公开(公告)号：EP2263738A3

公开(公告)日：2011-11-09

申请号：EP10182893.7

申请日：2005-07-18

Applicant: Acclarent, Inc.

Inventor： Makower, Joshua ,  Chang, John Y ,  Vrany, Julia D ,  Walke, Amrish, Jayprakash

IPC: A61M29/00 ,  A61K9/22 ,  A61B19/00 ,  A61M25/10 ,  A61F5/08 ,  A61B17/24 ,  A61B5/06 ,  A61B17/16 ,  A61B1/00

CPC classification number: A61M31/002 ,  A61B5/06 ,  A61B5/064 ,  A61B5/411 ,  A61B17/24 ,  A61B17/320725 ,  A61B17/320758 ,  A61B17/320783 ,  A61B17/3478 ,  A61B34/20 ,  A61B2017/22061 ,  A61F2/18 ,  A61F2/82 ,  A61F2002/825 ,  A61F2250/0039 ,  A61M25/0029 ,  A61M25/007 ,  A61M25/10 ,  A61M2025/0037 ,  A61M2025/105 ,  A61M2025/1052

Abstract: Implantable devices for delivering drugs and other substances to locations within the body of a human or animal subject to treat or diagnose sinusitis and a variety of other disorders. The application includes implantable substance delivery devices that comprise reservoirs and barriers that control the rate at which substances pass out of the reservoirs. The delivery devices may be advanced into the body using guidewires, catheters, ports, introducers and other access apparatus. In some embodiments the delivery devices may be loaded with one or more desired substance before their introduction into the body. In other embodiments the delivery devices are loaded and/or reloaded with a desired substance after the delivery device has been introduced into the body.

公开(公告)号：EP2662109B1

公开(公告)日：2015-04-15

申请号：EP13179223.6

申请日：2005-09-14

Applicant: Acclarent, Inc.

Inventor： Chang, John Y. ,  Makower, Joshua ,  Vrany, Julia D. ,  Walke, Amrish, Jayprakash

IPC: A61M29/00 ,  A61M25/10 ,  A61B17/24

CPC classification number: A61M29/02 ,  A61B5/6852 ,  A61B17/24 ,  A61B17/32002 ,  A61B17/3403 ,  A61B17/3421 ,  A61B18/1492 ,  A61B2017/22039 ,  A61B2017/22051 ,  A61B2017/22061 ,  A61B2018/00327 ,  A61B2018/00595 ,  A61B2034/2051 ,  A61F2/186 ,  A61F2/82 ,  A61F2/90 ,  A61F2/95 ,  A61F2/958 ,  A61M25/0026 ,  A61M25/005 ,  A61M25/0082 ,  A61M25/0102 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/09 ,  A61M25/10 ,  A61M25/1006 ,  A61M25/1011 ,  A61M2025/0177 ,  A61M2025/1072 ,  A61M2025/1079 ,  A61M2025/109 ,  A61M2029/025 ,  A61M2210/0681 ,  A61M2210/1028

Abstract: A guide catheter (200) has a pre-set shape for insertion into a nasal cavity. Said guide catheter (200) comprises a proximal end, a distal end, and a lumen extending from the proximal end to the distal end. Said guide catheter (200) incorporates one or more preformed curves or bends, wherein the curved or bent regions form a deflection angle selected from: 30 degrees, 45 degrees, 60 degrees, 70 degrees, 90 degrees, 120 degrees and 135 degrees. A system for diagnosing and/or treating sinusitis or another disorder affecting the nose, paranasal sinuses or other anatomical structures of the ear, nose or throat comprises: a guide catheter (200) as described above; a balloon catheter (204) that can be advanced along the guide catheter (200), wherein the balloon catheter (204) comprises an inflatable balloon; and optionally a guidewire (202) that can be inserted through the lumen of the guide catheter (200).

公开(公告)号：EP2532383A3

公开(公告)日：2013-01-02

申请号：EP12182993.1

申请日：2006-01-18

Applicant: Acclarent, Inc.

