G01N33/543

CPC分类号： G01N30/461 ,  C07K1/20 ,  C07K1/22 ,  G01N30/52 ,  G01N2030/527

摘要： The present invention relates to a device for separating or isolating substances in or from a mixture, wherein the device comprises at least one diffusively operating chromatography matrix and at least one convectively operating chromatography matrix. The present invention further relates to both the use of said device and to a method for separating and/or isolating substances in or from a mixture.

摘要翻译： 本发明涉及用于分离或分离混合物中物质的装置，其中该装置包括至少一个扩散操作色谱基质和至少一个对流操作色谱基质。 本发明进一步涉及所述装置的用途以及用于分离和/或分离混合物中或来自混合物的物质的方法。

公开(公告)号：EP1957969A2

公开(公告)日：2008-08-20

申请号：EP06850772.2

申请日：2006-11-17

申请人： PALL CORPORATION

发明人： NOCHUMSON, Samuel ,  LEVISON, Peter

IPC分类号： G01N30/89 ,  B01D65/10

CPC分类号： G01N30/89 ,  G01N30/6091 ,  G01N2030/889 ,  G01N2030/528 ,  G01N2030/527

摘要： Methods for testing the chromatography type and/or the integrity of a chromatography membrane or monolith, preferably, for testing the chromatography type and integrity of a chromatography device comprising a chromatography membrane or chromatography monolith while the membrane or monolith is sealed in a housing, are disclosed.

摘要翻译： 用于测试层析类型和/或色谱膜或整料的完整性的方法，优选用于测试包括色谱膜或色谱单块的色谱装置的色谱类型和完整性，同时将膜或整料密封在壳体中 披露。

公开(公告)号：EP1475635A1

公开(公告)日：2004-11-10

申请号：EP04252640.0

申请日：2004-05-06

申请人： Patheon Inc.

发明人： Guo, Junan, c/o Patheon Inc. ,  He, Ping, c/o Patheon Inc. ,  Qu, Anthony Yi, c/o Patheon Inc. ,  Yang, Steve Yong-Tao, c/o Patheon Inc. ,  Anik, Shabbir, c/o Patheon Inc.

IPC分类号： G01N30/52 ,  G01N30/86 ,  G01N15/08 ,  G01N33/543

CPC分类号： G01N30/8693 ,  G01N15/08 ,  G01N30/89 ,  G01N2030/527

摘要： The present invention provides a method for determining drug permeability, wherein the method comprises, for each reference drug of at least two reference drugs having (i) the same ionization state at a given pH and (ii) a known drug permeability determined by the same drug permeability testing technique, the calculation of a metric related to retention time of each reference compound eluted from a liquid chromatography column having an immobilized artificial membrane functional group. Then, based on each metric and each known drug permeability, drug permeability is expressed as a function of the metric. The method may further comprise the calculation of the metric related to retention time for a further drug eluted from the liquid chromatography column, the further drug having the same ionization state at the given pH and an unknown drug permeability, and an assessment of drug permeability for the further drug, based on the metric for the further drug and the function.

摘要翻译： 本发明提供了一种用于测定药物渗透性的方法，其中所述方法对于每种参考药物包含至少两种参考药物，所述参考药物具有（i）在给定pH下具有相同的电离状态，和（ii）由相同的 药物渗透性检测技术，计算与具有固定化人造膜官能团的液相色谱柱洗脱的各参考化合物的保留时间有关的度量。 然后，基于每个度量和每个已知的药物渗透性，药物通透性被表示为度量的函数。 该方法可以进一步包括与从液相色谱柱洗脱的另外药物的保留时间相关的度量的计算，所述另外的药物在给定pH下具有相同的电离状态和未知的药物通透性，以及药物通透性的评估 进一步的药物，基于进一步的药物和功能的指标。

公开(公告)号：EP1064316A1

公开(公告)日：2001-01-03

申请号：EP99908336.3

申请日：1999-02-23

申请人： RETT Corporation

发明人： WAINER, Irving ,  ZHANG, Yanxiano

IPC分类号： C08G63/48 ,  C08L89/00 ,  A23J1/00

CPC分类号： B01D15/3804 ,  B01J20/28033 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3242 ,  B01J20/3246 ,  B01J20/3251 ,  B01J20/3274 ,  B01J2220/54 ,  B01J2220/58 ,  G01N30/02 ,  G01N30/48 ,  G01N30/7233 ,  G01N30/89 ,  G01N2030/527

