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公开(公告)号：EP2301961B1
公开(公告)日：2017-02-22
申请号：EP10014373.4
申请日：2006-04-28
申请人： Amgen Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
摘要翻译： 本发明涉及硬骨素的多肽片段和结合该片段的抗体。 该抗体可用于治疗骨密度低的疾病，如骨质疏松症，以及加速骨折愈合。
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公开(公告)号：EP2336163A1
公开(公告)日：2011-06-22
申请号：EP10014375.9
申请日：2006-04-28
申请人： UCB Pharma S.A. , Amgen, Inc
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Popplewell, Andy , Shen, Wenyan , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：EP0297913B1
公开(公告)日：1995-02-15
申请号：EP88306039.4
申请日：1988-06-30
申请人： AMGEN INC.
发明人： Lin, Fu-Kuen , Lu, Hsieng Sen
CPC分类号： C12N9/6445 , A61K38/00 , C12N15/85 , C12N2830/00 , C12N2830/85 , C12Q1/6876 , G01N33/68
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公开(公告)号：EP3569620A1
公开(公告)日：2019-11-20
申请号：EP19181187.6
申请日：2009-12-18
申请人： Amgen Inc.
发明人： Boone, Thomas Charles , Brankow, David W. , Gegg Jr., Colin V. , Hu, Shaw-Fen Sylvia , King, Chadwick T. , Lu, Hsieng Sen , Shi, Licheng , Xu, Cen
IPC分类号： C07K16/28 , A61K39/395 , A61P25/06
摘要： Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
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公开(公告)号：EP2298800B1
公开(公告)日：2016-11-30
申请号：EP10014361.9
申请日：2006-04-28
申请人： Amgen Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
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公开(公告)号：EP2325199B1
公开(公告)日：2015-03-04
申请号：EP10014362.7
申请日：2006-04-28
申请人： AMGEN, INC.
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Winters, Aaron George , Winkler, David , Shen, Wenyan , Popplewell, Andy
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
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公开(公告)号：EP2336177A1
公开(公告)日：2011-06-22
申请号：EP10013141.6
申请日：2005-08-04
申请人： Amgen, Inc
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.
摘要翻译： 本发明提供特异性结合Dkk-1多肽的抗体及其免疫功能片段。 受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病，包括骨病，炎性疾病，神经疾病，眼病，肾病，肺部疾病和皮肤疾病。
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公开(公告)号：EP2345668A1
公开(公告)日：2011-07-20
申请号：EP10014360.1
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen, Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
摘要翻译： 本发明涉及结合片段的硬化蛋白的多肽片段和抗体。 该抗体可用于治疗低骨密度疾病，如骨质疏松症，以及加速骨折愈合。
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公开(公告)号：EP2298800A1
公开(公告)日：2011-03-23
申请号：EP10014361.9
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen, Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
摘要翻译： 本发明涉及结合片段的硬化蛋白的多肽片段和抗体。 该抗体可用于治疗低骨密度疾病，如骨质疏松症，以及加速骨折愈合。
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公开(公告)号：EP2295448B1
公开(公告)日：2017-01-18
申请号：EP10014372.6
申请日：2006-04-28
申请人： Amgen Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
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