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1.发明公开DESIGN OF STABLE AND AGGREGATION FREE ANTIBODY FC MOLECULES THROUGH CH3 DOMAIN INTERFACE ENGINEERING 审中-公开设计稳重和聚集游离抗体FC模块，按照CH3结构域的界面设计
公开(公告)号：EP2451840A1
公开(公告)日：2012-05-16
申请号：EP10797631.8
申请日：2010-06-29
申请人： Amgen Inc.
CPC分类号： A61K39/39591 , C07K2317/52
摘要： The present invention relates to methods of increasing stability and reducing aggregation in compositions comprising antibody Fc molecules and to composition comprising such molecules. Certain amino acid substitutions in the CH3 domain result in increased stability and reduced aggregation of compositions containing polypeptides comprising a CH3 domain, e.g., an antibody or Fc-fusion protein.
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公开(公告)号：EP1699825A2
公开(公告)日：2006-09-13
申请号：EP04815058.5
申请日：2004-12-21
申请人： Amgen, Inc.
发明人： YAN, Wei , SHEN, Wenyan , ZHOU, Hongxing , ZHOU, Chen , COSMAN, David, J , CARTER, Paul , MARTIN, Francis, H
CPC分类号： C07K16/005 , C07K16/2863 , C07K16/2866 , C07K16/2875 , C07K16/2878 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/80 , C07K2319/00 , C12N15/1037 , G01N33/6854
摘要： The invention provides methods for screening multimeric antibodies produced by mammalian cells to find those that exhibit a biological function. The methods can be used to screen large numbers of antibodies, which may be cell surface, secreted, or intracellular antibodies. Antibodies can be screened to find those that bind antigen more avidly or those that compete with a ligand that binds to the antigen for binding. Any biological function that can be tested in vitro can be used to screen the antibodies. Nucleic acids encoding the antibodies that exhibit the biological function can be obtained in a number of ways.
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公开(公告)号：EP2504360B1
公开(公告)日：2018-08-15
申请号：EP10832331.2
申请日：2010-11-22
申请人： Amgen Inc.
发明人： ZHOU, Hongxing , KANNAN, Gunasekaran , SUN, Nancy
CPC分类号： C07K16/00 , C07K2317/52
摘要： The invention relates to monomeric Fc polypeptides and methods of making and using such polypeptides. The polypeptides comprise substitution of one or more hydrophobic interface residues in the CH3 region with a polar amino acid.
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公开(公告)号：EP2007812A2
公开(公告)日：2008-12-31
申请号：EP07755338.6
申请日：2007-04-13
申请人： Amgen Inc.
IPC分类号： C07K16/28 , A61K39/395 , A61P7/06
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/92
摘要： Antibodies that bind erythropoietin receptor are provided. Methods of making and using such antibodies are also provided. Kits containing such antibodies are also provided.
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5.发明授权
公开(公告)号：EP2451840B1
公开(公告)日：2018-12-26
申请号：EP10797631.8
申请日：2010-06-29
申请人： Amgen Inc.
CPC分类号： A61K39/39591 , C07K2317/52
摘要： The present invention relates to methods of increasing stability and reducing aggregation in compositions comprising antibody Fc molecules and to composition comprising such molecules. Certain amino acid substitutions in the CH3 domain result in increased stability and reduced aggregation of compositions containing polypeptides comprising a CH3 domain, e.g., an antibody or Fc-fusion protein.
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公开(公告)号：EP2596114A2
公开(公告)日：2013-05-29
申请号：EP11807516.7
申请日：2011-07-14
申请人： Amgen, Inc
发明人： ZHOU, Hongxing
CPC分类号： C07K16/468 , C07K16/244 , C07K16/2878
摘要： Described herein is an antibody format, which is amenable to bispecific antibody creation. This format is referred to herein as "Domain Insertion Immunoglobulin G" or "(Di-IgG)". The Di-IgG molecules are capable of specifically binding two different antigens simultaneously, show high level recombinant expression, and are sufficiently aggregation-free to be amenable to commercial production. Further described herein are, Di-IgG-encoding nucleic acids and vectors, host cells for making Di-IgGs, Di-IgG pharmaceutical compositions, and methods of treatment.
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公开(公告)号：EP2504360A1
公开(公告)日：2012-10-03
申请号：EP10832331.2
申请日：2010-11-22
申请人： Amgen Inc.
发明人： ZHOU, Hongxing , KANNAN, Gunasekaran , SUN, Nancy
CPC分类号： C07K16/00 , C07K2317/52
摘要： The invention relates to monomeric Fc polypeptides and methods of making and using such polypeptides. The polypeptides comprise substitution of one or more hydrophobic interface residues in the CH3 region with a polar amino acid.
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公开(公告)号：EP2421897A1
公开(公告)日：2012-02-29
申请号：EP10715636.6
申请日：2010-04-21
申请人： Amgen Inc.
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , C07K2317/52 , C07K2317/53 , C07K2319/30
摘要： The present invention provides compositions and methods relating to human IgG1 and IgG3 Fc-conjugates which are resistant to free-radical mediated fragmentation and aggregation. The present invention also provides compositions and methods for making the Fc-conjugates of the invention.
摘要翻译： 本发明提供了涉及抗自由基介导的断裂和聚集的人IgG1和IgG3 Fc-缀合物的组合物和方法。 本发明还提供用于制备本发明的Fc-缀合物的组合物和方法。
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