Inventor： Chang, John Y. ,  Makower, Joshua ,  Vrany, Julia D. ,  Lamson, Theodore, C. ,  Walke, Amrish, Jayprakash

IPC: A61M25/10 ,  A61M29/02

CPC classification number: A61B1/00154 ,  A61B1/233 ,  A61B5/062 ,  A61B5/745 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/24 ,  A61B18/24 ,  A61B50/13 ,  A61B50/15 ,  A61B50/20 ,  A61F11/00 ,  A61F11/002 ,  A61M25/0041 ,  A61M25/1002 ,  A61M25/1011 ,  A61M29/02 ,  A61M2025/0226 ,  A61M2025/0681 ,  A61M2025/09116 ,  A61M2025/09175 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2210/0675 ,  A61N7/022

Abstract: A catheter device (1000) for treating a disease or disorder of a paranasal sinus having an ostium which opens into said paranasal sinus, said device comprising: a catheter shaft (1002) having a distal end, said catheter shaft being suitable for advancing, distal end first, through the ostium and into the paranasal sinus; a distal balloon (1006) for positioning inside the paranasal sinus adjacent to the ostium; a proximal balloon (1004) for positioning outside the paranasal sinus adjacent to the ostium; and at least one balloon inflation lumen extending through the catheter shaft (1002) for inflation of said distal and proximal balloons (1006,1004), said device further comprising a lumen that is sized to receive a guidewire such that the device may be advanced over a guidewire.

Abstract translation: 一种用于将物质输送到人或动物受试者的鼻旁窦的口腔的气囊导管装置（1400），所述装置包括：导管轴（1402），具有球囊膨胀腔; 附接到导管轴（1402）并与所述球囊充气腔（1410）流体连通的气囊（1404）; 并且其特征在于，所述装置还包括附接到导管轴（1402）并围绕球囊的多孔外护套（1406），所述导管轴（1402）中的药剂输送腔（1412）与所述导管轴 球囊（1404）和多孔护套（1406），所述球囊可充气以将所述多孔外护套（1406）压缩在所述鼻旁口内的组织上，由此通过所述药剂输送腔引入的治疗有效量的物质可穿过多孔 外鞘并与鼻旁口接触。

公开(公告)号：EP2258440A2

公开(公告)日：2010-12-08

申请号：EP10182961.2

申请日：2005-07-18

Applicant: Acclarent, Inc.

Inventor： Chang, John Y ,  Makower, Joshua ,  Vrany, Julia D ,  Walke, Amrish, Jayprakash

IPC: A61M29/00 ,  A61K9/22 ,  A61B19/00

CPC classification number: A61M31/002 ,  A61B5/06 ,  A61B5/064 ,  A61B5/411 ,  A61B17/24 ,  A61B17/320725 ,  A61B17/320758 ,  A61B17/320783 ,  A61B17/3478 ,  A61B34/20 ,  A61B2017/22061 ,  A61F2/18 ,  A61F2/82 ,  A61F2002/825 ,  A61F2250/0039 ,  A61M25/0029 ,  A61M25/007 ,  A61M25/10 ,  A61M2025/0037 ,  A61M2025/105 ,  A61M2025/1052

Abstract: A system comprising a guide a, balloon catheter (200) and an inflator. The balloon (202) can be inflated to a size and pressure to cause breakage of bone and the enlargement of a passageway leading to a paranasal sinus.

Abstract translation: 一种包括引导件a，气囊导管（200）和充气器的系统。 气球（202）可以膨胀到一定的尺寸和压力，从而导致骨折断裂和通向鼻旁窦的通道的扩大。

公开(公告)号：EP2959865A1

公开(公告)日：2015-12-30

申请号：EP15163549.7

申请日：2005-09-14

Applicant: Acclarent, Inc.

Inventor： Chang, John Y. ,  Makower, Joshua ,  Vrany, Julia D. ,  Walke, Amrish, Jayprakash

IPC: A61F2/18 ,  A61B5/00 ,  A61B17/24 ,  A61B17/32 ,  A61F2/82 ,  A61F2/90 ,  A61B17/34 ,  A61F2/95 ,  A61M25/00 ,  A61M25/01 ,  A61M25/09 ,  A61M25/10 ,  A61F2/958 ,  A61B18/14 ,  A61M29/02 ,  A61B17/22 ,  A61B18/00 ,  A61B19/00

