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    Transdermal drug delievery patch system, method of making same and method of using same
    2.
    发明公开
    Transdermal drug delievery patch system, method of making same and method of using same 有权
    补丁系统zur transdermalen Arzneimittelverabreichung，Herstellungsverfahren und Verwendungsverfahren

    公开(公告)号：EP2319578A1

    公开(公告)日：2011-05-11

    申请号：EP10182248.4

    申请日：2003-03-11

    申请人： Altea Therapeutics Corporation

    发明人： Eppstein, Jonathan ,  McRae, Stuart ,  Smith, Alan

    IPC分类号： A61N1/30

    CPC分类号： A61M37/0015 ,  A61M37/00 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2210/04 ,  A61M2230/20 ,  A61N1/0424 ,  A61N1/044 ,  A61N1/0476 ,  A61N1/325 ,  A61N1/326 ,  A61N1/327

    摘要： The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: a) an actuator comprising; i) an outer body defining a top of the actuator, the outer body containing a cavity; ii) a controller board comprising driving electronics and a battery, the controller board being positioned within the cavity; and iii) an interface connection port for receiving a porator array, the interface connection port containing an anode and a cathode; b) the porator array comprising: i) a top surface, with a removable adhesive attached to the top surface, the top surface containing two concentric electrical contact rings for contacting the interface connection port at the anode and the cathode upon removal of the adhesive layer; ii) a bottom surface comprising a tissue interface membrane, the tissue interface membrane further comprising a substrate with at least one porator contained on or within the substrate, the bottom surface further comprising an adhesive layer for attaching the porator array to a tissue membrane; and iii) an extension tab laterally and removably attached to the bottom surface, the extension tab including an adhesive applied on the bottom thereof, thereby allowing the extension tab to remain on the tissue membrane upon removal of the porator array; and iv) a release liner removably attached to the bottom surface; and c) a reservoir patch attached to the extension tab, the reservoir patch being applied to the microporated area of the tissue membrane after poration. The invention also provides for methods of making and methods of using the same.

    摘要翻译： 本发明提供了用于形成药物递送贴片系统的透皮药物递送装置，包括：a）致动器，包括： i）限定致动器顶部的外体，外体包含空腔; ii）控制器板，包括驱动电子器件和电池，所述控制器板定位在所述腔内; 以及iii）用于接收搬运器阵列的接口连接端口，所述接口连接端口包含阳极和阴极; b）所述搬运器阵列包括：i）顶表面，具有附着到所述顶表面的可移除粘合剂，所述顶表面包含两个同心的电接触环，用于在去除所述粘合剂层时接触阳极和阴极处的界面连接端口 ; ii）包含组织界面膜的底表面，所述组织界面膜还包括具有包含在所述基底上或内部的至少一个移位器的基底，所述底表面还包括用于将所述穿孔器阵列附接到组织膜的粘合剂层; 以及iii）延伸片横向地和可移除地附接到底部表面，延伸片包括施加在其底部上的粘合剂，从而允许延伸片在移除排列器阵列时保留在组织膜上; 以及iv）可移除地附接到所述底表面的释放衬垫; 以及c）附接到所述延伸片的储存器贴片，所述储存器贴片在穿孔后施加到所述组织膜的微孔区域。 本发明还提供了制备方法及其使用方法。