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公开(公告)号：EP2301961B1
公开(公告)日：2017-02-22
申请号：EP10014373.4
申请日：2006-04-28
申请人： Amgen Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
摘要翻译： 本发明涉及硬骨素的多肽片段和结合该片段的抗体。 该抗体可用于治疗骨密度低的疾病，如骨质疏松症，以及加速骨折愈合。
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公开(公告)号：EP2336163A1
公开(公告)日：2011-06-22
申请号：EP10014375.9
申请日：2006-04-28
申请人： UCB Pharma S.A. , Amgen, Inc
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Popplewell, Andy , Shen, Wenyan , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：EP2298800B1
公开(公告)日：2016-11-30
申请号：EP10014361.9
申请日：2006-04-28
申请人： Amgen Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
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公开(公告)号：EP2325199B1
公开(公告)日：2015-03-04
申请号：EP10014362.7
申请日：2006-04-28
申请人： AMGEN, INC.
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Winters, Aaron George , Winkler, David , Shen, Wenyan , Popplewell, Andy
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
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公开(公告)号：EP2345668A1
公开(公告)日：2011-07-20
申请号：EP10014360.1
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen, Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
摘要翻译： 本发明涉及结合片段的硬化蛋白的多肽片段和抗体。 该抗体可用于治疗低骨密度疾病，如骨质疏松症，以及加速骨折愈合。
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公开(公告)号：EP2298800A1
公开(公告)日：2011-03-23
申请号：EP10014361.9
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen, Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
摘要翻译： 本发明涉及结合片段的硬化蛋白的多肽片段和抗体。 该抗体可用于治疗低骨密度疾病，如骨质疏松症，以及加速骨折愈合。
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公开(公告)号：EP2325200A1
公开(公告)日：2011-05-25
申请号：EP10014374.2
申请日：2006-04-28
申请人： UCB Pharma S.A. , Amgen, Inc
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Popplewell, Andy , Shen, Wenyan , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：EP2295448A1
公开(公告)日：2011-03-16
申请号：EP10014372.6
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen, Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
摘要翻译： 本发明涉及硬骨素的多肽片段和结合该片段的抗体。 该抗体可用于治疗骨密度低的疾病，如骨质疏松症，以及加速骨折愈合。
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公开(公告)号：EP2264063A1
公开(公告)日：2010-12-22
申请号：EP10008795.6
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen, Inc
发明人： Paszty, Christopher , Robinson, Marty Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Popplewell, Andy , Shen, Wenyan , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与软骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：EP2251351A1
公开(公告)日：2010-11-17
申请号：EP10006930.1
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
摘要翻译： 本发明涉及结合片段的硬化蛋白的多肽片段和抗体。 该抗体可用于治疗低骨密度疾病，如骨质疏松症，以及加速骨折愈合。
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