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    SULFITE-BASED PROCESSES FOR PRODUCING NANOCELLULOSE, AND COMPOSITIONS AND PRODUCTS PRODUCED THEREFROM
    3.
    发明公开
    SULFITE-BASED PROCESSES FOR PRODUCING NANOCELLULOSE, AND COMPOSITIONS AND PRODUCTS PRODUCED THEREFROM 审中-公开
    生产纳米纤维的亚硫酸盐工艺，以及由此生产的组合物和产品

    公开(公告)号：EP3089998A2

    公开(公告)日：2016-11-09

    申请号：EP14877397.1

    申请日：2014-12-30

    申请人： Api Intellectual Property Holdings, LLC

    发明人： NELSON, Kimberly ,  RETSINA, Theodora ,  PYLKKANEN, Vesa ,  O'CONNOR, Ryan

    IPC分类号： C08B15/00 ,  C08B15/08 ,  C08B1/00 ,  C08H8/00 ,  B82B3/00

    CPC分类号： D21H11/18 ,  C13K1/02 ,  D21C3/04 ,  D21C3/06 ,  D21C9/007 ,  D21C9/10 ,  D21H11/06 ,  D21H17/66 ,  D21H21/32

    摘要： Processes disclosed are capable of converting biomass into high-crystallinity nanocellulose with low mechanical energy input. In some variations, the process includes fractionating biomass with sulfur dioxide or a sulfite compound and water, to generate cellulose-rich solids and a liquid containing hemicellulose and lignin; and mechanically treating the cellulose-rich solids to form nanofibrils and/or nanocrystals. The total mechanical energy may be less than 500 kilowatt-hours per ton. The crystallinity of the nanocellulose material may be 80% or higher, translating into good reinforcing properties for composites. The nanocellulose material may include nanofibrillated cellulose, nanocrystalline cellulose, or both. In some embodiments, the nanocellulose material is hydrophobic via deposition of some lignin onto the cellulose surface. Optionally, sugars derived from amorphous cellulose and hemicellulose may be separately fermented, such as to monomers for various polymers. These polymers may be combined with the nanocellulose to form completely renewable composites.

    摘要翻译： 所公开的工艺能够将生物质转化为具有低机械能输入的高结晶度纳米纤维素。 在一些变型中，该方法包括用二氧化硫或亚硫酸盐化合物和水分馏生物质以产生富含纤维素的固体和含有半纤维素和木质素的液体; 并机械处理富含纤维素的固体以形成纳米纤丝和/或纳米晶体。 总的机械能可能低于每千克500千瓦小时。 纳米纤维素材料的结晶度可以为80％或更高，转化为复合材料的良好增强性能。 纳米纤维素材料可以包括纳米纤维素纤维素，纳米晶体纤维素或两者。 在一些实施方案中，纳米纤维素材料通过将一些木质素沉积到纤维素表面上而是疏水的。 任选地，衍生自无定形纤维素和半纤维素的糖可以分开发酵，例如用于各种聚合物的单体。 这些聚合物可以与纳米纤维素结合以形成完全可再生的复合材料。

    PROCESSES AND APPARATUS FOR LIGNIN SEPARATION IN BIOREFINERIES
    6.
    发明公开
    PROCESSES AND APPARATUS FOR LIGNIN SEPARATION IN BIOREFINERIES 审中-公开
    在生物炼制的方法和装置LIGNINABSCHEIDUNG

    公开(公告)号：EP2880173A1

    公开(公告)日：2015-06-10

    申请号：EP13827637.3

    申请日：2013-08-06

    申请人： API Intellectual Property Holdings, LLC.

