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公开(公告)号：EP1758902A1
公开(公告)日：2007-03-07
申请号：EP05754207.8
申请日：2005-06-14
申请人： Altana Pharma AG
发明人： BUHR, Wilm , ZIMMERMANN, Peter, Jan , BREHM, Christof , PALMER, Andreas , CHIESA, M., Vittoria , SIMON, Wolfgang-Alexander , POSTIUS, Stefan , KROMER, Wolfgang , STURM, Ernst
IPC分类号： C07D471/04 , A61K31/437 , A61P1/04
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I) and to medicaments comprising these compounds.
摘要翻译： 本发明涉及式（I）的化合物和包含这些化合物的药物。
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2.发明公开INTERMEDIATES FOR THE PREPARATION OF TRICYCLIC DIHYDROPYRANO -IMIDAZO -PYRIDINES DERIVATIVES 审中-公开中间产品为演示文稿三环DIHYDROPYRANOIMIDAZOPYRIDINDERIVATE
公开(公告)号：EP1697358A1
公开(公告)日：2006-09-06
申请号：EP04804906.8
申请日：2004-12-17
申请人： Altana Pharma AG
发明人： PALMER, Andreas , NETTEKOVEN, Ulrike , ZIMMERMANN, Peter, Jan , BREHM, Christof , CHIESA, M.Vittoria , BUHR, Wilm
IPC分类号： C07D471/04 , C07D493/14
CPC分类号： C07D491/147 , C07D471/04
摘要： The invention relates to compounds of the formula (I), in which R1, R2, R3, Arom and PG have the meanings as indicated in the description. These compounds are valuable intermediates for the preparation of pharmaceutically active compounds.
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公开(公告)号：EP1565465A1
公开(公告)日：2005-08-24
申请号：EP03779937.6
申请日：2003-11-15
申请人： ALTANA Pharma AG
发明人： BUHR, Wilm , SENN-BILFINGER, Jörg , ZIMMERMANN, Peter, Jan , SIMON, Wolfgang-Alexander , POSTIUS, Stefan , KROMER, Wolfgang
IPC分类号： C07D471/04 , A61P1/04
CPC分类号： C07D471/04
摘要： The invention relates to 8-substituted imidazopyridines of a certain formula(1), in which the substituents and symbols have the meanings indicated in the description. The compounds have gastric secretion inhibiting and excellent gastric and intestinal protective action properties.
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4.发明公开AMINO-SUBSTITUTED IMIDAZOPYRIDINES FOR THE TREATMENT OF GASTROINTESTINAL DISEASES 审中-公开氨基咪唑并吡啶用于治疗胃肠道疾病
公开(公告)号：EP1417208A1
公开(公告)日：2004-05-12
申请号：EP02762419.6
申请日：2002-07-31
申请人： ALTANA Pharma AG
发明人： SENN-BILFINGER, Jörg , ZIMMERMANN, Peter, Jan , BUHR, Wilm , SIMON, Wolfgang-Alexander , POSTIUS, Stefan , KROMER, Wolfgang
IPC分类号： C07D471/14 , A61K31/435 , C07D491/14 , A61P1/04 , A61K31/35
CPC分类号： C07D471/14
摘要： Compounds of the formula (I), in which the substituents and symbols are as defined in the description are suitable for preventing and treating gastrointestinal disorders.
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5.发明公开7, 8, 9, 10- TETRAHYDRO-IMIDAZO [2,1-A] ISOQUINOLINE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS 审中-公开-7,8,9,10-四氢[2,1-A]异喹啉衍生物和它们作为胃酸分泌抑制剂的用途
公开(公告)号：EP1805173A2
公开(公告)日：2007-07-11
申请号：EP05747516.2
申请日：2005-03-18
申请人： Altana Pharma AG
发明人： PALMER, Andreas , BREHM, Christof , CHIESA, M., Vittoria , ZIMMERMANN, Peter, Jan , BUHR, Wilm , SIMON, Wolfgang-Alexander , KROMER, Wolfgang , POSTIUS, Stefan
IPC分类号： C07D471/04 , A61K31/4745
CPC分类号： C07D471/04
摘要： The invention provides compounds of the formula (1) in which R1 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 1-4C-alkoxy-1-4C-alkyl or 1-4C-alkoxycarbonyl, 2-4C-alkenyl, 2-4C-alkinyl, fluoro-1-4C-alkyl or hydroxy-1-4C-alkyl R2 is hydrogen, 1-4C-alkyl, 3-7C-cydoalkyl, 3-7C-cycloalkyl-1-4C-alkyl, halogen, 2-4C-alkenyl, 2-4C-alkynyl, hydroxy-1-4C-alkyl, hydroxy-3-4-C-alkenyl, hydroxy-3-4C-alkinyl, 1-4-Calkoxycarbonyl, fluoro-1-4C-alkyl, cyanomethyl, hydroxy, 1-4C-alkoxy, amino, mono- or di-1-4C-alkylamino, 1-4C-alkylcarbonylamino, 1-4C-alkoxycarbonylamino, carboxyl, mono- or di-1-4Calkylamino-1-4C-alkyl, 1-4C-alkylcarbonyl, 2-4C-alkenylcarbonyl, 2-4C-alkinylcarbonyl. or the radical -CO-NR21 R22, R3 is hydroxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkoxy-1-4C-alkyl, carboxyl, 1-4C-alkoxycarbonyl or the radical -CO-NR31 R32, Arom is a R4-, R5-, R6- and R7- substituted mono- or bicyclic aromatic radical selected from the group consisting of phenyl, naphthyl, pyrrolyl, pyrazolyl, imidazolyl, 1,2,3-triazolyl, indolyl, benzimidazolyl, furanyl (furyl), benzofuranyl.(benzofuryl), thiophenyl (thienyl), benzothiophenyl (benzothienyl), thiazolyl, isoxazolyl, pytidinyl, pyrimidinyl, quinolinyl and isoquinolinyl. The compounds inhibit the secretion of gastric acid.
