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1.发明公开PHENALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开表鬼臼毒胺衍生物，含有它们的药物组合物及其在治疗中的用途
公开(公告)号：EP2603487A1
公开(公告)日：2013-06-19
申请号：EP11748621.7
申请日：2011-08-12
申请人： Abbott GmbH & Co. KG , AbbVie Inc.
发明人： AMBERG, Wilhelm , OCHSE, Michael , LANGE, Udo , BEHL, Berthold , HORNBERGER, Wilfried , MEZLER, Mario , POHLKI, Frauke , TURNER, Sean , HUTCHINS, Charles
IPC分类号： C07C311/04 , C07C311/05 , C07C311/10 , C07D205/04 , C07D207/08 , C07D211/22 , C07D231/18 , C07D233/84 , C07D207/267 , C07D295/03 , A61K31/18 , A61K31/415 , A61K31/4164 , A61P25/28 , A61P25/18
CPC分类号： C07C311/06 , C07C311/04 , C07C311/05 , C07C311/10 , C07C2601/02 , C07C2601/04 , C07D205/04 , C07D207/08 , C07D207/267 , C07D231/18 , C07D233/42 , C07D233/84 , C07D295/135 , C07D401/12 , C07D403/12
摘要： The present invention relates to phenalkylamine derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such phenalkylamine derivatives, and the use of such phenalkylamine derivatives for therapeutic purposes. The phenalkylamine derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I）的苯烷基胺衍生物或其生理学耐受的盐。 本发明涉及包含这种苯烷基胺衍生物的药物组合物，以及这种苯烷基胺衍生物用于治疗目的的用途。 苯烷基胺衍生物是GlyT1抑制剂。
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2.发明公开TETRALINE AND INDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开TETRALIN- UND INDANDERIVATE，PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DAMIT UND IHRE THERAPEUTISCHE VERWENDUNG
公开(公告)号：EP2709987A1
公开(公告)日：2014-03-26
申请号：EP11749147.2
申请日：2011-08-12
申请人： Abbott GmbH & Co. KG , AbbVie Inc.
发明人： LANGE, Udo , AMBERG, Wilhelm , OCHSE, Michael , BEHL, Berthold , POHLKI, Frauke , HUTCHINS, Charles
IPC分类号： C07D233/84 , C07C311/03 , A61K31/4164 , A61K31/18 , A61P29/00 , A61P25/00
CPC分类号： C07D233/84 , C07C311/05 , C07C311/10 , C07C311/14 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/08 , C07C2602/10
摘要： The present invention relates to tetraline and indane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such tetraline and indane derivatives, and the use of such tetraline and indane derivatives for therapeutic purposes. The tetraline and indane derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I）的四氢化萘和二氢化茚衍生物或其生理上耐受的盐。 本发明涉及包含这种四氢化萘和二氢化茚衍生物的药物组合物，以及这种四氢化萘和二氢化茚衍生物用于治疗目的的用途。 四氢萘并茚满衍生物是GlyT1抑制剂。
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3.发明公开PHENALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开PHENALKYLAMINDERIVATE，药物组合物阶及其治疗用途
公开(公告)号：EP2603493A1
公开(公告)日：2013-06-19
申请号：EP11749148.0
申请日：2011-08-12
申请人： Abbott GmbH & Co. KG , AbbVie Inc.
发明人： POHLKI, Frauke , AMBERG, Wilhelm , LANGE, Udo , OCHSE, Michael , BEHL, Berthold , HORNBERGER, Wilfried , MEZLER, Mario , HUTCHINS, Charles
IPC分类号： C07D217/02 , C07D401/12 , A61K31/472 , A61K31/4725 , A61P25/18
CPC分类号： C07D401/12 , A61K31/357 , A61K31/472 , A61K31/4725 , A61K31/538 , C07D217/02 , C07D217/08 , C07D217/22 , C07D217/26
摘要： The present invention relates to phenalkylamine derivatives of the formula (I) or (II); or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such phenalkylamine derivatives, and the use of such phenalkylamine derivatives for therapeutic purposes. The phenalkylamine derivatives are GlyT1 inhibitors.