CPC classification number: A61M29/02 ,  A61B5/6852 ,  A61B17/24 ,  A61B17/32002 ,  A61B17/3403 ,  A61B17/3421 ,  A61B18/1492 ,  A61B2017/22039 ,  A61B2017/22051 ,  A61B2017/22061 ,  A61B2018/00327 ,  A61B2018/00595 ,  A61B2034/2051 ,  A61F2/186 ,  A61F2/82 ,  A61F2/90 ,  A61F2/95 ,  A61F2/958 ,  A61M25/0026 ,  A61M25/005 ,  A61M25/0082 ,  A61M25/0102 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/09 ,  A61M25/10 ,  A61M25/1006 ,  A61M25/1011 ,  A61M2025/0177 ,  A61M2025/1072 ,  A61M2025/1079 ,  A61M2025/109 ,  A61M2029/025 ,  A61M2210/0681 ,  A61M2210/1028

Abstract: Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodelling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices may be used, comprising a introducing member having a proximal end and a distal end for insertion into in a nasal cavity; and a working device that can be advanced along the introducing member, wherein the working device comprises a balloon catheter comprises radiographic markers.

Abstract translation: 鼻窦炎和耳，鼻，喉的其它病症被诊断和/或使用具有柔性或刚性的乐器微创治疗途径。 各种方法和装置用于重塑或改变在耳，鼻或咽喉鼻窦口或导管或其他解剖结构的形状，尺寸或构型; 植入装置，细胞或组织; 从耳，鼻或喉咙移除事宜; 递送诊断或治疗物质或进行其它诊断或治疗过程。 引入装置可以被使用，包括：具有近端和远端用于插入到鼻腔中一个导入部件; 和工作装置都可以沿着导入部件worin工作设备包括球囊导管包括射线照相标记前进。

公开(公告)号：EP2258440B1

公开(公告)日：2014-08-20

申请号：EP10182961.2

申请日：2005-07-18

Applicant: Acclarent, Inc.

Inventor： Chang, John Y ,  Makower, Joshua ,  Vrany, Julia D ,  Walke, Amrish, Jayprakash

IPC: A61F2/18 ,  A61F2/82 ,  A61B17/3207 ,  A61B17/34 ,  A61B5/00 ,  A61M25/00 ,  A61M31/00 ,  A61B17/22 ,  A61B5/06 ,  A61M25/10 ,  A61B17/24 ,  A61B19/00

CPC classification number: A61M31/002 ,  A61B5/06 ,  A61B5/064 ,  A61B5/411 ,  A61B17/24 ,  A61B17/320725 ,  A61B17/320758 ,  A61B17/320783 ,  A61B17/3478 ,  A61B34/20 ,  A61B2017/22061 ,  A61F2/18 ,  A61F2/82 ,  A61F2002/825 ,  A61F2250/0039 ,  A61M25/0029 ,  A61M25/007 ,  A61M25/10 ,  A61M2025/0037 ,  A61M2025/105 ,  A61M2025/1052

公开(公告)号：EP2535079A3

公开(公告)日：2013-02-13

申请号：EP12183000.4

申请日：2006-01-18

Applicant: Acclarent, Inc.

Inventor： Chang, John Y. ,  Makower, Joshua ,  Vrany, Julia D. ,  Lamson, Theodore, C. ,  Walke, Amrish, Jayprakash

IPC: A61M29/02 ,  A61B1/233

CPC classification number: A61B1/00154 ,  A61B1/233 ,  A61B5/062 ,  A61B5/745 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/24 ,  A61B18/24 ,  A61B50/13 ,  A61B50/15 ,  A61B50/20 ,  A61F11/00 ,  A61F11/002 ,  A61M25/0041 ,  A61M25/1002 ,  A61M25/1011 ,  A61M29/02 ,  A61M2025/0226 ,  A61M2025/0681 ,  A61M2025/09116 ,  A61M2025/09175 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2210/0675 ,  A61N7/022

Abstract: A device for lavage of a paranasal sinus having an ostium, said device comprising: a catheter (1800,1900) having a proximal end, a distal end, an infusion lumen (1812,1902), an aspiration lumen (1810,1914), an infusion outlet aperture (1806,1904) and an aspiration inlet aperture (1808); and a balloon (1804,1912) for occluding a paranasal sinus ostium located on the catheter proximal to the infusion fluid outlet aperture and aspiration inlet aperture, whereby lavage fluid may be infused through the infusion lumen, out of the infusion outlet aperture and into the paranasal sinus and such lavage fluid may then be aspirated from the paranasal sinus through the aspiration inlet aperture and through the aspiration lumen.

公开(公告)号：EP2532300A3

公开(公告)日：2013-01-16

申请号：EP12182998.0

申请日：2006-01-18

Applicant: Acclarent, Inc.

