公开(公告)号：EP1218360B1

公开(公告)日：2008-05-28

申请号：EP00972036.8

申请日：2000-10-06

申请人： Amgen Inc.,

发明人： ARMISTEAD, David, M. ,  BEMIS, Jean, E. ,  BUCHANAN, John, L. ,  DIPIETRO, Lucian, V. ,  ELBAUM, Daniel ,  HABGOOD, Gregory, J. ,  KIM, Joseph, L. ,  MARSHALL, Teresa, L. ,  GEUNS-MEYER, Stephanie, D. ,  NOVAK, Perry, M. ,  NUNES, Joseph, J. ,  PATEL, Vinod F. ,  TOLEDO-SHERMAN, Leticia, M. ,  ZHU, Xiaotian

IPC分类号： C07D251/22 ,  C07D403/12 ,  A61P43/00 ,  C07D251/16 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D405/04 ,  C07D401/14 ,  C07D405/14

CPC分类号： C07D401/04 ,  C07D251/18 ,  C07D251/22 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： The invention relates to inhibitors of formula (I) of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms. In formula (I), each R?1 and R2¿ is independently R?3; R8; NHR3; NHR5; NHR6; NR5R5; NR5R6; SR5; SR6; SR3; OR5; OR6; OR3; C(O)R3¿; heterocyclyl optionally substituted with 1-4 independent R4 on each ring; or C1-C10 alkyl substituted with 1-4 independent R?4; R3, R4, R5, R6, R8¿ are as defined in the application.

公开(公告)号：EP1562933B1

公开(公告)日：2008-03-19

申请号：EP03764755.9

申请日：2003-07-15

申请人： AMGEN INC.

发明人： PATEL, Vinod, F. ,  ASKEW JR, Benny, C. ,  BOOKER, Shon ,  CHEN, Guoqing ,  DIPIETRO, Lucian, V. ,  GERMAIN, Julie ,  HABGOOD, Gregory, J. ,  HUANG, Qi ,  KIM, Tae-Seong ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  RIAHI, Babak ,  YUAN, Chester, Chenguang ,  ELBAUM, Daniel

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D417/14 ,  C07D405/14 ,  C07D407/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4433 ,  C07D413/14

CPC分类号： C07D471/04 ,  A61K31/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1664027B1

公开(公告)日：2009-12-30

申请号：EP04782152.5

申请日：2004-08-25

申请人： AMGEN INC.

发明人： TEGLEY, Christopher ,  ADAMS, Jeffrey, A. ,  ASKEW, Benny, C., Jr. ,  CROGHAN, Michael ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  HABGOOD, Gregory, J. ,  HARRIED, Scott ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana Bogazici University ,  TASKER, Andrew ,  YANG, Kevin

IPC分类号： C07D401/12 ,  C07D401/14 ,  A61K31/4427 ,  A61K31/4035 ,  A61K31/47 ,  A61P29/00 ,  A61P35/00

CPC分类号： C04B35/632 ,  C07D401/12 ,  C07D401/14

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1664027A1

公开(公告)日：2006-06-07

申请号：EP04782152.5

申请日：2004-08-25

申请人： AMGEN INC.

发明人： TEGLEY, Christopher ,  ADAMS, Jeffrey, A. ,  ASKEW, Benny, C., Jr. ,  CROGHAN, Michael ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  HABGOOD, Gregory, J. ,  HARRIED, Scott ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana Bogazici University ,  TASKER, Andrew ,  YANG, Kevin

IPC分类号： C07D401/12 ,  C07D401/14 ,  A61K31/4427 ,  A61K31/4035 ,  A61K31/47 ,  A61P29/00 ,  A61P35/00

CPC分类号： C04B35/632 ,  C07D401/12 ,  C07D401/14

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1257546A1

公开(公告)日：2002-11-20

申请号：EP01909266.7

申请日：2001-02-16

申请人： Amgen Inc.

发明人： ARMISTEAD, David, M. ,  BEMIS, Jean, E. ,  DI PIETRO, Lucian, V. ,  GEUNS-MEYER, Stephanie, D. ,  HABGOOD, Gregory, J. ,  KIM, Joseph, L. ,  NUNES, Joseph, J. ,  PATEL, Vinod, F. ,  TOLEDO-SHERMAN, Leticia, M.

