公开(公告)号：EP3903812A1

公开(公告)日：2021-11-03

申请号：EP21166650.8

申请日：2011-09-29

申请人： Agensys, Inc. ,  Seagen Inc.

发明人： SATPAEV, Daulet ,  MORRISON, Robert Kendall ,  MORRISON, Karen Jane Meyrick ,  GUDAS, Jean ,  JAKOBOVITS, Aya ,  TORGOV, Michael ,  AN, Zili

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K1/00 ,  C07K16/30 ,  A61K47/68

摘要： The present invention provides nucleotides encoding an anti-191P4D12 antibody or antigen binding fragment thereof, vectors comprising the nucleotides, and cells comprising the vectors. The invention further provides methods of producing the antibodies of the invention and its fragments as well as antibody-drug conjugates using the cells of the invention.

公开(公告)号：EP2621526B1

公开(公告)日：2018-06-06

申请号：EP11831345.1

申请日：2011-09-29

申请人： Agensys, Inc. ,  Seattle Genetics, Inc.

发明人： SATPAEV, Daulet ,  MORRISON, Robert, Kendall ,  MORRISON, Karen Jane, Meyrick ,  GUDAS, Jean ,  JAKOBOVITS, Aya ,  TORGOV, Michael ,  AN, Zili

IPC分类号： A61K47/68 ,  C07K16/30 ,  A61N5/10 ,  A61K39/00

CPC分类号： A61K47/48569 ,  A61K47/48384 ,  A61K47/48415 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6861 ,  A61K47/6889 ,  A61K2039/505 ,  A61N5/1001 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

公开(公告)号：EP2533804B1

公开(公告)日：2018-04-11

申请号：EP11740529.0

申请日：2011-02-08

申请人： Agensys, Inc.

发明人： TORGOV, Michael ,  MORRISON, Robert, Kendall ,  JAKOBOVITS, Aya ,  GUDAS, Jean ,  AN, Zili

IPC分类号： A61K47/68 ,  C07K16/28 ,  A61K39/395 ,  C07K16/30 ,  A61K39/00

CPC分类号： A61K47/6811 ,  A61K39/39558 ,  A61K47/6849 ,  A61K47/6861 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3038 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/92

摘要： Antibody drug conjugates (ADC's) that bind to 161P2F10B protein are described herein. 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

公开(公告)号：EP2403524A1

公开(公告)日：2012-01-11

申请号：EP10756560.8

申请日：2010-03-05

申请人： Agensys, Inc. ,  Seattle Genetics, Inc.

发明人： GUDAS, Jean ,  JAKOBOVITS, Aya ,  AN, Zili ,  MORRISON, Robert, Kendall ,  MORRISON, Karen, Jane Meyrick ,  JIA, Xiao-Chi ,  BENJAMIN, Dennis ,  MOSER, Ruth ,  SENTER, Peter

IPC分类号： A61K39/00 ,  C12P21/08

CPC分类号： C07K16/30 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6863 ,  A61K2039/505 ,  C07K16/3046

摘要： Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

公开(公告)号：EP3494996A1

公开(公告)日：2019-06-12

申请号：EP18205129.2

申请日：2013-08-23

申请人： Agensys, Inc. ,  Seattle Genetics, Inc.

发明人： MORRISON, Robert, Kendall ,  AN, Zili ,  MORRISON, Karen Jane, Meyrick ,  SNYDER, Josh ,  JIA, Xiao-chi

IPC分类号： A61K47/68 ,  A61K39/395 ,  C07K16/18 ,  C07K16/30 ,  A61P35/00 ,  C12P21/08 ,  C12N5/071

摘要： The invention provides an antibody-drug conjugate comprising an anti-158P1D7 antibody or antigen binding fragment thereof conjugated to monomethyl auristatin E (MMAE), wherein the antibody or fragment thereof comprises a heavy chain variable region comprising an amino acid sequence at least 80% homologous to the heavy chain variable region amino acid sequence set forth in SEQ ID NO:7 and a light chain variable region comprising an amino acid sequence at least 80% homologous to the light chain variable region amino acid sequence set forth in SEQ ID NO:8.

公开(公告)号：EP3409287A1

公开(公告)日：2018-12-05

申请号：EP18171803.2

申请日：2011-09-29

申请人： Agensys, Inc. ,  Seattle Genetics, Inc.