Inventor： Chang, John Y. ,  Makower, Joshua ,  Vrany, Julia D. ,  Lamson, Theodore, C. ,  Walke, Amrish, Jayprakash

IPC: A61B1/233 ,  A61M29/02

CPC classification number: A61B1/00154 ,  A61B1/233 ,  A61B5/062 ,  A61B5/745 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/24 ,  A61B18/24 ,  A61B50/13 ,  A61B50/15 ,  A61B50/20 ,  A61F11/00 ,  A61F11/002 ,  A61M25/0041 ,  A61M25/1002 ,  A61M25/1011 ,  A61M29/02 ,  A61M2025/0226 ,  A61M2025/0681 ,  A61M2025/09116 ,  A61M2025/09175 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2210/0675 ,  A61N7/022

Abstract: A device (900) for insertion into a paranasal sinus, Eustachian tube, naso- lacrimal duct or other anatomical structure of the ear, nose or throat and for guiding a second device to that paranasal sinus, Eustachian tube, naso-lacrimal duct or other anatomical structure, said device comprising: an elongate shaft (902) having a proximal end and a distal end, at least a portion of said shaft being formed of plastically deformable material such that it may be bent into a desired shape; a bulbous tip member (906) on the distal end of the shaft; and a handle (904) attached to the proximal end of the shaft. Suitably, the handle (904) is detachable from said proximal end of the shaft. Also provided is a system comprising a device (900) according to the invention in combination with a second device that is advanceable over the shaft (902) when the handle (904) is detached from the proximal end of the shaft.

公开(公告)号：EP2263738B1

公开(公告)日：2013-06-05

申请号：EP10182893.7

申请日：2005-07-18

Applicant: Acclarent, Inc.

Inventor： Makower, Joshua ,  Chang, John Y ,  Vrany, Julia D ,  Walke, Amrish, Jayprakash

IPC: A61M29/00 ,  A61K9/22 ,  A61B19/00 ,  A61M25/10 ,  A61F5/08 ,  A61B17/24 ,  A61B5/06 ,  A61B17/16 ,  A61B1/00

CPC classification number: A61M31/002 ,  A61B5/06 ,  A61B5/064 ,  A61B5/411 ,  A61B17/24 ,  A61B17/320725 ,  A61B17/320758 ,  A61B17/320783 ,  A61B17/3478 ,  A61B34/20 ,  A61B2017/22061 ,  A61F2/18 ,  A61F2/82 ,  A61F2002/825 ,  A61F2250/0039 ,  A61M25/0029 ,  A61M25/007 ,  A61M25/10 ,  A61M2025/0037 ,  A61M2025/105 ,  A61M2025/1052

公开(公告)号：EP2532384A3

公开(公告)日：2013-02-20

申请号：EP12183002.0

申请日：2006-01-18

Applicant: Acclarent, Inc.

Inventor： Chang, John Y. ,  Makower, Joshua ,  Vrany, Julia D. ,  Lamson, Theodore, C. ,  Walke, Amrish, Jayprakash

IPC: A61M31/00 ,  A61M25/10 ,  A61M29/02

CPC classification number: A61B1/00154 ,  A61B1/233 ,  A61B5/062 ,  A61B5/745 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/24 ,  A61B18/24 ,  A61B50/13 ,  A61B50/15 ,  A61B50/20 ,  A61F11/00 ,  A61F11/002 ,  A61M25/0041 ,  A61M25/1002 ,  A61M25/1011 ,  A61M29/02 ,  A61M2025/0226 ,  A61M2025/0681 ,  A61M2025/09116 ,  A61M2025/09175 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2210/0675 ,  A61N7/022

Abstract: A balloon catheter device (1400) for delivering a substance to an ostium of a paranasal sinus of a human or animal subject, said device comprising: a catheter shaft (1402) having a balloon inflation lumen; a balloon (1404) attached to the catheter shaft (1402) and in fluid communication with said balloon inflation lumen (1410); and characterized in that said device further comprises a porous outer sheath (1406) attached to the catheter shaft (1402) and surrounding the balloon, an agent delivery lumen (1412) in said catheter shaft (1402) in fluid communication with a region between the balloon (1404) and the porous sheath (1406), the balloon being inflatable for compressing the porous outer sheath (1406) against tissue within said paranasal ostium whereby a therapeutically effective amount of the substance introduced through said agent delivery lumen can pass through the porous outer sheath and into contact with the paranasal ostium.