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公开(公告)号：EP1015844A1
公开(公告)日：2000-07-05
申请号：EP98910346.0
申请日：1998-03-16
Applicant: Applied Spectral Imaging Ltd.
Inventor： CABIB, Dario , BUCKWALD, Robert, A. , MALIK, Zvi , BEN-YOSEF, Nissim
IPC: G01B9/02
CPC classification number: C12Q1/6816 , C12Q1/6841 , C12Q1/6883 , G01J3/02 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J5/10 , G01J2003/2866 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N33/56966 , G01N33/582 , G01N2021/6417 , G06K9/00127 , G06K9/76
Abstract: According to the present invention there is provided a spectral bio-imaging methods which can be used for automatic and/or semiautomatic spectrally resolved morphometric classification of cells, the method comprising the steps of (a) preparing a sample to be spectrally imaged, the sample including at least a portion of at least one cell; (b) viewing the sample through an optical device, the optical device being optically connected to an imaging spectrometer, the optical device and the imagine spectrometer being for obtaining a spectrum of each pixel of the sample; (c) classifying each of the pixels into classification groups according to the pixels spectra; and (d) analyzing the classification groups and thereby classifying the at least one cell into a cell class.
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公开(公告)号：EP1131631B1
公开(公告)日：2009-01-07
申请号：EP99963904.0
申请日：1999-11-16
Applicant: Applied Spectral Imaging Ltd.
Inventor： GARINI, Yuval , MCNAMARA, George , SOENKSEN, Dirk, G. , CABIB, Dario , BUCKWALD, Robert, A.
CPC classification number: C12Q1/6841 , C12Q1/6883 , G01J3/02 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J2003/2866 , G01N1/30 , G01N21/6428 , G01N21/6456 , G01N33/5005 , G01N33/53 , G01N33/56966 , G01N33/582 , G01N2021/6423 , G01N2021/6441 , G06K9/00127 , G06K9/76 , Y10S435/968
Abstract: A method of in situ analysis of a biological sample comprising the steps of (a) staining the biological sample with N stains of which a first stain is selected from the group consisting of a first immunohistochemical stain, a first histological stain and a first DNA ploidy stain, and a second stain is selected from the group consisting of a second immunohistochemical stain, a second histological stain and a second DNA ploidy stain, with provisions that N is an integer greater than three and further that (i) if the first stain is the first immunohistochemical stain then the second stain is either the second histological stain or the second DNA ploidy stain; (ii) if the first stain is the first histological stain then the second stain is either the second immunohistochemical stain or the second DNA ploidy stain; whereas (iii) if the first stain is the first DNA ploidy stain then the second stain is either the second immunohistochemical stain or the second histological stain; and (b) using a spectral data collection device for collecting spectral data from the biological sample, the spectral data collection device and the N stains are selected so that a spectral component associated with each of the N stains is collectible. Figure (1) shows a block diagram illustrating the main components of an imaging spectrometer.
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3.发明公开SPECTRAL BIO-IMAGING DATA FOR CELL CLASSIFICATION USING INTERNAL REFERENCE 审中-公开生物SPEKTRALBILDUNGSDATEN与内部参考分类
公开(公告)号：EP1114393A1
公开(公告)日：2001-07-11
申请号：EP99946816.8
申请日：1999-09-10
Applicant: Applied Spectral Imaging Ltd.
Inventor： CABIB, Dario , BUCKWALD, Robert, A. , BEN-YOSEF, Nissim
IPC: G06K9/00
CPC classification number: G01B11/0675 , G01J3/02 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J5/10 , G01J2003/2866 , G01N1/30 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N33/56966 , G01N33/582 , G01N2021/6417 , G06K9/00127 , G06K9/76
Abstract: A method of spectral-morphometric analysis of biological samples, the biological samples including substantially constant components and suspected variable components, the method is effected by the following the steps of (a) using a spectral data collection device for collecting spectral data of picture elements of the biological samples; (b) defining a spectral vector associated with picture elements representing a constant component of at least one of the biological samples; (c) using said spectral vector for defining a correcting function being selected such that when operated on spectral vectors associated with picture elements representing other constant components, spectral vectors of said other constant components are modified to substantially resemble said spectral vector; (d) operating said correcting function on spectral associated with at least the variable components for obtaining corrected spectral vectors thereof; and (e) classifying said corrected spectral vectors into classification groups.