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4.发明公开4-BENZYLAMINOQUINOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE 审中-公开4- BENZYLAMINOCHINOLINE，药物组合物含有，其使用
公开(公告)号：EP2178842A2
公开(公告)日：2010-04-28
申请号：EP08787409.5
申请日：2008-08-22
申请人： Abbott GmbH & Co. KG
发明人： AMBERG, Wilhelm , OCHSE, Michael , BRAJE, Wilfried , BEHL, Berthold , HORNBERGER, Wilfried , MEZLER, Mario , HUTCHINS, Charles W.
IPC分类号： C07D215/42 , C07D215/46 , C07D401/04 , C07D401/12 , C07D401/14 , A61K31/4706 , A61K31/4709 , A61P25/00
CPC分类号： C07D215/42 , C07D215/46 , C07D401/12 , C07D401/14
摘要： The present invention relates to 4-benzylaminoquinolines of the formula (I) or physiologically tolerated salts thereof. The invention relates to pharmaceutical compositions comprising such quinolines, and the use of such quinolines for therapeutic purposes. The quinolines are GIyTI inhibitors.
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5.发明公开BICYCLISCHE LACTAME UND SULFONAMIDE MIT 5-HT1A-AFFINITÄT UND IHRE VERWENDUNG ZUR PROPHYLAXE UND THERAPIE DER ZEREBRALEN ISCHÄMIE 审中-公开双环内酰胺和磺酰胺，并用5-HT 1A亲和力和它们用于脑缺血的预防和治疗
公开(公告)号：EP1296954A1
公开(公告)日：2003-04-02
申请号：EP01954000.4
申请日：2001-07-02
申请人： Abbott GmbH & Co. KG
发明人： STEINER, Gerd , SCHELLHAAS, Kurt , SZABO, Laszlo , BEHL, Berthold , GARCIA-LADONA, Francisco, Javier , UNGER, Liliane
IPC分类号： C07D217/24 , A61K31/496 , A61P9/10 , C07D417/12 , C07D401/12 , C07D209/34 , C07D275/06 , C07D417/06 , C07D413/12 , A61K31/538 , A61K31/5415 , A61K31/553 , A61K31/554
CPC分类号： C07D275/06 , C07D209/34 , C07D217/24 , C07D401/12 , C07D413/12 , C07D417/06 , C07D417/12
摘要： Compounds of formula (I), wherein the ring with the increment (N-A) can be 5, 6 or 7-membered and can also contain an oxygen or sulfur atom or a C-C double bond, with the exception of the 1,4-benzoxazepine skeleton, A represents a carbonyl or sulfonyl group, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z is a nitrogen atom, a carbon atom or CH and the bond between Y and Z can also be a double bond, n means the number 2, 3 or 4, R1 can be a hydrogen atom, halogen or a C¿1?-C4-alkyl, trifluoromethyl, hydroxy, C1-C4-alkoxy or amino group and R?2¿ represents a phenyl, pyridyl or pyrazinyl group which is optionally mono or di-substituted by C¿1?-C4-alkyl, trifluoromethyl, trifluoromethoxy, hydroxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which can be anellated with a benzole nucleus which can be mono or di-substituted by halogen atoms, C1-C4-alkyl, hydroxy, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups and can optionally contain 1 nitrogen atom, or with a 5 or 6-membered ring which can contain 1 to 2 oxygen atoms; and physiologically compatible salts of these compounds show affinity for the 5-HT1A receptor and are suitable for treating cerebral ischaemia.
