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1.发明授权ACETYLENIC ORTHO-SULFONAMIDO AND PHOSPHINIC ACID AMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS TACE INHIBITORS 有权乙酰乙酸异硫氰酸酯 - 磷酸二铵 - 二氯环己烷甲基胆碱酯酶抑制剂
公开(公告)号：EP1157024B1
公开(公告)日：2002-11-06
申请号：EP00905788.6
申请日：2000-01-27
IPC分类号： C07D471/04 , C07D498/04 , C07D215/54 , C07D513/04 , C07F9/53 , A61K31/437 , A61K31/47 , A61P19/02 , A61P37/00 , C07C309/42 , C07C309/87
CPC分类号： C07D471/04 , C07C309/42 , C07C309/87 , C07D215/54 , C07D513/04
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公开(公告)号：EP1147080A1
公开(公告)日：2001-10-24
申请号：EP00911652.6
申请日：2000-01-27
发明人： LEVIN, Jeremy, Ian , VENKATESAN, Aranapakam, Mudumbai , COLE, Derek, Cecil , CHEN, James, Ming , DAVIS, Jamie, Marie , GROSU, George, Theodore
IPC分类号： C07C317/44 , C07C323/60 , C07D213/56 , C07D209/18 , C07D209/48 , C07D211/34 , C07D215/48 , C07D217/26 , C07C259/06 , C07D295/08 , C07D309/04 , C07D311/84 , C07D333/24 , C07D333/68 , C07D335/02 , C07F9/53 , A61K31/16 , A61P19/02 , A61P37/00
CPC分类号： C07D209/48 , C07C259/06 , C07C317/44 , C07C323/60 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D211/34 , C07D213/56 , C07D215/48 , C07D215/54 , C07D217/06 , C07D295/088 , C07D309/04 , C07D311/84 , C07D333/24 , C07D333/60 , C07D335/04
摘要： The invention concerns compounds of formula (I) which are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
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公开(公告)号：EP1149074A1
公开(公告)日：2001-10-31
申请号：EP00905787.8
申请日：2000-01-27
IPC分类号： C07C323/49 , C07C327/06 , C07D295/12 , C07F9/53 , A61K31/18 , A61P19/02 , A61P37/00 , C07C309/42 , C07C309/87
CPC分类号： C07D295/13 , C07B53/00
摘要： Compounds of formula (B): (1a), or (1b), (1c) are provided wherein the variables are as defined herein which are useful in disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
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4.发明公开2, 3, 4, 5-TETRAHYDRO-1H-[1, 4] BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS 有权2,3,4,5-四氢-1H- [1,4]苯并咪唑-3-羟基苯并咪唑基金属蛋白酶
公开(公告)号：EP1147095A1
公开(公告)日：2001-10-24
申请号：EP00909990.4
申请日：2000-01-27
发明人： ALBRIGHT, Jay, Donald , DELOS SANTOS, Efren, Guillermo , LEVIN, Jeremy, Ian , CHEN, James, Ming
IPC分类号： C07D243/14 , C07D401/06 , C07D405/06 , C07D409/06 , C07D521/00 , A61K31/5513 , A61P35/00 , A61P19/02
CPC分类号： C07D401/06 , C07D243/14 , C07D405/06 , C07D409/06
摘要： Compounds having formula (1) are useful in treating disease conditions mediated by matrix metalloproteinases and TACE, such as tumor growth, osteoarthritis, rheumatoid arthritis and degenerative cartilage loss.
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5.发明公开ACETYLENIC ORTHO-SULFONAMIDO AND PHOSPHINIC ACID AMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS TACE INHIBITORS 有权炔邻磺酰，和膦酰胺 - 双环HETEROARYLHYDROXAMSÄUREAS TACE抑制剂
公开(公告)号：EP1157024A1
公开(公告)日：2001-11-28
申请号：EP00905788.6
申请日：2000-01-27
IPC分类号： C07D471/04 , C07D498/04 , C07D215/54 , C07D513/04 , C07F9/53 , A61K31/437 , A61K31/47 , A61P19/02 , A61P37/00 , C07C309/42 , C07C309/87
CPC分类号： C07D471/04 , C07C309/42 , C07C309/87 , C07D215/54 , C07D513/04
摘要： Compounds of formulas (a), (b), (c), or (d) are provided wherein P and Q are (e) or (f), provided that when P is (e), Q is (f), and vice versa; which are useful in disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
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6.发明公开ACETYLENIC ARYL SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS 有权炔ARYLSULFONAMID-和次膦酸酰胺异羟肟酸衍生物作为TACE抑制剂
公开(公告)号：EP1144369A2
公开(公告)日：2001-10-17
申请号：EP00913270.5
申请日：2000-01-27
IPC分类号： C07C311/00
CPC分类号： C07C309/42 , C07C311/29 , C07C2601/04 , C07F9/36
摘要： Hydroxamic acids having formula (B) wherein the variables are as defined herein, are useful in treating disease conditions mediated by TNF-α such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