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公开(公告)号：EP1107688A1
公开(公告)日：2001-06-20
申请号：EP99940981.6
申请日：1999-08-16
Applicant: Applied Spectral Imaging Ltd.
Inventor： ADEL, Michael, E. , CABIB, Dario , WINE, David
IPC: A61B3/10
CPC classification number: A61B3/10 , G01J3/10 , G01J3/2823 , G01J2003/1282
Abstract: This invention is a device, and method for spectral imaging of an object. A plurality of sets of narrow-band light sources (12) such as LEDs are provided. Each set emits illumination radiation in a different narrow spectral band. Each set is activated sequentially to illuminate the object (16). Light reflected from the object or transmitted by the object is focused (26) on a detector array (20) to image the object. Narrower illumination bands are provided by dispersing the emitted light using a dispersive optical element such as a diffraction grating. Alternatively, selected sets or subsets are activated simultaneously with duty cycles that emulate a preselected spectral distribution. For imaging ocular fundus tissue, the illumination light is shaped into an annular beam by an appropriately shaped wave-guide.
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公开(公告)号：EP1100965A1
公开(公告)日：2001-05-23
申请号：EP99935850.0
申请日：1999-07-23
Applicant: Applied Spectral Imaging Ltd.
Inventor： BAR-AM, Irit , JANISH, Cathy , GARINI, Yuval , CABIB, Dario , BUCKWALD, Robert, A.
CPC classification number: C12Q1/6841 , C12Q2527/125 , C12Q2563/107 , C12Q2527/101 , C12Q2525/151
Abstract: A fluorescent in situ hybridization method including the steps of (a) obtaining a chromosome spread of a species; (b) preparing a hybridization composite containing a plurality of chromosomal paints each of the plurality of chromosomal paints being labeled with a different fluorophore-or-combination-of-fluorophores, such that an averaged specific activity of highly repetitive sequences in the hybridization composite substantially equals an averaged specific activity of unique sequences in the hybridization composite; (c) denaturing the hybridization composite and subjecting the hybridization composite to conditions for allowing at least a part of the highly repetitive sequences in the hybridization composite to reanneal while at least a part of the unique sequences in the hybridization composite remaining single stranded; (d) contacting under hybridization conditions the hybridization composite with the chromosome spread; (e) washing away excess of the hybridization composite; and (f) analyzing and presenting images of the now hybridized chromosome spread.
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Patent Agency Ranking
公开(公告)号：EP1182960A1
公开(公告)日：2002-03-06
申请号：EP00922829.7
申请日：2000-05-03
Applicant: Applied Spectral Imaging Ltd.
Inventor： GIL, Tamir , CABIB, Dario , ADEL, Michael , BUCKWALD, Robert, A. , HORN, Eli
IPC: A61B3/14
CPC classification number: G06T5/50 , A61B3/10 , A61B5/0059 , A61B5/0066 , A61B5/0275 , A61B5/14546 , A61B5/1455 , A61B5/14555 , A61B5/411 , A61B5/7257 , G01J3/2823 , G01J3/4406 , G01J3/462 , G01J3/50 , G01J3/502 , G01J3/51 , G01J2003/467 , G06T7/90 , G06T11/001 , G06T2207/10152 , G06T2207/30041
Abstract: A spectral bio-imaging method for enhancing pathologic, physiologic, metabolic and health related spectral signatures of an eye tissue, the method comprising the steps of: (a) providing an optical device for eye inspection being optically connected to a spectral imager; (b) illuminating the eye tissue with light via the iris, viewing the eye tissue through the optical device and spectral imager and obtaining a spectrum of light for each pixel of the eye tissue; and (c) attributing each of the pixels a color or intensity according to its spectral signature, thereby providing an image enhancing the spectral signatures of the eye tissue.
Abstract translation: 一种用于增强眼组织的病理，生理，代谢和健康相关光谱特征的光谱生物成像方法，所述方法包括以下步骤：（a）提供用于眼睛检查的光学装置，光学连接到光谱成像器; （b）通过光圈照射眼组织，通过光学装置和光谱成像仪观察眼组织，并为眼组织的每个像素获得光谱; 和（c）根据其光谱特征将每个像素归为颜色或强度，由此提供增强眼组织的光谱特征的图像。
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7.发明公开METHOD FOR CHROMOSOME CLASSIFICATION BY DECORRELATION STATISTICAL ANALYSIS AND HARDWARE THEREFORE 失效如通过用于解相关统计分析和硬件的装置，用于染色体分类的方法
公开(公告)号：EP0935679A1
公开(公告)日：1999-08-18
申请号：EP97945247.0
申请日：1997-09-19
Applicant: Applied Spectral Imaging Ltd.
