公开(公告)号：EP2181190B1

公开(公告)日：2014-01-08

申请号：EP08796592.7

申请日：2008-07-25

申请人： Amgen, Inc

发明人： ZHOU, Mingyue ,  BOONE, Thomas ,  MEININGER, David, Park ,  SCHWARTZ, Margrit ,  SHAN, Bei ,  SHEN, Wenyan

IPC分类号： C12N9/10 ,  A61K38/45

CPC分类号： C12N9/1029 ,  A61K47/68 ,  C12Y203/01043

公开(公告)号：EP1891101B1

公开(公告)日：2013-05-22

申请号：EP06751903.3

申请日：2006-04-28

申请人： UCB Pharma, S.A. ,  AMGEN INC.

发明人： PASZTY, Christopher ,  ROBINSON, Martyn, Kim ,  GRAHAM, Kevin ,  HENRY, Alistair, James ,  HOFFMANN, Kelly, Sue ,  LATHAM, John ,  LAWSON, Alastair ,  LU, Hsieng, Sen ,  POPPLEWELL, Andy ,  SHEN, Wenyan ,  WINKLER, David ,  WINTERS, Aaron, George

IPC分类号： C07K14/51 ,  C07K16/18

CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/60 ,  A61K2039/505 ,  C07K14/76 ,  C07K14/79 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

公开(公告)号：EP1915398A2

公开(公告)日：2008-04-30

申请号：EP06787719.1

申请日：2006-07-18

申请人： AMGEN INC. ,  MEDAREX, INC.

发明人： SIU, Gerald ,  SHEN, Wenyan ,  YOSHINAGA, Steven, Kiyoshi ,  HUANG, Haichun

IPC分类号： C07K16/28 ,  A61P37/00 ,  A61P11/06 ,  A61K39/395 ,  G01N33/68 ,  G01N33/577 ,  C12N15/13 ,  C12N5/10

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2827 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPl antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPl antibodies are also provided.

摘要翻译： 本发明提供了与人B7相关蛋白-1（B7RP1）相互作用或与之结合的抗体以及结合并中和B7RP1功能的抗体。 本发明还提供了所述抗体的药物组合物和中和B7RP1功能的方法，特别是通过施用药学有效量的抗B7RPI抗体来治疗免疫疾病（例如，不适当的免疫应答）。 还提供了使用抗B7RPI抗体检测样品中B7RP1的量的方法。

公开(公告)号：EP1692174A2

公开(公告)日：2006-08-23

申请号：EP04810550.6

申请日：2004-11-04

申请人： AMGEN INC.

发明人： ALDRICH, Teri ,  SHEN, Wenyan ,  JACOBSEN, Frederick, W. ,  MORRIS, Arvia, E. ,  ALLEN, Martin, J.

IPC分类号： C07K16/00 ,  C07K16/46 ,  C12N15/13 ,  C12N15/63 ,  C12N5/10

CPC分类号： C07K16/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56

摘要： Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain constant regions derived from cynomolgus monkeys. Chimeric antibodies with cynomolgus monkey constant regions are described.

摘要翻译： 编码的核苷酸序列和包含来源于食蟹猴的重链和轻链恒定区的氨基酸序列。 描述了具有食蟹猴恒定区的嵌合抗体。

公开(公告)号：EP4248976A2

公开(公告)日：2023-09-27

申请号：EP23173456.7

申请日：2008-08-22

申请人： Amgen Inc.

发明人： JACKSON, Simon Mark ,  WALKER, Nigel Pelham, Clinton ,  PIPER, Derek Evan ,  SHAN, Bei ,  SHEN, Wenyan ,  CHAN, Joyce Chi, Yee ,  KING, Chadwick Terence ,  KETCHEM, Randal Robert ,  MEHLIN, Christopher ,  CARABEO, Teresa Arazas ,  CAO, Quiong

IPC分类号： A61K31/66

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：EP2015776A1

公开(公告)日：2009-01-21

申请号：EP07761070.7

申请日：2007-04-20

申请人： Amgen Inc.

发明人： SHEN, Wenyan ,  GRAHAM, Kevin ,  WINTERS, Katherine, Ann ,  VENIANT-ELLISON, Murielle ,  BOONE, Thomas, Charles

IPC分类号： A61K39/395 ,  C07K14/605 ,  C07K16/26

CPC分类号： C07K16/26 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30

摘要： Compositions comprising antibodies that bind glucagon linked to GLP-I compounds are provided, as well as methods of using the compositions for treating, for example, metabolic disorders, enhancing insulin expression, and promoting insulin secretion in a subject.

公开(公告)号：EP1891101A2

公开(公告)日：2008-02-27

申请号：EP06751903.3

申请日：2006-04-28

申请人： UCB Pharma, S.A. ,  AMGEN INC.

发明人： PASZTY, Christopher ,  ROBINSON, Martyn, Kim ,  GRAHAM, Kevin ,  HENRY, Alistair, James ,  HOFFMANN, Kelly, Sue ,  LATHAM, John ,  LAWSON, Alastair ,  LU, Hsieng, Sen ,  POPPLEWELL, Andy ,  SHEN, Wenyan ,  WINKLER, David ,  WINTERS, Aaron, George

IPC分类号： C07K14/51 ,  C07K16/18

CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/60 ,  A61K2039/505 ,  C07K14/76 ,  C07K14/79 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.

摘要翻译： 提供了与硬骨素蛋白的表位和硬骨素结合剂相关的组合物和方法，例如能够结合硬骨素的抗体。

公开(公告)号：EP1841455A1

公开(公告)日：2007-10-10

申请号：EP06719209.6

申请日：2006-01-23

申请人： Amgen Inc.

发明人： SHEN, Wenyan ,  BIERE-CITRON, Anja, Leona

IPC分类号： A61K39/395 ,  C07K16/46 ,  A61P25/28

CPC分类号： C07K16/18 ,  A01K2267/0312 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/77 ,  C07K2317/92

摘要： Compositions for treating neurodegenerative or amyloidgenic disorders such as Alzheimer's disease (AD) are provided. More particularly, humanized anti-amyloid-beta antibodies, compositions containing such antibodies, corresponding nucleic acids, vectors and host cells, and methods of making such antibodies are provided.

公开(公告)号：EP1786837A2

公开(公告)日：2007-05-23

申请号：EP05807469.1

申请日：2005-08-04

申请人： Amgen Inc.,

发明人： LI, Ji ,  SHEN, Wenyan ,  LU, Hsieng Sen ,  RICHARDS, William Gleason

IPC分类号： C07K16/18 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

公开(公告)号：EP3453724A1

公开(公告)日：2019-03-13

申请号：EP18181319.7

申请日：2007-04-24

申请人： Amgen Inc.

发明人： NG, Gordon ,  SHEN, Wenyan

IPC分类号： C07K16/28 ,  C07K16/32 ,  A61K39/395

摘要： This invention relates to compositions and methods for treating c-Kit associated disorders such as fibrosis, and more particularly, to compositions containing humanized c-Kit antibodies.