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6.发明授权AMINOINDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权AMINOINDANDERIVATE，药物组合物阶及其治疗用途
公开(公告)号：EP2603481B1
公开(公告)日：2014-09-17
申请号：EP11757790.8
申请日：2011-08-12
发明人： LANGE, Udo , AMBERG, Wilhelm , OCHSE, Michael , POHLKI, Frauke , BEHL, Berthold , HUTCHINS, Charles
IPC分类号： C07C11/10 , C07C311/14 , C07D205/04 , C07D231/18 , C07D233/84 , A61K31/397 , A61K31/415 , A61K31/4164 , A61K31/18 , A61P25/18 , A61P25/22 , A61P25/24
CPC分类号： C07C311/14 , C07C311/10 , C07C2601/02 , C07C2602/08 , C07D205/04 , C07D231/18 , C07D233/84 , C07D403/12
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7.发明授权
公开(公告)号：EP2271625B1
公开(公告)日：2012-09-12
申请号：EP09727055.7
申请日：2009-03-31
发明人： AMBERG, Wilhelm , OCHSE, Michael , LANGE, Udo , BRAJE, Wilfried , BEHL, Berthold , HORNBERGER, Wilfried , MEZLER, Mario , HUTCHINS, Charles W.
IPC分类号： C07D217/18 , C07D401/06 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D498/04 , C07D513/04 , A61K31/472 , A61P25/28
CPC分类号： C07D217/18 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07D513/04
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8.发明公开
公开(公告)号：EP2396323A1
公开(公告)日：2011-12-21
申请号：EP10704812.6
申请日：2010-02-16
申请人： Abbott GmbH & Co. KG
发明人： LANGE, Udo , HEUTLING, Andreas , AMBERG, Wilhelm , OCHSE, Michael , BEHL, Berthold , HORNBERGER, Wilfried , MEZLER, Mario
IPC分类号： C07D471/04 , C07D471/14 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/4355 , A61K31/4375 , A61P25/24
CPC分类号： C07D471/04 , C07D471/14 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention relates to heterocyclic compounds of the formula (I) or a physiologically tolerated salt thereof. The present invention also relates to pharmaceutical compositions comprising such heterocyclic compounds, and the use of such heterocyclic compounds for the manufacture of a medicament for inhibiting the glycine transporter GIyT1.
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9.发明公开
公开(公告)号：EP2271625A2
公开(公告)日：2011-01-12
申请号：EP09727055.7
申请日：2009-03-31
发明人： AMBERG, Wilhelm , OCHSE, Michael , LANGE, Udo , BRAJE, Wilfried , BEHL, Berthold , HORNBERGER, Wilfried , MEZLER, Mario , HUTCHINS, Charles W.
IPC分类号： C07D217/18 , C07D401/06 , C07D401/12 , C07D409/14 , C07D413/12 , C07D498/04 , C07D513/04 , A61K31/472 , A61P25/28
CPC分类号： C07D217/18 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07D513/04
摘要： The present invention relates to tetrahydroisoquinoline of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such tetrahydroisoquinolines, and the use of such tetrahydroisoquinolines for therapeutic purposes. The tetrahydroisoquinolines are GIyT1 inhibitors.
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10.发明公开AMINOINDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权AMINOINDANDERIVATE，药剂师ZUSAMMENSETZUNGEN DAMIT UND IHRE THERAPEUTISCHE VERWENDUNG
公开(公告)号：EP2603481A2
公开(公告)日：2013-06-19
申请号：EP11757790.8
申请日：2011-08-12
发明人： LANGE, Udo , AMBERG, Wilhelm , OCHSE, Michael , POHLKI, Frauke , BEHL, Berthold , HUTCHINS, Charles
IPC分类号： C07C11/10 , C07C311/14 , C07D205/04 , C07D231/18 , C07D233/84 , A61K31/397 , A61K31/415 , A61K31/4164 , A61K31/18 , A61P25/18 , A61P25/22 , A61P25/24
CPC分类号： C07C311/14 , C07C311/10 , C07C2601/02 , C07C2602/08 , C07D205/04 , C07D231/18 , C07D233/84 , C07D403/12
摘要： The present invention relates to aminoindane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminoindane derivatives, and the use of such aminoindane derivatives for therapeutic purposes. The aminoindane derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I）的氨基茚满衍生物或其生理上耐受的盐。 本发明涉及包含这种氨基茚满衍生物的药物组合物，以及这种氨基茚满衍生物用于治疗目的的用途。 氨基茚满衍生物是GlyT1抑制剂。
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