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6.发明公开PHARMACEUTICAL COMBINATIONS OF A PROTON PUMP INHIBITOR AND A COMPOUND WHICH MODIFIES GASTROINTESTINAL MOTILITY 审中-公开质子泵抑制剂的药物组合，并进行修改肠胃蠕动的连接
公开(公告)号：EP1644043A1
公开(公告)日：2006-04-12
申请号：EP04741658.1
申请日：2004-05-26
申请人： ALTANA Pharma AG
发明人： BUHR, Wilm , POSTIUS, Stefan , ZIMMERMANN, Peter, Jan , CHIESA, M., Vittoria , PALMER, Andreas , BREHM, Christof , KLEIN, Thomas , SENN-BILFINGER, Joerg , SIMON, Wolfgang-Alexander , KROMER, Wolfgang , GRUNDLER, Gerhard , HANAUER, Guido
CPC分类号： A61K45/06
摘要： The invention relates to the combination of certain active compounds from the acid pump antagonist class and compounds, which modify gastrointestinal motility.
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公开(公告)号：EP1419163B9
公开(公告)日：2005-11-09
申请号：EP02794528.6
申请日：2002-07-31
申请人： ALTANA Pharma AG
发明人： BUHR, Wilm , SENN-BILFINGER, Jörg , ZIMMERMANN, Peter, Jan , SIMON, Wolfgang-Alexander , POSTIUS, Stefan , KROMER, Wolfgang
IPC分类号： C07D491/04 , A61K31/45
CPC分类号： C07D491/14
摘要： The invention provides compounds of the formula (I), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.
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8.发明公开4-SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS INHIBITORS OF GASTRIC SECRETION 审中-公开4-取代的苯并咪唑和它们作为胃酸分泌使用
公开(公告)号：EP1575924A1
公开(公告)日：2005-09-21
申请号：EP03785790.1
申请日：2003-12-11
申请人： ALTANA Pharma AG
发明人： BUHR, Wilm , ZIMMERMANN, Peter, Jan , CHIESA, Vittoria , PALMER, Andreas , BREHM, Christof , GRUNDLER, Gerhard , SENN-BILFINGER, Jörg , SIMON, Wolfgang-Alexander , POSTIUS, Stefan , KROMER, Wolfgang
IPC分类号： C07D235/06 , C07D235/08 , C07D235/12 , C07D403/04 , C07D403/06 , C07D413/04 , A61K31/4184 , A61K31/422 , A61K31/4245 , A61P1/04
CPC分类号： C07D235/06 , C07D235/08 , C07D235/12 , C07D403/06 , C07D413/04
摘要： The invention relates to 6-substituted benzimidazoles of formula 1, in which X is O (oxygen) or NH and Y has either the meaning -CH2-Ar wherein Ar is a mono- or bicyclic aromatic residue, or Y denotes the group gp, formula (gp) wherein Z has the meaning -CHR8- or -CHR8-CHR9-. The compounds have gastric secretion inhibiting and excellent gastric and intestinal protective action properties.
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公开(公告)号：EP1414821A1
公开(公告)日：2004-05-06
申请号：EP02760296.0
申请日：2002-07-31
申请人： ALTANA Pharma AG
IPC分类号： C07D471/14
CPC分类号： C07D471/14 , C07D491/14
摘要： The invention relates to compounds of Formula (1), in which the substituents and symbols have the meanings indicated in the description. The compounds are valuable intermediates for the preparation of pharmaceutical active compounds.
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10.发明公开1,2,4-TRIAZOLO[4,3-A]PYRIDINES USEFUL IN THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开1,2,4-三唑并[4,3-a]吡啶所产生胃肠道障碍的治疗是合适的
公开(公告)号：EP1718646A1
公开(公告)日：2006-11-08
申请号：EP05708035.0
申请日：2005-02-17
申请人： Altana Pharma AG
发明人： BUHR, Wilm , ZIMMERMANN, Peter, Jan , BREHM, Christof , PALMER, Andreas , CHIESA, M., Vittoria , SIMON, Wolfgang-Alexander , POSTIUS, Stefan , KROMER, Wolfgang
IPC分类号： C07D471/04 , A61P1/04 , A61K31/424 , C07D333/38 , C07D333/24 , C07D277/56 , C07D277/30 , C07D213/87 , C07D213/54 , C07D215/54 , C07D215/12
CPC分类号： C07D213/54 , C07D213/87 , C07D215/12 , C07D215/54 , C07D277/30 , C07D277/56 , C07D333/24 , C07D333/38 , C07D471/04
摘要： The invention provides compounds of the formula (1), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.
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