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1.发明授权AMINOINDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权AMINOINDANDERIVATE，药物组合物阶及其治疗用途
公开(公告)号：EP2603481B1
公开(公告)日：2014-09-17
申请号：EP11757790.8
申请日：2011-08-12
发明人： LANGE, Udo , AMBERG, Wilhelm , OCHSE, Michael , POHLKI, Frauke , BEHL, Berthold , HUTCHINS, Charles
IPC分类号： C07C11/10 , C07C311/14 , C07D205/04 , C07D231/18 , C07D233/84 , A61K31/397 , A61K31/415 , A61K31/4164 , A61K31/18 , A61P25/18 , A61P25/22 , A61P25/24
CPC分类号： C07C311/14 , C07C311/10 , C07C2601/02 , C07C2602/08 , C07D205/04 , C07D231/18 , C07D233/84 , C07D403/12
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2.发明公开AMINOINDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权AMINOINDANDERIVATE，药剂师ZUSAMMENSETZUNGEN DAMIT UND IHRE THERAPEUTISCHE VERWENDUNG
公开(公告)号：EP2603481A2
公开(公告)日：2013-06-19
申请号：EP11757790.8
申请日：2011-08-12
发明人： LANGE, Udo , AMBERG, Wilhelm , OCHSE, Michael , POHLKI, Frauke , BEHL, Berthold , HUTCHINS, Charles
IPC分类号： C07C11/10 , C07C311/14 , C07D205/04 , C07D231/18 , C07D233/84 , A61K31/397 , A61K31/415 , A61K31/4164 , A61K31/18 , A61P25/18 , A61P25/22 , A61P25/24
CPC分类号： C07C311/14 , C07C311/10 , C07C2601/02 , C07C2602/08 , C07D205/04 , C07D231/18 , C07D233/84 , C07D403/12
摘要： The present invention relates to aminoindane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminoindane derivatives, and the use of such aminoindane derivatives for therapeutic purposes. The aminoindane derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I）的氨基茚满衍生物或其生理上耐受的盐。 本发明涉及包含这种氨基茚满衍生物的药物组合物，以及这种氨基茚满衍生物用于治疗目的的用途。 氨基茚满衍生物是GlyT1抑制剂。
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3.发明公开AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权AMINOTETRALINDERIVATE，PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DAMIT UND IHRE THERAPEUTISCHE VERWENDUNG
公开(公告)号：EP2396296A1
公开(公告)日：2011-12-21
申请号：EP10706575.7
申请日：2010-02-16
发明人： AMBERG, Wilhelm , OCHSE, Michael , LANGE, Udo , KLING, Andreas , BEHL, Berthold , HORNBERGER, Wilfried , MEZLER, Mario , HUTCHINS, Charles
IPC分类号： C07C215/70 , C07C311/00 , C07C317/00 , C07C233/00 , C07D213/71 , C07D231/18 , C07D233/84 , C07D249/12 , C07D261/08 , C07D275/02 , C07D305/08 , C07D333/04 , C07F7/10 , A61K31/16 , A61P25/00
CPC分类号： C07C311/05 , C07C215/64 , C07C217/74 , C07C233/18 , C07C233/19 , C07C233/69 , C07C255/58 , C07C271/24 , C07C307/06 , C07C309/65 , C07C311/07 , C07C311/09 , C07C311/10 , C07C311/13 , C07C311/14 , C07C311/17 , C07C311/18 , C07C311/20 , C07C311/24 , C07C317/18 , C07C317/28 , C07C2601/02 , C07C2601/04 , C07C2602/10 , C07D205/04 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/27 , C07D207/36 , C07D207/48 , C07D213/71 , C07D231/18 , C07D233/84 , C07D249/12 , C07D261/08 , C07D265/30 , C07D275/02 , C07D295/096 , C07D295/135 , C07D305/08 , C07D333/34 , C07D401/12 , C07D403/12 , C07D409/12 , C07F7/0818
摘要： The present invention relates to aminotetraline derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminotetraline derivatives, and the use of such aminotetraline derivatives for therapeutic purposes. The aminotetraline derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I）的氨基四氢化萘衍生物或其生理上耐受的盐。 本发明涉及包含这种氨基四氢化萘衍生物的药物组合物以及这种氨基四氢化萘衍生物用于治疗目的的用途。 氨基四氢叶酸衍生物是GlyT1抑制剂。
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4.发明公开PHENALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开表鬼臼毒胺衍生物，含有它们的药物组合物及其在治疗中的用途
公开(公告)号：EP2603487A1
公开(公告)日：2013-06-19
申请号：EP11748621.7
申请日：2011-08-12
申请人： Abbott GmbH & Co. KG , AbbVie Inc.
