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1.发明公开NOVEL TETRAHYDROPYRAZOLO[3,4-B]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 有权新型四氢[3,4-B] AZEPINDERIVATIVE及其使用代谢型谷氨酸受体的作为变构调节剂
公开(公告)号：EP2592932A2
公开(公告)日：2013-05-22
申请号：EP11807175.2
申请日：2011-07-11
IPC分类号： A01N43/00 , C07D498/00 , C07D513/00 , C07D515/00
CPC分类号： C07D513/12 , A23L5/00 , A61B5/00 , A61K9/0019 , A61K9/0095 , A61K9/06 , A61K9/10 , A61K9/2059 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K31/55 , A61K45/06 , C07D513/04 , C07D513/14 , A61K2300/00
摘要： The present invention relates to novel compounds of Formula (I), wherein M, A and Y are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mGluR
4 ") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR
4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR
4 is involved.-
2.发明授权NOVEL TETRAHYDROPYRAZOLO[3,4-B]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 有权NEUARTIGE TETRAHYDROPYRAZOL [3,4-B] AZEPINDERIVATIVE UND IHRE VERWENDUNG ALS ALLOSTERISCHE MODULATOREN VON METABOTROPEN GLUTAMATREZEPTOREN
公开(公告)号：EP2592932B1
公开(公告)日：2016-01-20
申请号：EP11807175.2
申请日：2011-07-11
CPC分类号： C07D513/12 , A23L5/00 , A61B5/00 , A61K9/0019 , A61K9/0095 , A61K9/06 , A61K9/10 , A61K9/2059 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K31/55 , A61K45/06 , C07D513/04 , C07D513/14 , A61K2300/00
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公开(公告)号：EP2459582B1
公开(公告)日：2015-05-27
申请号：EP10737227.8
申请日：2010-07-27
CPC分类号： C07K5/0804 , A61K38/00
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公开(公告)号：EP2271345A1
公开(公告)日：2011-01-12
申请号：EP09739426.6
申请日：2009-04-16
发明人： LIVERTON, Nigel, J. , MCCAULEY, John, A. , BUTCHER, John, W. , GILBERT, Kevin, F. , MCINTYRE, Charles, J. , RUDD, Michael, T.
IPC分类号： A61K31/505
CPC分类号： C07K5/123 , A61K38/00 , C07D498/18 , C07K5/08 , C07K5/0804 , C07K5/0812
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
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公开(公告)号：EP3526196A1
公开(公告)日：2019-08-21
申请号：EP17860988.9
申请日：2017-10-09
发明人： RUDD, Michael, T. , MENG, Zhaoyang , WAI, Jenny , BENNETT, David Jonathan , BRNARDIC, Edward, J. , LIVERTON, Nigel, J. , STACHEL, Shawn, J. , HAN, Yongxin , TEMPEST, Paul , ZHU, Jiuxiang , XU, Xuewang , ZHU, Bin
IPC分类号： C07D211/08 , C07D211/14 , C07D401/02
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公开(公告)号：EP1913016B1
公开(公告)日：2013-01-16
申请号：EP06800513.1
申请日：2006-07-28
发明人： HOLLOWAY, M., Katharine , LIVERTON, Nigel, J. , MCCAULEY, John, A. , RUDD, Michael, T. , VACCA, Joseph, P. , LUDMERER, Steven, W. , OLSEN, David, B.
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/0827
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公开(公告)号：EP2542545A1
公开(公告)日：2013-01-09
申请号：EP11750145.2
申请日：2011-03-02
发明人： MCCOMAS, Casey, Cameron , LIVERTON, Nigel, J. , SOLL, Richard , LI, Peng , PENG, Xuanjia , WU, Hao , NARJES, Frank , HABERMANN, Joerg , KOCH, Uwe , LIU, Shilan
IPC分类号： C07D307/84 , C07D405/04 , C07D405/10 , A61K31/343 , A61P31/14
CPC分类号： C07D307/84 , A61K31/343 , A61K45/06 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/10 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D473/00 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 所公开的是用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的式（I）化合物，这些化合物的合成，以及这些化合物用于抑制HCV NS5B聚合酶活性的用途，用于治疗或预防HCV感染和用于抑制 在基于细胞的系统中HCV病毒复制和/或病毒产生。
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公开(公告)号：EP1879607B1
公开(公告)日：2014-11-12
申请号：EP06751833.2
申请日：2006-04-28
发明人： HOLLOWAY, M. Katharine , LIVERTON, Nigel, J. , LUDMERER, Steven, W. , MCCAULEY, John, A. , OLSEN, David, B. , RUDD, Michael, T. , VACCA, Joseph, P.
IPC分类号： A61K38/12
CPC分类号： C07K5/0808 , C07K5/0806 , C07K5/0812 , C07K5/0815 , C07K5/0821
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9.发明授权
公开(公告)号：EP1379520B2
公开(公告)日：2014-04-09
申请号：EP02721105.1
申请日：2002-02-20
发明人： CLAIBORNE, Christopher, F. , BUTCHER, John, W. , CLAREMON, David, A. , LIBBY, Brian, E. , LIVERTON, Nigel, J. , MUNSON, Peter, M. , NGUYEN, Kevin, T. , PHILLIPS, Brian , THOMPSON, Wayne , MCCAULEY, John, A.
IPC分类号： C07D401/12 , C07D471/08 , C07D487/04 , A61K31/444 , A61P29/02
CPC分类号： C07D409/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D451/02 , C07D471/04 , C07D473/16 , C07D473/34 , C07D475/08
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公开(公告)号：EP2268285A1
公开(公告)日：2011-01-05
申请号：EP09714973.6
申请日：2009-02-12
发明人： MCCAULEY, John, A. , LIVERTON, Nigel, J. , HARPER, Steven , MCINTYRE, Charles, A. , RUDD, Michael, T.
IPC分类号： A61K31/70
CPC分类号： C07K5/0812 , A61K38/212 , A61K38/215 , A61K38/217 , C07K5/06078 , C07K5/0808 , A61K2300/00
摘要： A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, B, Z, M, W and n are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.
摘要翻译： 一类式（I）的大环化合物，其中R 1，R 3，R 4，R a，R b，A，B，Z，M，W和n在本文中定义，其可用作病毒蛋白酶的抑制剂 特别是丙型肝炎病毒（HCV）NS3蛋白酶。 还提供了用于合成和使用这种大环化合物治疗或预防HCV感染的方法。
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