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公开(公告)号：EP1673339B1
公开(公告)日：2013-07-03
申请号：EP04783028.6
申请日：2004-09-01
发明人： WALLACE, Eli , HURLEY, Brian , YANG, Hoon, Woon , LYSSIKATOS, Joseph , MARLOW, Allison, L. , BLAKE, Jim
IPC分类号： A61K31/42 , C07D261/20 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , C07D261/20
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公开(公告)号：EP1682138B1
公开(公告)日：2011-01-12
申请号：EP04811727.9
申请日：2004-11-18
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim
IPC分类号： C07D213/80 , C07D401/06 , C07D413/04 , C07D413/14 , C07D401/04 , C07D417/04 , C07D471/04 , C07D237/24 , A61K31/44 , A61K31/4353 , A61K31/501 , A61K31/5025 , A61P35/00
CPC分类号： C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP1689406A2
公开(公告)日：2006-08-16
申请号：EP04811721.2
申请日：2004-11-18
发明人： WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , HURLEY, T., Brian , BLAKE, Jim , MARLOW, Allison, L.
IPC分类号： A61K31/50 , A61K31/519 , A61K31/44 , C07D403/02 , C07D487/02 , C07D221/04 , C07D471/02
CPC分类号： C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X, Y and Z are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP1682138B3
公开(公告)日：2013-01-09
申请号：EP04811727.9
申请日：2004-11-18
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim
IPC分类号： C07D213/80 , C07D401/06 , C07D413/04 , C07D413/14 , C07D401/04 , C07D417/04 , C07D471/04 , C07D237/24 , A61K31/44 , A61K31/4353 , A61K31/501 , A61K31/5025 , A61P35/00
CPC分类号： C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
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公开(公告)号：EP1922307A2
公开(公告)日：2008-05-21
申请号：EP06836069.2
申请日：2006-05-17
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim , STOREY, Richard, Anthony , BOOTH, Rebecca, Jane , PITTAM, John, David , LEONARD, John , FIELDING, Mark, Richard
IPC分类号： C07D213/84 , C07D213/63 , A61K31/44
CPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
摘要： Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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6.发明公开SERINE/THREONINE KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE!DISEASES 审中-公开丝氨酸/苏氨酸激酶抑制剂治疗过度增生！ 疾病
公开(公告)号：EP2888247A1
公开(公告)日：2015-07-01
申请号：EP13759395.0
申请日：2013-08-27
发明人： BLAKE, Jim , CHEN, Huifen , CHICARELLI, Mark , GAUDINO, John , GAZZARD, Lewis , KINTZ, Sam , MOHR, Pete , ROBARGE, Kirk , SCHWARZ, Jacob , ZHOU, Aihe
IPC分类号： C07D401/14 , C07D401/12 , C07D471/04 , C07D217/22 , A61P35/00 , A61K31/4375 , A61K31/4725 , A61K31/472
摘要： Compounds having the formula I wherein R2, X and Z as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
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公开(公告)号：EP1689233B1
公开(公告)日：2012-07-04
申请号：EP04811728.7
申请日：2004-11-18
发明人： WALLACE, Eli , YANG, Hong, Woon , BLAKE, Jim
IPC分类号： C07D209/46 , A01N43/64 , A01N43/58 , A01N43/60 , A01N43/54 , A01N43/90 , A01N43/42 , A01N33/02 , A61K31/53 , A61K31/495 , A61K31/50 , A61K31/517 , A61P35/00 , C07D237/32 , C07D231/56
CPC分类号： C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R8, R9 and R10, W, X, and Z are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP1922307B1
公开(公告)日：2011-12-28
申请号：EP06836069.2
申请日：2006-05-17
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim , STOREY, Richard, Anthony , BOOTH, Rebecca, Jane , PITTAM, John, David , LEONARD, John , FIELDING, Mark, Richard
IPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/85 , A61K31/501 , A61P35/00
CPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
摘要： Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP2888247B1
公开(公告)日：2020-03-25
申请号：EP13759395.0
申请日：2013-08-27
发明人： BLAKE, Jim , CHEN, Huifen , CHICARELLI, Mark , GAUDINO, John , GAZZARD, Lewis , KINTZ, Sam , MOHR, Pete , ROBARGE, Kirk , SCHWARZ, Jacob , ZHOU, Aihe
IPC分类号： C07D401/14 , C07D401/12 , C07D471/04 , C07D217/22 , A61P35/00 , A61K31/4375 , A61K31/4725 , A61K31/472
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公开(公告)号：EP1689233A2
公开(公告)日：2006-08-16
申请号：EP04811728.7
申请日：2004-11-18
发明人： WALLACE, Eli , YANG, Hong, Woon , BLAKE, Jim
IPC分类号： A01N43/64 , A01N43/58 , A01N43/60 , A01N43/54 , A01N43/90 , A01N43/42 , A01N33/02 , A61K31/53 , A61K31/495 , A61K31/50 , A61K31/517 , A61K31/519
CPC分类号： C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R8, R9 and R10, W, X, and Z are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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