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1.发明公开NOVEL TETRAHYDROPYRAZOLO[3,4-B]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 有权新型四氢[3,4-B] AZEPINDERIVATIVE及其使用代谢型谷氨酸受体的作为变构调节剂
公开(公告)号：EP2592932A2
公开(公告)日：2013-05-22
申请号：EP11807175.2
申请日：2011-07-11
IPC分类号： A01N43/00 , C07D498/00 , C07D513/00 , C07D515/00
CPC分类号： C07D513/12 , A23L5/00 , A61B5/00 , A61K9/0019 , A61K9/0095 , A61K9/06 , A61K9/10 , A61K9/2059 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K31/55 , A61K45/06 , C07D513/04 , C07D513/14 , A61K2300/00
摘要： The present invention relates to novel compounds of Formula (I), wherein M, A and Y are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mGluR
4 ") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR
4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR
4 is involved.-
2.发明授权NOVEL TETRAHYDROPYRAZOLO[3,4-B]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 有权NEUARTIGE TETRAHYDROPYRAZOL [3,4-B] AZEPINDERIVATIVE UND IHRE VERWENDUNG ALS ALLOSTERISCHE MODULATOREN VON METABOTROPEN GLUTAMATREZEPTOREN
公开(公告)号：EP2592932B1
公开(公告)日：2016-01-20
申请号：EP11807175.2
申请日：2011-07-11
CPC分类号： C07D513/12 , A23L5/00 , A61B5/00 , A61K9/0019 , A61K9/0095 , A61K9/06 , A61K9/10 , A61K9/2059 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K31/55 , A61K45/06 , C07D513/04 , C07D513/14 , A61K2300/00
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3.发明公开TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 审中-公开三环化合物AS变构调节代谢型谷氨酸受体
公开(公告)号：EP2595996A2
公开(公告)日：2013-05-29
申请号：EP11807173.7
申请日：2011-07-09
IPC分类号： C07D513/02
CPC分类号： C07D513/04 , A61K31/433 , A61K31/506 , A61K31/55 , A61K45/06 , C07D513/14
摘要： The present invention describes and claims compounds of the Structural Formula I, Structural Formula II, or Structural Formula III: wherein R
1 , R
2 , R
3 and R
3' are -H or methyl, or R
3 and R
3 taken together form a double bond, or R
3' is -H and R
2 and R
3 taken together form a spiro-cyclopropyl substituent, R
4 is -H or -F, and R5 is -H, methyl, -CI or -Br, Formula II wherein R
1 is -H, ethyl-, isopropyl-, cyclopropyl-, methyl- or methoxy-, R
4 is -H or -F, and "Y" is: (a) -CH
2 -; (b) -CR
6 H-0-CR
7 R
8 -, wherein R
6 , R
7 , and R
8 are independently - H or methyl; (c) -CR
6 H-N(R
9 )-CR
7 R
8 -, wherein R
6 , R
7 , and R
8 are independently -H or methyl; (d) -CH
2 -C(R
9 )(R
10 )-C(R
7 )(R
8 )-, wherein R
7 , R
8 , R
9 and R
10 are independently - H or -methyl, or both R
7 and R
8 are -F, R
9 and R
10 are independently -H or -methyl, or both R
9 and R
10 are -F, or R
9 and R
10 taken together are (0=), which together with the carbon to which they are attached forms a carbonyl group.-
4.发明公开NOVEL FUSED PYRAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 审中-公开新的稠吡唑衍生物及其作为变构调节代谢型谷氨酸受体
公开(公告)号：EP2593277A2
公开(公告)日：2013-05-22
申请号：EP11807174.5
申请日：2011-07-11
发明人： BOLEA,Christelle , CELANIRE, Sylvain , TANG, Lam , JONES, Philip , LIVERTON, Nigel J. , SOLL, Richard , DONG, Jinchao , LEI, Zhiyu , LIU, Fuquing , KONG, Yanling , JU, Yi , ZHANG, Haoyong , WEI, Jieping , WEI, Qaioxin , ZHANG, Mingxiang , LUO, Yunfu
IPC分类号： B26B5/00
CPC分类号： C07D513/12 , A23L27/2056 , A23L33/10 , A23V2002/00 , A61K9/0019 , A61K9/0095 , A61K9/06 , A61K9/10 , A61K9/2059 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K31/55 , A61K45/06 , C07D513/04 , C07D513/14 , A61K2300/00 , A23V2200/16 , A23V2200/322 , A23V2200/328
摘要： The present invention relates to novel compounds of Formula (I), wherein M, A and Y are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mGluR
4 ") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR
4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR
4 is involved.-
5.发明公开NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 审中-公开新颖的2-氨基-4-吡唑基THIAZOLDERIVATIVE及其作为代谢型谷氨酸受体的变构调节剂的使用
公开(公告)号：EP2595986A2
公开(公告)日：2013-05-29
申请号：EP11807181.0
申请日：2011-07-12
申请人： Addex Pharma SA
发明人： BOLEA, Christelle , CELANIRE, Sylvain , BOUDOU, Cedric , TANG, Lam , ROCHER, Jean-Philippe , LIVERTON, Nigel, J.
IPC分类号： C07D417/14
CPC分类号： C07D417/14 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D487/04
摘要： The present invention relates to novel compounds of Formula (1), wherein M, A and B are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mGluR4") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.
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