IPC分类号： C07D403/12 ,  C07D403/04 ,  C07D413/04 ,  C07D417/14 ,  C07D401/14 ,  C07D413/14 ,  A61K31/505

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

摘要： The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptoms.

公开(公告)号：EP1537084B1

公开(公告)日：2013-08-21

申请号：EP03764794.8

申请日：2003-07-15

申请人： AMGEN INC.

发明人： ASKEW JR, Benny C. ,  ADAMS, Jeffrey ,  BOOKER, Shon ,  CHEN, Guoqing ,  DIPIETRO, Lucian, V. ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  GEUNS-MEYER, Stephanie, D. ,  HABGOOD, Gregory, J. ,  HANDLEY, Michael ,  HUANG, Qi ,  KIM, Tae-Seong ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana, Bogazici University ,  PATEL, Vinod, F. ,  RIAHI, Babak ,  KIM, Joseph, L. ,  XI, Ning ,  YUAN, Chester, Chenguang

IPC分类号： C07D213/82 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/44 ,  A61P19/00 ,  A61P35/00

CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

公开(公告)号：EP1562933A2

公开(公告)日：2005-08-17

申请号：EP03764755.9

申请日：2003-07-15

申请人： Amgen Inc.

发明人： PATEL, Vinod, F. ,  ASKEW JR, Benny, C. ,  BOOKER, Shon ,  CHEN, Guoqing ,  DIPIETRO, Lucian, V. ,  GERMAIN, Julie ,  HABGOOD, Gregory, J. ,  HUANG, Qi ,  KIM, Tae-Seong ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  RIAHI, Babak ,  YUAN, Chester, Chenguang ,  ELBAUM, Daniel

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D417/14 ,  C07D405/14 ,  C07D407/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4433 ,  C07D413/14

CPC分类号： C07D471/04 ,  A61K31/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1537084A1

公开(公告)日：2005-06-08

申请号：EP03764794.8

申请日：2003-07-15

申请人： Amgen Inc.

发明人： ASKEW JR, Benny C. ,  ADAMS, Jeffrey ,  BOOKER, Shon ,  CHEN, Guoqing ,  DIPIETRO, Lucian, V. ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  GEUNS-MEYER, Stephanie, D. ,  HABGOOD, Gregory, J. ,  HANDLEY, Michael ,  HUANG, Qi ,  KIM, Tae-Seong ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  PATEL, Vinod, F. ,  RIAHI, Babak ,  KIM, Joseph, L. ,  XI, Ning ,  YUAN, Chester, Chenguang

IPC分类号： C07D213/82 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/44 ,  A61P19/00 ,  A61P35/00

CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected amines of Formula XIII, which are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 选择的式ⅩⅢ胺有效预防和治疗疾病，如血管生成介导的疾病。 本发明包括新化合物，类似物，前药和药学上可接受的盐，用于预防和治疗涉及癌症等的疾病和其他疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及用于这些方法的中间体。

公开(公告)号：EP1218360A1

公开(公告)日：2002-07-03

申请号：EP00972036.8

申请日：2000-10-06

申请人： Amgen Inc.,

发明人： ARMISTEAD, David, M. ,  BEMIS, Jean, E. ,  BUCHANAN, John, L. ,  DIPIETRO, Lucian, V. ,  ELBAUM, Daniel ,  HABGOOD, Gregory, J. ,  KIM, Joseph, L. ,  MARSHALL, Teresa, L. ,  GEUNS-MEYER, Stephanie, D. ,  NOVAK, Perry, M. ,  NUNES, Joseph, J. ,  PATEL, Vinod F. ,  TOLEDO-SHERMAN, Leticia, M. ,  ZHU, Xiaotian

IPC分类号： C07D251/22 ,  C07D403/12 ,  A61P43/00 ,  C07D251/16 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D405/04 ,  C07D401/14 ,  C07D405/14

CPC分类号： C07D401/04 ,  C07D251/18 ,  C07D251/22 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： The invention relates to inhibitors of formula (I) of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms. In formula (I), each R?1 and R2¿ is independently R?3; R8; NHR3; NHR5; NHR6; NR5R5; NR5R6; SR5; SR6; SR3; OR5; OR6; OR3; C(O)R3¿; heterocyclyl optionally substituted with 1-4 independent R4 on each ring; or C1-C10 alkyl substituted with 1-4 independent R?4; R3, R4, R5, R6, R8¿ are as defined in the application.