发明人： AMBERG, Wilhelm , OCHSE, Michael , LANGE, Udo , BEHL, Berthold , HORNBERGER, Wilfried , MEZLER, Mario , POHLKI, Frauke , TURNER, Sean , HUTCHINS, Charles
IPC分类号： C07C311/04 , C07C311/05 , C07C311/10 , C07D205/04 , C07D207/08 , C07D211/22 , C07D231/18 , C07D233/84 , C07D207/267 , C07D295/03 , A61K31/18 , A61K31/415 , A61K31/4164 , A61P25/28 , A61P25/18
CPC分类号： C07C311/06 , C07C311/04 , C07C311/05 , C07C311/10 , C07C2601/02 , C07C2601/04 , C07D205/04 , C07D207/08 , C07D207/267 , C07D231/18 , C07D233/42 , C07D233/84 , C07D295/135 , C07D401/12 , C07D403/12
摘要： The present invention relates to phenalkylamine derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such phenalkylamine derivatives, and the use of such phenalkylamine derivatives for therapeutic purposes. The phenalkylamine derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I）的苯烷基胺衍生物或其生理学耐受的盐。 本发明涉及包含这种苯烷基胺衍生物的药物组合物，以及这种苯烷基胺衍生物用于治疗目的的用途。 苯烷基胺衍生物是GlyT1抑制剂。
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5.发明公开TETRALINE AND INDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开TETRALIN- UND INDANDERIVATE，PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DAMIT UND IHRE THERAPEUTISCHE VERWENDUNG
公开(公告)号：EP2709987A1
公开(公告)日：2014-03-26
申请号：EP11749147.2
申请日：2011-08-12
申请人： Abbott GmbH & Co. KG , AbbVie Inc.
发明人： LANGE, Udo , AMBERG, Wilhelm , OCHSE, Michael , BEHL, Berthold , POHLKI, Frauke , HUTCHINS, Charles
IPC分类号： C07D233/84 , C07C311/03 , A61K31/4164 , A61K31/18 , A61P29/00 , A61P25/00
CPC分类号： C07D233/84 , C07C311/05 , C07C311/10 , C07C311/14 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/08 , C07C2602/10
摘要： The present invention relates to tetraline and indane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such tetraline and indane derivatives, and the use of such tetraline and indane derivatives for therapeutic purposes. The tetraline and indane derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I）的四氢化萘和二氢化茚衍生物或其生理上耐受的盐。 本发明涉及包含这种四氢化萘和二氢化茚衍生物的药物组合物，以及这种四氢化萘和二氢化茚衍生物用于治疗目的的用途。 四氢萘并茚满衍生物是GlyT1抑制剂。
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6.发明公开PHENALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开PHENALKYLAMINDERIVATE，药物组合物阶及其治疗用途
公开(公告)号：EP2603493A1
公开(公告)日：2013-06-19
申请号：EP11749148.0
申请日：2011-08-12
申请人： Abbott GmbH & Co. KG , AbbVie Inc.
发明人： POHLKI, Frauke , AMBERG, Wilhelm , LANGE, Udo , OCHSE, Michael , BEHL, Berthold , HORNBERGER, Wilfried , MEZLER, Mario , HUTCHINS, Charles
IPC分类号： C07D217/02 , C07D401/12 , A61K31/472 , A61K31/4725 , A61P25/18
CPC分类号： C07D401/12 , A61K31/357 , A61K31/472 , A61K31/4725 , A61K31/538 , C07D217/02 , C07D217/08 , C07D217/22 , C07D217/26
摘要： The present invention relates to phenalkylamine derivatives of the formula (I) or (II); or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such phenalkylamine derivatives, and the use of such phenalkylamine derivatives for therapeutic purposes. The phenalkylamine derivatives are GlyT1 inhibitors.
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7.发明公开3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开3-（苯基烷氧基）-5-（苯基）一种癌的治疗作为激酶抑制剂的吡啶衍生物和相关化合物
公开(公告)号：EP1463505A2
公开(公告)日：2004-10-06
申请号：EP02790126.3
申请日：2002-12-12
申请人： Abbott Laboratories
发明人： LI, Qun , WOODS, Keith W. , ZHU, Gui-Dong , FISCHER, John P. , GONG, Jianchun , LI, Tongmei , GANDHI, Viraj , THOMAS, Sheela, A. , PACKARD, Garrick , SONG, Xiaohong , ABRAMS, Jason, N. , DIEBOLD, Robert , DINGES, Jurgen , HUTCHINS, Charles , STOLL, Vincent, S. , ROSENBERG, Saul, H. , GIRANDA, Vincent, L.
IPC分类号： A61K31/4439 , A61K31/444 , C07D401/12 , C07D401/14 , C07D401/04 , C07D475/02 , C07D213/63
摘要： Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
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