    发明人： RETSINA, Theodora ,  PYLKKANEN, Vesa ,  NELSON, Kimberly ,  SZCZEPANIK, Mark

    IPC分类号： C12P19/02 ,  C08B1/00 ,  C08H7/00

    CPC分类号： C08B1/00 ,  C08B37/0057 ,  C08H6/00 ,  C08H8/00

    摘要： The present invention generally provides methods of improving lignin separation during lignocellulosic biorefining, comprising the steps of (i) catalyzing fractionation or hydrolysis with an acid to release sugars into an acidified solution containing lignin, (ii) neutralizing the acidified solution with a base to form a salt in a neutralized solution; (iii) in a separation unit, separating the salt and the lignin, each in free or combined form, from the neutralized solution; and then (iv) recycling a portion of the salt and optionally a portion of the lignin to step (i) to combine, physically or chemically, with the lignin, to improve lignin separation in the separation unit. In certain embodiments, the acid is a sulfur-containing acid and the base is lime, forming gypsum which is then recycled, in part, to the hydrolysis reactor.

    PROCESSES FOR PRODUCING PHARMACEUTICAL EXCIPIENTS FROM LIGNOCELLULOSIC BIOMASS, AND PHARMACEUTICAL EXCIPIENTS OBTAINED THEREFROM
    9.
    发明公开
    PROCESSES FOR PRODUCING PHARMACEUTICAL EXCIPIENTS FROM LIGNOCELLULOSIC BIOMASS, AND PHARMACEUTICAL EXCIPIENTS OBTAINED THEREFROM 审中-公开
    从木质纤维素生物质生产药物赋形剂的过程以及由此获得的药物赋形剂

    公开(公告)号：EP3240532A1

    公开(公告)日：2017-11-08

    申请号：EP15876129.6

    申请日：2015-12-29

    申请人： Api Intellectual Property Holdings, LLC

    发明人： NELSON, Kimberly ,  RETSINA, Theodora ,  PYLKKANEN, Vesa

    IPC分类号： A61K9/20 ,  C08B15/08 ,  A61K47/38

    CPC分类号： A61K47/38 ,  C08B37/0057 ,  C08H6/00 ,  C08H8/00

    摘要： In some variations, the invention provides a process for producing a microcrystalline cellulose material, comprising: fractionating lignocellulosic biomass feedstock in the presence of an acid, a solvent for lignin, and water, to generate cellulose-rich solids and a liquid containing hemicellulose and lignin; chemically and/or mechanically treating the cellulose-rich solids to form microcrystalline cellulose having an average crystallinity of at least 60%; and recovering the microcrystalline cellulose as a pharmaceutical excipient. The pharmaceutical excipient may function as an antiadherent, a binder, a coating, or a disintegrant. In some embodiments, the pharmaceutical excipient further comprises a lignin-derived lubricant, glidant, sorbent, preservative, or other component. The pharmaceutical excipient may be present in a pill, tablet, capsule, powder, slurry, or other pharmaceutically effective and acceptable form.

    PRODUCTION OF SUGARS AND CO-PRODUCTS FROM CELLULOSIC WASTE STREAMS
    10.
    发明公开
    PRODUCTION OF SUGARS AND CO-PRODUCTS FROM CELLULOSIC WASTE STREAMS 审中-公开
    糖生产和副产品从纤维素废物流

    公开(公告)号：EP3011042A2

    公开(公告)日：2016-04-27

    申请号：EP14813251.7

    申请日：2014-06-17

    申请人： API Intellectual Property Holdings, LLC.

    发明人： RETSINA, Theodora ,  NELSON, Kimberly

    IPC分类号： C12P19/02 ,  C12P7/02

    CPC分类号： C13K1/02 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14

    摘要： This disclosure provides a business method and system for generating sugars and recycling a non-biomass component from a waste stream. In some embodiments, a waste stream comprising cellulose and a non-biomass component is saccharified to produce glucose, followed by recovery of the glucose and non-biomass component, which may be recycled to another site associated with production of a cellulose-containing product that contains the non-biomass component. In certain scenarios, the waste stream is generated at a first location, cellulose pretreatment (if desired) and hydrolysis are conducted at a second location, and the non-biomass component is recycled to the first location or a third location. The non-biomass component may include metals, metal oxides, salts, organic compounds, inorganic compounds, oligomers, or polymers, for example.