-
公开(公告)号：EP1682138B3
公开(公告)日：2013-01-09
申请号：EP04811727.9
申请日：2004-11-18
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim
IPC分类号： C07D213/80 , C07D401/06 , C07D413/04 , C07D413/14 , C07D401/04 , C07D417/04 , C07D471/04 , C07D237/24 , A61K31/44 , A61K31/4353 , A61K31/501 , A61K31/5025 , A61P35/00
CPC分类号： C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
-
公开(公告)号：EP1922307A2
公开(公告)日：2008-05-21
申请号：EP06836069.2
申请日：2006-05-17
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim , STOREY, Richard, Anthony , BOOTH, Rebecca, Jane , PITTAM, John, David , LEONARD, John , FIELDING, Mark, Richard
IPC分类号： C07D213/84 , C07D213/63 , A61K31/44
CPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
摘要： Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
-
公开(公告)号：EP1682138A2
公开(公告)日：2006-07-26
申请号：EP04811727.9
申请日：2004-11-18
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim
IPC分类号： A61K31/44 , A61K31/50 , A61K31/415 , A61K31/501 , A61K31/655 , C07D231/02 , C07D237/02 , C07D401/00 , C07D413/00 , C07D417/00
CPC分类号： C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
-
公开(公告)号：EP1673339A2
公开(公告)日：2006-06-28
申请号：EP04783028.6
申请日：2004-09-01
发明人： WALLACE, Eli , HURLEY, Brian , YANG, Hoon, Woon , LYSSIKATOS, Joseph , MARLOW, Allison, L. , BLAKE, Jim
IPC分类号： C07D201/00
CPC分类号： C07D471/04 , C07D261/20
摘要： Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 and R10, W and Y are defined in the specification. Such compounds are MEK inhibitors and useful in the treament of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative disease in mammals and pharmaceutical compositons conataining such compounds.
摘要翻译： 公开了式（I）化合物及其药学上可接受的盐和前药，其中R 1，R 2，R 7，R 8，R 9和R 10，W和Y在说明书中定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增殖性疾病，如癌症和炎症。 还公开了使用此类化合物治疗哺乳动物和含有这些化合物的药物组合物中过度增殖性疾病的方法。
-
公开(公告)号：EP1682138B1
公开(公告)日：2011-01-12
申请号：EP04811727.9
申请日：2004-11-18
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim
IPC分类号： C07D213/80 , C07D401/06 , C07D413/04 , C07D413/14 , C07D401/04 , C07D417/04 , C07D471/04 , C07D237/24 , A61K31/44 , A61K31/4353 , A61K31/501 , A61K31/5025 , A61P35/00
CPC分类号： C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
-
公开(公告)号：EP1689406A2
公开(公告)日：2006-08-16
申请号：EP04811721.2
申请日：2004-11-18
发明人： WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , HURLEY, T., Brian , BLAKE, Jim , MARLOW, Allison, L.
IPC分类号： A61K31/50 , A61K31/519 , A61K31/44 , C07D403/02 , C07D487/02 , C07D221/04 , C07D471/02
CPC分类号： C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X, Y and Z are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
-
公开(公告)号：EP1482932A1
公开(公告)日：2004-12-08
申请号：EP03714148.8
申请日：2003-03-13
IPC分类号： A61K31/4184 , C07D235/04 , C07D235/06
CPC分类号： C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
摘要： Disclosed are compounds of the formula I, and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1 , R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
-
公开(公告)号：EP1673339B1
公开(公告)日：2013-07-03
申请号：EP04783028.6
申请日：2004-09-01
发明人： WALLACE, Eli , HURLEY, Brian , YANG, Hoon, Woon , LYSSIKATOS, Joseph , MARLOW, Allison, L. , BLAKE, Jim
IPC分类号： A61K31/42 , C07D261/20 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , C07D261/20
-
公开(公告)号：EP1663210A1
公开(公告)日：2006-06-07
申请号：EP04781809.1
申请日：2004-08-20
发明人： WALLACE, Eli, M. , LYSSIKATOS, Joseph, P. , MARLOW, Allison, L. , HURLEY, Brian, T. , KOCH, Kevin
IPC分类号： A61K31/4184 , C07D235/08
CPC分类号： C07D235/06 , C04B35/632 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12 , C07F9/65068 , C07F9/65586
摘要： Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9, and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
-
公开(公告)号：EP1482944A2
公开(公告)日：2004-12-08
申请号：EP03716498.5
申请日：2003-03-13
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4184 , C07D413/02 , C07D403/02 , C07D235/14
CPC分类号： C07D235/06 , C07D401/06 , C07D403/06
摘要： Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein W, t, R1, R2, R7, R9, R10, R11 and R12 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.027 秒)
