-
公开(公告)号：EP3903812A1
公开(公告)日：2021-11-03
申请号：EP21166650.8
申请日：2011-09-29
申请人： Agensys, Inc. , Seagen Inc.
发明人： SATPAEV, Daulet , MORRISON, Robert Kendall , MORRISON, Karen Jane Meyrick , GUDAS, Jean , JAKOBOVITS, Aya , TORGOV, Michael , AN, Zili
IPC分类号： A61K39/00 , A61K39/395 , C07K1/00 , C07K16/30 , A61K47/68
摘要： The present invention provides nucleotides encoding an anti-191P4D12 antibody or antigen binding fragment thereof, vectors comprising the nucleotides, and cells comprising the vectors. The invention further provides methods of producing the antibodies of the invention and its fragments as well as antibody-drug conjugates using the cells of the invention.
-
2.发明授权
公开(公告)号：EP2533804B1
公开(公告)日：2018-04-11
申请号：EP11740529.0
申请日：2011-02-08
申请人： Agensys, Inc.
IPC分类号： A61K47/68 , C07K16/28 , A61K39/395 , C07K16/30 , A61K39/00
CPC分类号： A61K47/6811 , A61K39/39558 , A61K47/6849 , A61K47/6861 , A61K2039/505 , C07K16/28 , C07K16/3038 , C07K2317/21 , C07K2317/56 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 161P2F10B protein are described herein. 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
-
公开(公告)号：EP1874822A1
公开(公告)日：2008-01-09
申请号：EP06735383.9
申请日：2006-02-15
申请人： Agensys, Inc.
发明人： GUDAS, Jean , JAKOBOVITS, Aya , JIA, Xiao-Chi , MORRISON, Robert, Kendall , CHALLITA-EID, Pia, M. , RAITANO, Arthur, B.
CPC分类号： A61K9/0019 , A61K2039/505 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/77
摘要： Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
-
公开(公告)号：EP3409287A1
公开(公告)日：2018-12-05
申请号：EP18171803.2
申请日：2011-09-29
发明人： SATPAEV, Daulet , MORRISON, Robert Kendall , MORRISON, Karen Jane Meyrick , GUDAS, Jean , JAKOBOVITS, Aya , TORGOV, Michael , AN, Zili
CPC分类号： A61K47/48569 , A61K47/48384 , A61K47/48415 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： The present disclosure relates to antibody drug conjugates (ADC's) with auristatin E that binds to 191P4D12 protein and variants thereof. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in some cancers. The ADC's of provide a therapeutic composition for the treatment of cancer.
-
公开(公告)号：EP3395361A1
公开(公告)日：2018-10-31
申请号：EP18162821.5
申请日：2011-02-08
申请人： Agensys, Inc.
CPC分类号： A61K47/6811 , A61K39/39558 , A61K47/6849 , A61K47/6861 , A61K2039/505 , C07K16/28 , C07K16/3038 , C07K2317/21 , C07K2317/56 , C07K2317/92
摘要： The present invention provides antibody drug conjugates or antigen binding fragment thereof that bind to 161P2F10B protein, wherein the antibody or antigen binding fragment thereof is conjugated to one or more units of monomethyl auristatin F (MMAF), each unit being conjugated via a linker. Provided are also antibody drug conjugates for use as a medicament, and pharmaceutical compositions that comprise the antibody drug conjugates in a human unit dose form. Further provided are antibody drug conjugates or the pharmaceutical compositions of the invention for use in treating cancer/tumor or inhibiting cancer/tumor growth in a subject.
-
6.发明公开
公开(公告)号：EP2533804A1
公开(公告)日：2012-12-19
申请号：EP11740529.0
申请日：2011-02-08
申请人： Agensys, Inc.
IPC分类号： A61K39/00
CPC分类号： A61K47/48607 , A61K39/39558 , A61K47/6811 , A61K47/6849 , A61K47/6861 , A61K2039/505 , C07K16/28 , C07K16/3038 , C07K2317/21 , C07K2317/56 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 161P2F10B protein are described herein. 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
-
7.发明公开
公开(公告)号：EP1863848A2
公开(公告)日：2007-12-12
申请号：EP06749164.7
申请日：2006-03-31
申请人： Agensys, Inc.
发明人： JAKOBOVITS, Aya , KANNER, Steven, B. , CHALLITA-EID, Pia, M. , PEREZ-VILLAR, Juan, J. , SATPAEV, Daulet , RAITANO, Arthur, B. , MORRISON, Robert, Kendall , MORRISON, Karen, Jane, Meyrick , JIA, Xiao-chi , GUDAS, Jean
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
-
8.发明公开ANTIBODIES AND MOLECULES DERIVED THEREFROM THAT BIND TO STEAP-1 PROTEINS 有权抗体和它们的衍生物分子是否涉及STEAP-1蛋白结合
公开(公告)号：EP1742966A2
公开(公告)日：2007-01-17
申请号：EP04750565.6
申请日：2004-04-22
申请人： Agensys, Inc.
发明人： JAKOBOVITS, Aya , ETESSAMI, Soudabeh , CHALLITA-EID, Pia, M. , PEREZ-VILLAR, Juan, J. , MORRISON, Karen, J. , JIA, Xiao-Chi , FARIS, Mary , GUDAS, Jean , RAITANO, Arthur, B.
IPC分类号： C07K16/00
CPC分类号： C07K16/40 , A61K39/39533 , A61K45/06 , A61K47/48607 , A61K47/6861 , A61K51/106 , A61K51/1075 , A61K2039/505 , C07H21/04 , C07K16/3069 , C07K2317/24 , C07K2317/565 , G01N33/6887 , A61K2300/00
摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
-
9.发明公开
公开(公告)号：EP2403524A1
公开(公告)日：2012-01-11
申请号：EP10756560.8
申请日：2010-03-05
发明人： GUDAS, Jean , JAKOBOVITS, Aya , AN, Zili , MORRISON, Robert, Kendall , MORRISON, Karen, Jane Meyrick , JIA, Xiao-Chi , BENJAMIN, Dennis , MOSER, Ruth , SENTER, Peter
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6863 , A61K2039/505 , C07K16/3046
摘要： Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
-
公开(公告)号：EP2185574A2
公开(公告)日：2010-05-19
申请号：EP08799268.1
申请日：2008-09-05
申请人： Agensys, Inc.
发明人： RAITANO, Arthur, B. , MORRISON, Robert, Rendall , MORRISON, Karen Jane, Mayrick , KANMER, Steven, B. , CHALLITA-EID, Pia, M. , JIA, Xiao-chi , GUDAS, Jean , JAKOBOVITS, Aya
IPC分类号： C07H21/02 , A61K31/713
CPC分类号： G01N33/57484 , A01K2267/0331 , A61K51/1045 , C07K16/30 , C07K16/3015 , C07K16/303 , C07K16/3046 , C07K2317/56 , C07K2317/732 , C07K2317/77 , G01N2500/00
摘要： Antibodies and molecules derived therefrom that bind to 24P4C12 protein and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译： 描述了结合24P4C12蛋白及其变体的由其衍生的抗体和分子，其中24P4C12在正常成人组织中表现出组织特异性表达，并在表I中列出的癌症中异常表达。因此，24P4C12提供了诊断，预后，预防和 /或癌症的治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.044 秒)