Inventor： CABIB, Dario , BUCKWALD, Robert, A. , BEN-YOSEF, Nissim
CPC classification number: C12Q1/6816 , C12Q1/6841 , C12Q1/6883 , G01J3/02 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J3/457 , G01J2003/2866 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N33/56966 , G01N2021/6423 , G01N2021/6441 , G01N2021/6471 , G06K9/00127 , G06K9/76
Abstract: A method and hardware for chromosome classification by decorrelation statistical analysis to provide color (spectral) karyotypes and to detect chromosomal aberrations.
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8.发明授权METHOD FOR REMOTE SENSING ANALYSIS BY DECORRELATION STATISTICAL ANALYSIS AND HARDWARE THEREFOR 失效方法和设备进行远程监控分析统计分析GRAPHIC关系
公开(公告)号：EP1008098B1
公开(公告)日：2003-04-09
申请号：EP98931721.9
申请日：1998-06-29
Applicant: Applied Spectral Imaging Ltd.
Inventor： CABIB, Dario
CPC classification number: G01J3/12 , G01J3/02 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J2003/2866 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N33/56966 , G01N33/582 , G06K9/00127 , G06K9/00201 , G06K9/0063 , G06K9/76
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公开(公告)号：EP1131631A1
公开(公告)日：2001-09-12
申请号：EP99963904.0
申请日：1999-11-16
Applicant: Applied Spectral Imaging Ltd.
Inventor： GARINI, Yuval , MCNAMARA, George , SOENKSEN, Dirk, G. , CABIB, Dario , BUCKWALD, Robert, A.
CPC classification number: C12Q1/6841 , C12Q1/6883 , G01J3/02 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J2003/2866 , G01N1/30 , G01N21/6428 , G01N21/6456 , G01N33/5005 , G01N33/53 , G01N33/56966 , G01N33/582 , G01N2021/6423 , G01N2021/6441 , G06K9/00127 , G06K9/76 , Y10S435/968
Abstract: A method of in situ analysis of a biological sample comprising the steps of (a) staining the biological sample with N stains of which a first stain is selected from the group consisting of a first immunohistochemical stain, a first histological stain and a first DNA ploidy stain, and a second stain is selected from the group consisting of a second immunohistochemical stain, a second histological stain and a second DNA ploidy stain, with provisions that N is an integer greater than three and further that (i) if the first stain is the first immunohistochemical stain then the second stain is either the second histological stain or the second DNA ploidy stain; (ii) if the first stain is the first histological stain then the second stain is either the second immunohistochemical stain or the second DNA ploidy stain; whereas (iii) if the first stain is the first DNA ploidy stain then the second stain is either the second immunohistochemical stain or the second histological stain; and (b) using a spectral data collection device for collecting spectral data from the biological sample, the spectral data collection device and the N stains are selected so that a spectral component associated with each of the N stains is collectible. Figure (1) shows a block diagram illustrating the main components of an imaging spectrometer.
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公开(公告)号：EP1026987A1
公开(公告)日：2000-08-16
申请号：EP98949638.5
申请日：1998-09-29
Applicant: Applied Spectral Imaging Ltd.
Inventor： CABIB, Dario , ADEL, Michael , BUCKWALD, Robert, A.
IPC: A61B5/05
CPC classification number: A61B5/14555 , A61B3/10 , A61B5/411 , A61B5/7257 , C12Q1/6816 , C12Q1/6841 , C12Q1/6883 , G01J3/02 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J3/4535 , G01J2003/2866 , G01N21/6428 , G01N21/6456 , G01N21/6458 , G01N33/5005 , G01N33/56966 , G01N33/582 , G01N2021/6417 , G01N2021/6423 , G01N2021/6441 , G06K9/00127 , G06K9/76
Abstract: A spectral bio-imaging method for enhancing pathologic, physiologic, metabolic and health related spectral signatures of an eye tissue, the method comprising the steps of (a) providing an optical device for eye inspection being optically connected to a spectral imager; (b) illuminating the eye tissue with light via the iris, viewing the eye tissue through the optical device and spectral imager and obtaining a spectrum of light for each pixel of the eye tissue; and (c) attributing each of the pixels a color or intensity according to its spectral signature, thereby providing an image enhancing the spectral signatures of the eye tissue.
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