发明人： SATPAEV, Daulet ,  MORRISON, Robert Kendall ,  MORRISON, Karen Jane Meyrick ,  GUDAS, Jean ,  JAKOBOVITS, Aya ,  TORGOV, Michael ,  AN, Zili

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K1/00 ,  C07K16/30 ,  A61K47/68 ,  A61N5/10

CPC分类号： A61K47/48569 ,  A61K47/48384 ,  A61K47/48415 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6861 ,  A61K47/6889 ,  A61K2039/505 ,  A61N5/1001 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

摘要： The present disclosure relates to antibody drug conjugates (ADC's) with auristatin E that binds to 191P4D12 protein and variants thereof. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in some cancers. The ADC's of provide a therapeutic composition for the treatment of cancer.

公开(公告)号：EP3395361A1

公开(公告)日：2018-10-31

申请号：EP18162821.5

申请日：2011-02-08

申请人： Agensys, Inc.

发明人： TORGOV, Michael ,  MORRISON, Robert Kendall ,  JAKOBOVITS, Aya ,  GUDAS, Jean ,  AN, Zili

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61K47/68

CPC分类号： A61K47/6811 ,  A61K39/39558 ,  A61K47/6849 ,  A61K47/6861 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3038 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/92

摘要： The present invention provides antibody drug conjugates or antigen binding fragment thereof that bind to 161P2F10B protein, wherein the antibody or antigen binding fragment thereof is conjugated to one or more units of monomethyl auristatin F (MMAF), each unit being conjugated via a linker. Provided are also antibody drug conjugates for use as a medicament, and pharmaceutical compositions that comprise the antibody drug conjugates in a human unit dose form. Further provided are antibody drug conjugates or the pharmaceutical compositions of the invention for use in treating cancer/tumor or inhibiting cancer/tumor growth in a subject.

公开(公告)号：EP2533804A1

公开(公告)日：2012-12-19

申请号：EP11740529.0

申请日：2011-02-08

申请人： Agensys, Inc.

发明人： TORGOV, Michael ,  MORRISON, Robert, Kendall ,  JAKOBOVITS, Aya ,  GUDAS, Jean ,  AN, Zili

IPC分类号： A61K39/00

CPC分类号： A61K47/48607 ,  A61K39/39558 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6861 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3038 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/92

摘要： Antibody drug conjugates (ADC's) that bind to 161P2F10B protein are described herein. 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

公开(公告)号：EP2887959A1

公开(公告)日：2015-07-01

申请号：EP13831502.3

申请日：2013-08-23

申请人： Agensys, Inc. ,  Seattle Genetics, Inc. ,  Morrison, Robert, Kendall ,  An, Zili ,  Morrison, Karen Jane, Meyrick ,  Snyder, Josh ,  Jia, Xiao-chi

发明人： MORRISON, Robert, Kendall ,  AN, Zili ,  MORRISON, Karen Jane, Meyrick ,  SNYDER, Josh ,  JIA, Xiao-chi

IPC分类号： A61K39/395 ,  C12P21/08 ,  C12N5/071 ,  C07K19/00

CPC分类号： C07K16/30 ,  A61K45/06 ,  A61K47/6811 ,  A61K47/6813 ,  A61K47/6817 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6861 ,  A61K47/6865 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3038 ,  C07K16/3053 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  A61K39/395 ,  A61K2300/00

摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

摘要翻译： 本文描述了结合158P1D7蛋白及其变体的抗体药物偶联物（ADC）。 158P1D7在正常成人组织中表现出组织特异性表达，并且在胶质母细胞瘤，肺癌，膀胱癌和乳腺癌中异常表达。 因此，本发明的ADC提供了用于治疗癌症的治疗组合物。

公开(公告)号：EP2621526A1

公开(公告)日：2013-08-07

申请号：EP11831345.1

申请日：2011-09-29

申请人： Agensys, Inc. ,  Seattle Genetics, Inc.

发明人： SATPAEV, Daulet ,  MORRISON, Robert, Kendall ,  MORRISON, Karen Jane, Meyrick ,  GUDAS, Jean ,  JAKOBOVITS, Aya ,  TORGOV, Michael ,  AN, Zili

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K1/00

CPC分类号： A61K47/6851 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6861 ,  A61K47/6889 ,  A61K2039/505 ,  A61N5/1001 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.