摘要： This invention provides immobilized receptors on supports in liquid chromatographic systems. The method of the invention provides means of evaluating the attachment of agents to receptors comprising the steps of: (a) immobilizing receptors on artificial membrane supports in a column, (b) exposing the supports with the receptors to test agents at varying concentrations in a liquid chromatographic system, (c) eluting the test agent from the column, and (d) evaluating the elution profile of the test materials from the column. Using this method, it is possible to evaluate the interaction of the test agent with the receptor. Following elution, it is possible to directly determine molecular structure by passing the elute through other testing devices such as a mass spectrometer.

公开(公告)号：EP1004025A1

公开(公告)日：2000-05-31

申请号：EP99931860.3

申请日：1999-06-23

申请人： Chen & Chen, LLC

发明人： CHEN, Shuqi

IPC分类号： G01N35/02 ,  G01N33/52

CPC分类号： G01N35/02 ,  G01N30/6082 ,  G01N33/54366 ,  G01N2030/527 ,  G01N2035/1055

摘要： A multi-layer testing column has a chamber having a longitudinal axis and a first end having a first aperture. A plurality of membrane layers are vertically stacked within the chamber and include at least a plurality of solid-phase substrates each carrying a different anti-analyte. A sample can be placed in the chamber such that specific analytes of the sample are bound to the anti-analytes. A sensor can then be used to receive a signal from the substrates and to generate a corresponding electrical signal.

公开(公告)号：EP0777725A1

公开(公告)日：1997-06-11

申请号：EP95931184.0

申请日：1995-08-22

申请人： Josic, Djuro

发明人： JOSIC, Djuro ,  KOSELJ, Primoz ,  PODGRONIK, Ales ,  STRANCAR, Ales

IPC分类号： B01D15 ,  C12M1 ,  C12M3 ,  G01N30 ,  B01J20

CPC分类号： B01J20/3242 ,  B01D15/1821 ,  B01D15/1892 ,  B01D15/22 ,  B01J20/28014 ,  B01J20/28042 ,  G01N30/02 ,  G01N30/6017 ,  G01N30/6069 ,  G01N2030/324 ,  G01N2030/386 ,  G01N2030/527 ,  B01D2015/389

摘要： A process for the conversion of substrates both for analytical and preparative purposes in a flow-through and cross-flow reactor having compact porous discs and/or compact porous tubes as carrier for conversion reaction or preparative separations which compact porous discs and/or compact porous tubes are modified with substances being capable of specifically binding and/or converting said substrates by distributing the samples to be converted and/or preparatively separated and collecting the converted and/or separated substrates preferably in a low volume, wherein the distribution of the sample does not affect the carrier adversely.

公开(公告)号：EP0483143B2

公开(公告)日：1997-04-09

申请号：EP89912702.1

申请日：1989-10-30

申请人： SEPRACOR, INC.

发明人： GOFFE, Randal, A. ,  ZALE, Stephen, E. ,  O'CONNOR, James, L. ,  KESSLER, Stephen, B. ,  COHEN, Charles, M.

IPC分类号： B01D63/02 ,  B01D63/04 ,  B01D63/08

CPC分类号： B01D15/08 ,  B01D15/3804 ,  B01D61/00 ,  B01D63/02 ,  B01D63/043 ,  B01D67/0009 ,  B01D67/0093 ,  B01D69/08 ,  B01D69/085 ,  B01D69/141 ,  B01D2313/243 ,  B01D2323/38 ,  B01D2325/36 ,  B01D2325/38 ,  C07K1/22 ,  C07K14/745 ,  C07K14/755 ,  C07K14/78 ,  C07K16/00 ,  C07K16/065 ,  C07K16/36 ,  C07K16/40 ,  C07K16/44 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/50 ,  C07K2319/705 ,  C12N9/644 ,  C12Y304/21022 ,  G01N2030/527 ,  G01N2030/528

摘要： The invention relates to an apparatus useful for the separation of at least one preselected ligate present in a fluid. The invention also features an easily scaled-up membrane affinity separation process which is highly reliable, highly selective, provides a high yield of product, and is further characterized by a high volumetric throughput. The invention utilizes a substantially isotropic porous membrane, to which is associated a preselected ligand, which provides an optimum loading capacity and low dead volume while allowing high filtrate flow rates. Methods for isolating macromolecules having therapeutic value are described.

