公开(公告)号：EP1439897A4

公开(公告)日：2006-03-08

申请号：EP02801051

申请日：2002-10-10

申请人： AVIVA BIOSCIENCES CORP

发明人： YAMANISHI DOUGLAS ,  HUJSAK PAUL ,  YANG ZHAOHUAI ,  XU JUNQUAN ,  WANG XIAOBO ,  WU LEI ,  HUANG MINGXIAN ,  TAO GUOLIANG ,  CHENG JING

IPC分类号： A61M1/36 ,  C12N5/00 ,  C12N5/06 ,  C12N5/08 ,  G01N1/40 ,  G01N15/02 ,  G01N15/05 ,  G01N15/06 ,  B01D57/02

CPC分类号： G01N15/05 ,  A61M1/36 ,  A61M1/3618 ,  A61M1/362 ,  A61M1/3679 ,  G01N1/40 ,  G01N15/0272 ,  G01N33/491 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2015/0681

摘要： The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells from a complex fluid sample. In particular, the enrichment of fetal cells from maternal samples, such as maternal blood samples, can greatly aid in the detection of fetal abnormalities or a variety of genetic conditions. In addition, the present invention recognizes that the enrichment of rare malignant cells from patient samples, can aid in diagnosis, prognosis, and development of therapeutic modalities for patients.

摘要翻译： 本发明认识到并的许多条件的诊断和预后可以取决于从复杂流体样品稀有细胞的富集。 特别是，胎儿细胞从母体样品，颜色的富集：如母体血液样品中，可以在检测胎儿畸形或多种遗传条件极大地帮助。 此外，本发明认识到确实少见恶性细胞的富集的患者样品可以在诊断，预后和为患者治疗方法的发展。

公开(公告)号：EP1694856A4

公开(公告)日：2008-09-10

申请号：EP04784274

申请日：2004-09-15

申请人： AVIVA BIOSCIENCES CORP

发明人： WALKER GEORGE ,  XU JUNQUAN ,  YAMANISHI DOUGLAS ,  HUJSAK PAUL ,  WU LEI ,  HUANG MINGXIAN ,  TAO GUOLIANG ,  SNYDER SARA ,  YAP CHARINA

IPC分类号： C12Q1/02 ,  A61M1/36 ,  B01D57/02 ,  B01D61/18 ,  B01D67/00 ,  B01D71/02 ,  B01D71/04 ,  B01L3/00 ,  C12N5/00 ,  C12N5/06 ,  C12N5/08 ,  G01N1/34 ,  G01N1/40 ,  G01N15/00 ,  G01N15/02 ,  G01N15/05 ,  G01N15/06

CPC分类号： B01L3/502761 ,  A61M1/36 ,  A61M1/3618 ,  A61M1/362 ,  A61M1/3679 ,  B01D57/02 ,  B01D61/18 ,  B01D67/0034 ,  B01D67/0062 ,  B01D71/02 ,  B01D71/027 ,  B01D71/04 ,  B01D2325/021 ,  B01D2325/04 ,  B01L3/502 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/0409 ,  B01L2400/0457 ,  B01L2400/0478 ,  B01L2400/0644 ,  B01L2400/065 ,  G01N1/40 ,  G01N15/0272 ,  G01N15/05 ,  G01N2001/4016 ,  G01N2015/0073 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2015/0681

摘要： The invention includes microfabricated filters for filtering fluid samples and methods of enriching rare cells of fluid samples using microfabricated filters of the present invention. The invention also includes solutions for the selective sedimentation of red blood cells (RBCs) from a blood sample and methods of using selective RBC sedimentation solutions for enriching rare cells of a fluid sample. Yet another aspect of the invention is an automated system for processing a fluid sample that includes: at least one filtration chamber that includes a microfabricated filter; automated means for directing fluid flow through at least one filtration chamber of the automated system, and means for collecting enriched rare cells. The present invention also includes methods of using automated systems for separating rare cells from fluid samples.