-
公开(公告)号：EP1240345A2
公开(公告)日：2002-09-18
申请号：EP00982518.3
申请日：2000-12-08
IPC分类号： C12N15/90 , A01K67/027
CPC分类号： A01K67/0275 , A01K2217/05 , A61K39/00 , A61K48/00 , C07K14/505 , C07K2319/00 , C12N15/85 , C12N15/86 , C12N2750/14143 , C12N2830/003 , C12N2830/006 , C12N2840/203
摘要： Methods for high level expression of genes in primates are disclosed. Such methods involve expression of transgenes comprising an RSV promoter and a nucleic acid sequence that is heterologous thereto.
-
2.发明公开MATERIALS AND METHODS INVOLVING CONDITIONAL AGGREGATION DOMAINS 审中-公开材料与方法条件AGGREAGATIONSDOMÄNENCONTAIN
公开(公告)号：EP1123405A1
公开(公告)日：2001-08-16
申请号：EP99955002.3
申请日：1999-10-19
发明人： CLACKSON, Timothy , RIVERA, Victor
IPC分类号： C12N15/62 , C12N15/12 , C12N15/86 , C07K14/47 , C07K14/62 , C07K14/485 , C12N5/10 , C12N9/90 , A01K67/027
CPC分类号： C07K14/62 , A01K2217/05 , C07K14/4702 , C07K14/48 , C07K14/485 , C07K2319/00 , C12N2799/021
摘要： This document discloses materials and methods involving conditional self-aggregation domains, including fusion proteins containing them, recombinant nucleic acids encoding such fusion proteins, genetically engineered cells containing such recombinant nucleic acids and uses thereof.
-
3.发明公开BIOMARKERS FOR EVALUATING LIKELIHOOD OF TUMOR SENSITIVITY TO AN MTOR INHIBITOR 审中-公开生物标志物评价中敏感性的肿瘤的的概率任何mTOR抑制剂
公开(公告)号：EP1899463A2
公开(公告)日：2008-03-19
申请号：EP06759344.2
申请日：2006-05-08
IPC分类号： C12N15/09
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N33/57484 , G01N2800/52
摘要： The present invention provides compositions and methods for evaluating the likelihood that a tumor is sensitive to an mTOR inhibitor, e.g., rapamycin or a rapamycin analog. The invention provides FKBP proteins as biomarkers for predicting the likelihood that a tumor is sensitive to an mTOR inhibitor. The methods include assessing the expression or activity of an FKBP protein, e.g., FKBP 12, in a subject with a tumor or in a sample derived from a tumor. Additional biomarkers and biomarker combinations are also provided. The invention also provides kits containing, e.g., a validated antibody or ligand for assessing the expression or activity of an FKBP protein.
-
公开(公告)号：EP1144655A3
公开(公告)日：2001-12-19
申请号：EP99955001.5
申请日：1999-10-19
-
公开(公告)号：EP1144655A2
公开(公告)日：2001-10-17
申请号：EP99955001.5
申请日：1999-10-19
CPC分类号： C07K14/62 , A01K2217/05 , C07K14/47 , C07K14/4702 , C07K14/811 , C07K2319/00 , C07K2319/03 , C07K2319/04 , C07K2319/09 , C07K2319/32 , C07K2319/50 , C07K2319/60 , C07K2319/71 , C07K2319/715 , C07K2319/75 , C07K2319/81 , C12N15/625 , C12N2799/022
摘要： Materials and methods involving conditional retention domains (CRDs) are disclosed. A conditional retention domain is any domain which is retained in the ER or other secretory compartment in the absence of ligand and is released from the secretory machinery when ligand is bound, i.e. in the presence of ligand. Also disclosed are fusion proteins containing CRDs and cells expressing such fusion proteins. In addition, the invention provides novel methods for producing target proteins in vivo using fusion proteins containing conditional retention domains and methods for identifying novel CRDs.
-
公开(公告)号：EP1078096A1
公开(公告)日：2001-02-28
申请号：EP99922872.9
申请日：1999-05-10
发明人： WILSON, James , RIVERA, Victor , GILMAN, Michael , YE, Xuehai
CPC分类号： C12N15/86 , C12N2710/10344 , C12N2750/14143 , C12N2830/00 , C12N2830/42 , C12N2830/85 , C12N2840/203
摘要： The invention provides improved compositions and methods for using them in gene therapy.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.018 秒)