公开(公告)号：EP0588564B1

公开(公告)日：1996-11-13

申请号：EP93307141.7

申请日：1993-09-10

申请人： AMERSHAM INTERNATIONAL plc

发明人： Raybuck, Margaret Patricia ,  Kenrick, Michael Kenneth ,  Parry, David Alun

IPC分类号： B01D15/00 ,  G01N30/00 ,  G01N33/543

CPC分类号： B01L3/0275 ,  B01D15/00 ,  B01D15/3804 ,  B01J2220/54 ,  G01N1/405 ,  G01N30/48 ,  G01N30/6065 ,  G01N33/54366 ,  G01N2030/527 ,  G01N2035/0434 ,  G01N2035/1055

公开(公告)号：EP0320023B1

公开(公告)日：1994-09-21

申请号：EP88120747.6

申请日：1988-12-12

申请人： Ceskoslovenska akademie ved ,  AKADEMIA NAUK SSSR

发明人： Svec, Frantisek, Dipl.-Ing., Dr.sc. ,  Bleha, Miroslav, Dipl.-Ing.CSc ,  Tennikova, Tatiana Borisovna CSc ,  Belenkii, Boris Grigorijevic DrSc

IPC分类号： B01D15/00 ,  B01D15/08 ,  G01N30/48

CPC分类号： B01D67/0006 ,  B01D67/0093 ,  B01D71/28 ,  B01D71/40 ,  B01D71/76 ,  B01D2323/02 ,  B01D2323/30 ,  B01D2325/10 ,  B01D2325/40 ,  B01J20/26 ,  B01J20/261 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28026 ,  B01J20/28033 ,  B01J20/28057 ,  B01J20/28085 ,  B01J20/285 ,  B01J20/3064 ,  B01J2220/54 ,  C12N9/00 ,  G01N2030/527 ,  Y10S264/48 ,  Y10S264/62

公开(公告)号：EP0320023A3

公开(公告)日：1991-07-24

申请号：EP88120747.6

申请日：1988-12-12

申请人： Ceskoslovenska akademie ved ,  AKADEMIA NAUK SSSR

发明人： Svec, Frantisek, Dipl.-Ing., Dr.sc. ,  Bleha, Miroslav, Dipl.-Ing.CSc ,  Tennikova, Tatiana Borisovna CSc ,  Belenkii, Boris Grigorijevic DrSc

IPC分类号： B01D15/00 ,  B01D15/08 ,  G01N30/48

CPC分类号： B01D67/0006 ,  B01D67/0093 ,  B01D71/28 ,  B01D71/40 ,  B01D71/76 ,  B01D2323/02 ,  B01D2323/30 ,  B01D2325/10 ,  B01D2325/40 ,  B01J20/26 ,  B01J20/261 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28026 ,  B01J20/28033 ,  B01J20/28057 ,  B01J20/28085 ,  B01J20/285 ,  B01J20/3064 ,  B01J2220/54 ,  C12N9/00 ,  G01N2030/527 ,  Y10S264/48 ,  Y10S264/62

摘要： The invention relates to macroporous polymeric membranes, their preparation and their use for polymer separation. The membranes consist of a cross-linked copolymer on the basis of one or more monovinylic monomers and one or more cross-linking agents and has a globular microstructure whereby the globular structures have a size of 0,05 to 0,5 µm and are mutually interconnected by covalent bonds, and between the globular structures are mutally communicating pores. The thickness is 0,2 to 15 mm, and the specific surface area is up to 400 m²/g. They are prepared by polymerizing a corresponding monomer mixture including the polymerization initiator in solution in a porogenic solvent in a temperature-controlled mould of appropriate inner dimensions. The macroporous membranes are particularly suited for the separation of synthetic polymers and biopolymers with gradient elution.