公开(公告)号：EP0912465A1

公开(公告)日：1999-05-06

申请号：EP97934936.0

申请日：1997-07-15

申请人： Allergan Sales, Inc.

发明人： DOLBY, Lloyd, J. ,  FEDORUK, Nestor, A. ,  ESFANDIARI, Shervin ,  CHAMBERLAIN, Natalie, C. ,  GARST, Michael, E.

IPC分类号： C07B31 ,  C07C5 ,  C07C13 ,  C07C29 ,  C07C31 ,  C07C41 ,  C07C43 ,  C07C45 ,  C07C47 ,  C07C209 ,  C07C211 ,  C07C231 ,  C07C233 ,  C07C319 ,  C07C321 ,  C07D233 ,  C07D403

CPC分类号： C07C5/11 ,  C07B31/00 ,  C07C29/132 ,  C07C41/18 ,  C07C45/41 ,  C07C45/62 ,  C07C209/40 ,  C07C209/48 ,  C07C209/50 ,  C07C209/52 ,  C07C231/08 ,  C07C231/12 ,  C07C319/02 ,  C07C319/06 ,  C07C2601/16 ,  C07C2602/10 ,  C07C2603/74 ,  C07D233/06 ,  C07D233/10 ,  C07C13/48 ,  C07C31/137 ,  C07C47/02 ,  C07C49/403 ,  C07C321/26 ,  C07C233/05 ,  C07C211/07 ,  C07C211/35 ,  C07C211/48 ,  C07C43/188

摘要： The invention is directed to a process for reducing or reductively cleaving an organic compound susceptible to dissolving metal reduction comprising exposing the organic compound to a solution of lithium in a polyamine including at leat two amino groups, selected from the group consisting of primary and secondary amino groups and mixtures thereof, e.g. ethylenediamine and R-NH2, optionally containing a lower alkyl alcohol, wherein R is chosen from the group consisting of ethyl, propyl, and butyl, including all straight and branched chain isomers thereof, for a time sufficient to effect reduction.

公开(公告)号：EP0912465B1

公开(公告)日：2001-04-04

申请号：EP97934936.2

申请日：1997-07-15

申请人： Allergan Sales, Inc.

发明人： DOLBY, Lloyd, J. ,  FEDORUK, Nestor, A. ,  ESFANDIARI, Shervin ,  CHAMBERLAIN, Natalie, C. ,  GARST, Michael, E.

IPC分类号： C07B31/00 ,  C07C13/28 ,  C07C5/11 ,  C07C29/132 ,  C07C209/52 ,  C07C231/08 ,  C07C319/02

CPC分类号： C07C5/11 ,  C07B31/00 ,  C07C29/132 ,  C07C41/18 ,  C07C45/41 ,  C07C45/62 ,  C07C209/40 ,  C07C209/48 ,  C07C209/50 ,  C07C209/52 ,  C07C231/08 ,  C07C231/12 ,  C07C319/02 ,  C07C319/06 ,  C07C2601/16 ,  C07C2602/10 ,  C07C2603/74 ,  C07D233/06 ,  C07D233/10 ,  C07C13/48 ,  C07C31/137 ,  C07C47/02 ,  C07C49/403 ,  C07C321/26 ,  C07C233/05 ,  C07C211/07 ,  C07C211/35 ,  C07C211/48 ,  C07C43/188

摘要： The invention is directed to a process for reducing or reductively cleaving an organic compound susceptible to dissolving metal reduction comprising exposing the organic compound to a solution of lithium in a polyamine including at leat two amino groups, selected from the group consisting of primary and secondary amino groups and mixtures thereof, e.g. ethylenediamine and R-NH2, optionally containing a lower alkyl alcohol, wherein R is chosen from the group consisting of ethyl, propyl, and butyl, including all straight and branched chain isomers thereof, for a time sufficient to effect reduction.

摘要翻译： 本发明涉及减少或还原性裂解易溶解金属还原的有机化合物的方法，其包括将有机化合物暴露于含有至少两个氨基的多胺中的锂溶液中，所述多胺选自伯和仲氨基 基团及其混合物，例如 乙二胺和R-NH 2，任选地含有低级烷基醇，其中R选自乙基，丙基和丁基，包括其所有直链和支链异构体，其时间足以实现还原。

公开(公告)号：EP0740665B1

公开(公告)日：2000-12-06

申请号：EP95908537.4

申请日：1995-01-17

申请人： Allergan Sales, Inc.

发明人： GARST, Michael, E. ,  DOLBY, Lloyd, J. ,  FEDORUK, Nestor, A.

IPC分类号： C07D311/74 ,  C07D335/06

CPC分类号： C07D335/06 ,  C07D311/58

摘要： A process of preparing intermediates useful in making compounds with retinoic acid-like activity is disclosed. The intermediates are halogenated chromans and thiochromans of formula (I) shown above and are prepared by the alkylation of a phenol or thiophenol with an alkene compound (the starting materials shown in the formula above), cyclization and halogenation. In the formula the symbols have the following meanings: R1 and R2 are C1 to C4 alkyl, R3 is H or C1 to C4 alkyl, X is oxygen or sulfur, Y is a leaving group, and Z is chlorine, bromine or iodine.