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1.发明公开NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 审中-公开新颖的2-氨基-4-吡唑基THIAZOLDERIVATIVE及其作为代谢型谷氨酸受体的变构调节剂的使用
公开(公告)号：EP2595986A2
公开(公告)日：2013-05-29
申请号：EP11807181.0
申请日：2011-07-12
申请人： Addex Pharma SA
发明人： BOLEA, Christelle , CELANIRE, Sylvain , BOUDOU, Cedric , TANG, Lam , ROCHER, Jean-Philippe , LIVERTON, Nigel, J.
IPC分类号： C07D417/14
CPC分类号： C07D417/14 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D487/04
摘要： The present invention relates to novel compounds of Formula (1), wherein M, A and B are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mGluR4") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.
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2.发明公开NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 有权新型吡唑衍生物及其代谢型谷氨酸受体及其作为正向变构调节
公开(公告)号：EP2456769A1
公开(公告)日：2012-05-30
申请号：EP10752176.7
申请日：2010-07-14
申请人： Addex Pharma SA
发明人： BOLEA, Christelle
IPC分类号： C07D417/04 , C07D417/14
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention relates to novel compounds of Formula (I), wherein M, P, X
1 , X
2 , (A)
m and (B)
n are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mGluR4") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.-
3.发明公开NOVEL TETRAHYDROPYRAZOLO[3,4-B]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 有权新型四氢[3,4-B] AZEPINDERIVATIVE及其使用代谢型谷氨酸受体的作为变构调节剂
公开(公告)号：EP2592932A2
公开(公告)日：2013-05-22
申请号：EP11807175.2
申请日：2011-07-11
IPC分类号： A01N43/00 , C07D498/00 , C07D513/00 , C07D515/00
CPC分类号： C07D513/12 , A23L5/00 , A61B5/00 , A61K9/0019 , A61K9/0095 , A61K9/06 , A61K9/10 , A61K9/2059 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K31/55 , A61K45/06 , C07D513/04 , C07D513/14 , A61K2300/00
摘要： The present invention relates to novel compounds of Formula (I), wherein M, A and Y are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mGluR
4 ") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR
4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR
4 is involved.-
4.发明公开PREPARATION OF 4-AMINO-THIAZOLES AND 3-AMINO-1,2,4-THIADIAZOLES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 审中-公开的4-氨基噻唑的制备，和3-氨基-1,2,4-噻二唑和它们作为变构调节剂代谢型谷氨酸受体使用
公开(公告)号：EP2523953A1
公开(公告)日：2012-11-21
申请号：EP11700191.7
申请日：2011-01-14
申请人： Addex Pharma SA
发明人： BOLEA, Christelle
IPC分类号： C07D417/04 , C07D417/14 , A61K31/4439 , A61P27/02 , A61P25/28 , A61P25/24 , A61P25/14 , A61P25/06 , A61P25/08 , A61P3/10
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention relates to novel compounds of Formula (I), wherein M, P, X, A and (B)
n are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mGluR4") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.-
5.发明授权NOVEL TETRAHYDROPYRAZOLO[3,4-B]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 有权NEUARTIGE TETRAHYDROPYRAZOL [3,4-B] AZEPINDERIVATIVE UND IHRE VERWENDUNG ALS ALLOSTERISCHE MODULATOREN VON METABOTROPEN GLUTAMATREZEPTOREN
公开(公告)号：EP2592932B1
公开(公告)日：2016-01-20
申请号：EP11807175.2
申请日：2011-07-11
CPC分类号： C07D513/12 , A23L5/00 , A61B5/00 , A61K9/0019 , A61K9/0095 , A61K9/06 , A61K9/10 , A61K9/2059 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K31/55 , A61K45/06 , C07D513/04 , C07D513/14 , A61K2300/00
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6.发明授权NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 有权新型吡唑衍生物及其代谢型谷氨酸受体及其作为正向变构调节
公开(公告)号：EP2456769B1
公开(公告)日：2013-06-26
申请号：EP10752176.7
申请日：2010-07-14
申请人： Addex Pharma SA
发明人： BOLEA, Christelle
IPC分类号： C07D417/04 , C07D417/14
CPC分类号： C07D417/04 , C07D417/14
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公开(公告)号：EP1603877B1
公开(公告)日：2008-11-26
申请号：EP04717193.9
申请日：2004-03-04
申请人： Addex Pharma SA
发明人： BOLEA, Christelle , MUTEL, Vincent , ROCHER, Jean-Philippe , BESSIS, Anne-Sophie , LE POUL, Emmanuel
IPC分类号： C07D213/73 , C07D213/74 , A61K31/44 , A61K31/444 , A61P25/00
CPC分类号： C07D213/73 , C07D213/74
摘要： The invention relates to novel aminopyridine derivatives of formula (I) wherein R1 is methyl an R4 and amino group NR6R7 and R5 forms an arylalkynyl- or heteroarylalkynyl-group. The compounds are useful in the prevention or treatment of central nervous system disorders as well as other disorders modulated by mGIuR5 receptors.
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