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7.发明公开HETEROARYL ACETYLENIC SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS 有权与乙炔含磺酰胺和次膦酸酰胺异羟肟酸衍生物作为TACE抑制剂的杂芳基衍生物
公开(公告)号：EP1147102A2
公开(公告)日：2001-10-24
申请号：EP00913263.0
申请日：2000-01-27
IPC分类号： C07D333/00
CPC分类号： C07D213/78 , C07C309/42 , C07C309/87 , C07D231/42 , C07D333/38
摘要： Compounds of formula (I) are useful in treating disease conditions mediated by TNF-α such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
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8.发明公开ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS 有权炔基异羟肟取代的衍生物，它们的制备和它们作为基质金属蛋白酶（MMP）抑制剂/ TNF-ALPHA转化酶（TACE）抑制剂
公开(公告)号：EP1147085A1
公开(公告)日：2001-10-24
申请号：EP00904569.1
申请日：2000-01-27
发明人： LEVIN, Jeremy, Ian , VENKATESAN, Aranapakam, Mudumbai , CHEN, James, Ming , ZASK, Arie , SANDANAYAKA, Vincent, Premarana , DU, Mila, Ti , BAKER, Jannie, Lea
IPC分类号： C07D211/66 , A61K31/445 , C07D309/08 , A61K31/35 , C07D401/06 , C07D409/06 , C07D401/12 , C07D413/04 , C07D407/06 , A61P19/00 , A61P19/02
CPC分类号： C07D309/08 , A61K31/351 , A61K31/435 , A61K31/445 , A61K31/496 , C07D211/60 , C07D211/62 , C07D211/66
摘要： Compounds of formula (I) wherein R1 is hydrogen, aryl, heteroaryl, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, or -C4-C8-cycloheteroalkyl; R2 and R3 are hydrogen, alkyl of 1-6 carbon atoms, -CN, or CCH; R8, R9, R10 and R11 are hydrogen, aryl or heteroaryl, cycloalkyl of 3-6 carbon atoms, -C4-C8-cycloheteroalkyl, alkyl of 1-18 carbon atoms, alkenyl of 2-18 carbon atoms, alkynyl of 2-18 carbon atoms; with the proviso that one of the pairs R8 and R9, R9 and R10 or R10 and R11, together with the carbon atom or atoms to which they are attached, form a cycloalkyl ring of 3-6 carbon atoms, or a -C4-C8-cycloheteroalkyl ring; R12 is hydrogen, aryl or heteroaryl, cycloalkyl of 3-6 carbon atoms; -C4-C8-cycloheteroalkyl, or alkyl of 1-6 carbon atoms; A, X are O, S, SO, SO2, NR7, or CH2; Y is aryl or heteroaryl, with the proviso that A and X are not bonded to adjacent atoms of Y; and n is 0-2; or a pharmaceutically acceptable salt thereof; useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.
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9.发明公开ACETYLENIC (BETA)-SULFONAMIDO AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS 审中-公开磷酸二氢钠（BETA）-SULFONAMIDO UNDPHOSPHINSÄUREAMIDHYDROXAMSÄURETACE INHIBITOREN
公开(公告)号：EP1147078A1
公开(公告)日：2001-10-24
申请号：EP00904570.9
申请日：2000-01-27
IPC分类号： C07C311/29 , C07F9/53 , A61K31/18 , A61K31/664 , A61P19/02
CPC分类号： C07C309/87 , C07C309/42 , C07C311/29 , C07C2601/08 , C07C2601/14
摘要： The invention discloses hydroxamide acids of formula (B) which are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss. In the above formula, the dotted line represents an optional double bond, and R5, R6, R7, R8, R11, R12, X, Y and Z have the meanings given in the specification.
摘要翻译： 本发明公开了式（B）的羟基酰胺酸，其可用于治疗由TNF-α介导的疾病状态，例如类风湿性关节炎，骨关节炎，败血症，AIDS，溃疡性结肠炎，多发性硬化，克罗恩病和退行性软骨损失。 在上式中，虚线表示任选的双键，R5，R6，R7，R8，R11，R12，X，Y和Z具有说明书中给出的含义。
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10.发明公开ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS 有权炔ALPHA-氨基酸基于磺酰胺异羟肟AS TACE抑制剂
公开(公告)号：EP1144368A2
公开(公告)日：2001-10-17
申请号：EP00905750.6
申请日：2000-01-27
IPC分类号： C07C311/00
CPC分类号： C07D207/27 , C07C311/29 , C07C311/39 , C07C311/47 , C07C311/64 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D207/16 , C07D209/20 , C07D211/66 , C07D213/32 , C07D213/42 , C07D213/70 , C07D213/71 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D235/06 , C07D241/04 , C07D243/08 , C07D249/08 , C07D261/18 , C07D265/30 , C07D277/06 , C07D277/24 , C07D279/12 , C07D279/14 , C07D279/16 , C07D281/06 , C07D295/088 , C07D295/125 , C07D295/13 , C07D401/06 , C07D409/06 , C07D513/10
摘要： Compound of the formula (B) are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
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