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公开(公告)号：EP3694853A1
公开(公告)日：2020-08-19
申请号：EP18796238.6
申请日：2018-10-10
发明人： EARY, Charles Todd , SPENCER, Stacey , CRANE, Zack , CHANDO, Katelyn , ASSELIN, Sylvie , LIU, Weidong , WELCH, Mike , COOK, Adam , KOLAKOWSKI, Gabrielle R. , METCALF, Andrew T. , MORENO, David A. , TANG, Tony P.
IPC分类号： C07D471/04 , C07D519/00
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公开(公告)号：EP3740491A1
公开(公告)日：2020-11-25
申请号：EP19703907.6
申请日：2019-01-18
发明人： BLAKE, James F. , DAI, Donghua , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , MCFADDIN, Elizabeth A. , MCKENNEY, Megan L. , METCALF, Andrew T. , MORENO, David A. , PRIGARO, Brett , RAMANN, Ginelle A. , REN, Li
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
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公开(公告)号：EP3849986A1
公开(公告)日：2021-07-21
申请号：EP19773595.4
申请日：2019-09-06
发明人： BLAKE, James F. , DAI, Donghua , HAAS, Julia , JIANG, Yutong , KAHN, Dean , KOLAKOWSKI, Gabrielle R. , MCFADDIN, Elizabeth A. , MCKENNEY, Megan L. , METCALF, Andrew T. , MORENO, David A. , PRIGARO, Brett , RAMANN, Ginelle A. , REN, Li , WALLS, Shane M. , ZHANG, Hailong
IPC分类号： C07D487/14 , C07D487/22 , C07D498/14 , C07D498/22 , A61P35/00 , A61K31/551
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公开(公告)号：EP3740486A1
公开(公告)日：2020-11-25
申请号：EP19703912.6
申请日：2019-01-18
发明人： WALLS, Shane M. , REN, Li , RAMANN, Ginelle A. , MORENO, David A. , METCALF, Andrew T. , MCFADDIN, Elizabeth A. , KOLAKOWSKI, Gabrielle R. , BLAKE, James F. , DAI, Donghua , HAAS, Julia , JIANG, Yutong , KAHN, Dean
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
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公开(公告)号：EP2766368A1
公开(公告)日：2014-08-20
申请号：EP12775905.8
申请日：2012-10-09
申请人： Array Biopharma Inc.
发明人： BOYS, Mark Laurence , BURGESS, Laurence E. , EARY, C. Todd , GRONEBERG, Robert , HACHE, Bruno P. , HARVEY, Darren , HICKEN, Erik James , KRASER, Christopher F. , LAIRD, Ellen , MORENO, David A. , MUNSON, Mark C. , REN, Li , ROBINSON, John E. , SCHLACHTER, Stephen T.
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00
CPC分类号： C07D487/04
摘要： Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , X
1 and X
2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，X 1和X 2具有说明书中给出的含义的式I化合物及其立体异构体和药学上可接受的盐和溶剂合物是 一种或多种JAK激酶，并且可用于治疗自身免疫性疾病，炎性疾病，移植器官，组织和细胞的排斥，以及血液病和恶性肿瘤及其并发症。
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公开(公告)号：EP3740490A1
公开(公告)日：2020-11-25
申请号：EP19703591.8
申请日：2019-01-18
发明人： BLAKE, James F. , DAI, Donghua , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI,, Gabrielle R. , METCALF, Andrew T. , MORENO, David A. , PRIGARO, Brett , REN, Li
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
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公开(公告)号：EP2820009B1
公开(公告)日：2018-01-31
申请号：EP13710222.4
申请日：2013-03-01
发明人： BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/6558 , C07F9/6596 , A61K31/435 , A61K31/506 , A61P29/00 , A61P35/00
CPC分类号： C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
摘要： Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：EP3523301B1
公开(公告)日：2020-05-27
申请号：EP17787843.6
申请日：2017-10-10
申请人： Array Biopharma Inc.
发明人： ANDREWS, Steven W. , ARONOW, Sean , BLAKE, James F. , BRANDHUBER, Barbara J. , COOK, Adam , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , MCFADDIN, Elizabeth A. , MCKENNEY, Megan L. , MCNULTY, Oren T. , METCALF, Andrew T. , MORENO, David A. , TANG, Tony P. , REN, Li
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
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公开(公告)号：EP2820009A1
公开(公告)日：2015-01-07
申请号：EP13710222.4
申请日：2013-03-01
发明人： BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/6558 , C07F9/6596 , A61K31/435 , A61K31/506 , A61P29/00 , A61P35/00
CPC分类号： C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
摘要： Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 提供式I化合物或其立体异构体，互变异构体，前药或药学上可接受的盐，其可用于治疗过度增殖性疼痛和炎性疾病。 公开了使用式I化合物或其立体异构体，互变异构体，前药或药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞中的此类病症或相关病理学病症的方法。
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公开(公告)号：EP3898626A1
公开(公告)日：2021-10-27
申请号：EP19836396.2
申请日：2019-12-13
发明人： BLAKE, James F. , MORENO, David A. , REN, Li , TANG, Tony P. , WALLS, Shane M.
IPC分类号： C07D471/04 , C07D519/00 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/4995 , A61P35/00
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