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公开(公告)号：EP2588322A2
公开(公告)日：2013-05-08
申请号：EP11810072.6
申请日：2011-06-24
CPC分类号： B01L3/0241 , B01L3/502784 , B41J2/14024
摘要： The invention provides droplet actuator assemblies and systems and methods of manufacturing the droplet actuator assemblies. In certain embodiments, two-piece enclosures are used to form a droplet actuator assembly that houses a droplet operations substrate. In certain other embodiments, one-piece enclosures are used to form a droplet actuator assembly that houses a droplet operations substrate. In the plastic injection molding process for forming substrates of the droplet actuator assemblies of the present invention may utilize insert molding (or overmolding) processes for forming a gasket in at least one substrate, thereby avoiding the need for providing and installing a separate gasket component. Further, the droplet actuator assemblies may include features that allow ultrasonic welding processes to be used for bonding substrates together. The manufacturing systems of the present invention for fabricating the droplet actuator assemblies may utilize continuous flow reel-to-reel manufacturing processes.
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公开(公告)号：EP2588322B1
公开(公告)日：2015-06-17
申请号：EP11810072.6
申请日：2011-06-24
CPC分类号： B01L3/0241 , B01L3/502784 , B41J2/14024
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公开(公告)号：EP2553473A2
公开(公告)日：2013-02-06
申请号：EP11766501.8
申请日：2011-03-30
CPC分类号： G01N27/44734 , B01F13/0071 , B01F13/0076 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L7/525 , B01L7/54 , B01L2200/027 , B01L2200/06 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , B01L2300/1805 , B01L2300/1827 , B01L2400/0427 , B01L2400/043 , B01L2400/0677 , B01L2400/0683 , G01N27/44791
摘要： The invention relates to a droplet actuator device and methods for integrated sample preparation and analysis of a biological sample. A droplet actuator device is provided for conducting droplet operations. The droplet actuator device may include a bottom substrate and a top substrate separated from each other to form a gap therebetween; an arrangement of droplet operations electrodes arranged on one or both of the bottom and/or top substrates for conducting droplet operations thereon; a reagent storage layer comprising one or more compartments bound to the top substrate; and one or more openings arranged to provide a fluidic path from the one or more compartments into the gap, upon breach of a breachable seal separating the one or more compartments and openings.
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