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公开(公告)号：EP3532475A2
公开(公告)日：2019-09-04
申请号：EP17793818.0
申请日：2017-10-26
IPC分类号： C07D471/22 , A61K31/519 , A61P35/00
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公开(公告)号：EP3700576A1
公开(公告)日：2020-09-02
申请号：EP18800437.8
申请日：2018-10-25
发明人： ZHAO, Qian , SPENCER, Stacey , JIANG, Yutong , HAAS, Julia , EARY, Charles Todd
IPC分类号： A61K47/36 , A61K47/38 , A61K31/00 , C07D471/22
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公开(公告)号：EP3205654B1
公开(公告)日：2019-01-02
申请号：EP17163978.4
申请日：2011-05-13
发明人： ANDREWS, Steven Wade , CONDROSKI, Kevin Ronald , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , SEO, Jeongbeob , YANG, Hong-Woon , ZHAO, Qian
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , C07D498/22 , C07D487/22 , C07D471/22
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4.发明授权SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS 有权取代的N-（1H-吲唑-4-基）咪唑并[1,2-a]吡啶-3-甲酰胺，为III型受体TYROSINKINASENHIBITOREN
公开(公告)号：EP2651939B1
公开(公告)日：2015-04-08
申请号：EP11808427.6
申请日：2011-12-13
发明人： BOYS, Mark Laurence , DELISLE, Robert Kirk , HICKEN, Erik James , KENNEDY, April L. , MARESKA, David A. , MARMSATER, Fredrik P. , MUNSON, Mark C. , NEWHOUSE, Brad , RAST, Bryson , RIZZI, James P. , RODRIGUEZ, Martha E. , TOPALOV, George T. , ZHAO, Qian
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06
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5.发明公开SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS 有权取代的N-（1H-吲唑-4-基）咪唑并[1,2-a]吡啶-3-甲酰胺，为III型受体TYROSINKINASENHIBITOREN
公开(公告)号：EP2651939A1
公开(公告)日：2013-10-23
申请号：EP11808427.6
申请日：2011-12-13
发明人： BOYS, Mark Laurence , DELISLE, Robert Kirk , HICKEN, Erik James , KENNEDY, April L. , MARESKA, David A. , MARMSATER, Fredrik P. , MUNSON, Mark C. , NEWHOUSE, Brad , RAST, Bryson , RIZZI, James P. , RODRIGUEZ, Martha E. , TOPALOV, George T. , ZHAO, Qian
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06
摘要： Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R
1 , R
2 , R
3 , R
4 , R
5 and R
6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.-
公开(公告)号：EP1660090B1
公开(公告)日：2012-11-21
申请号：EP04780990.0
申请日：2004-08-10
IPC分类号： A61K31/51 , A61K31/517 , A61K31/535 , C07D403/00 , C07D239/82
CPC分类号： C07D239/94 , C04B35/632 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14
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公开(公告)号：EP1879886A1
公开(公告)日：2008-01-23
申请号：EP06758821.0
申请日：2006-05-01
发明人： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , ALLEN, Shelley , LAIRD, Ellen , LYSSIKATOS, Joseph P. , ROBINSON, John E. , CORRETTE, Christopher P. , DELISLE, Robert Kirk , VOEGTLI, Walter Charles
IPC分类号： C07D417/04
CPC分类号： C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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8.发明公开MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF 有权MITOTISCHE KINESINHEMMER UND VERFAHREN ZU IHRER VERWENDUNG
公开(公告)号：EP1809280A2
公开(公告)日：2007-07-25
申请号：EP05819172.7
申请日：2005-10-18
发明人： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , LYSSIKATOS, Joseph P. , AICHER, Tom , LAIRD, Ellen , ROBINSON, John , ALLEN, Shelley
IPC分类号： A61K31/4245 , C07D417/00 , C07D413/00
CPC分类号： C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：EP3205654A1
公开(公告)日：2017-08-16
申请号：EP17163978.4
申请日：2011-05-13
发明人： ANDREWS, Steven Wade , CONDROSKI, Kevin Ronald , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , SEO, Jeongbeob , YANG, Hong-Woon , ZHAO, Qian
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , C07D498/22 , C07D487/22 , C07D471/22
CPC分类号： C07D498/22 , A61K31/519 , C07D471/22 , C07D487/04 , C07D487/22 , C07D519/00 , Y02A50/414
摘要： Compounds of Formula I:
and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R 2 , R 2a , R 3 , R 3a , and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.摘要翻译： 其中环A，环B，W，m，D，R2，R2a，R3，R3a和Z如本文所定义的式I化合物及其药学上可接受的盐为Trk激酶的抑制剂并且可用于治疗 疼痛，癌症，炎症，神经退行性疾病和某些传染病。
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公开(公告)号：EP2334677B1
公开(公告)日：2013-10-09
申请号：EP09791625.8
申请日：2009-08-18
发明人： ALLEN, Shelley , CELESTE, Laura L. , DAVIS, T. Gregg , DELISLE, Robert Kirk , GRESCHUK, Julie Marie , GROSS, Stefan, D. , HICKEN, Erik, James , JACKSON, Leila, J. , LYSSIKATOS, Joseph, P. , KALLAN, Nicholas C. , MARMSATER, Fredrik, P. , MUNSON, Mark, C. , PHENEGER, Jed , RAST, Bryson , ROBINSON, John, E. , SCHLACHTER, Stephen T. , TOPALOV, George T. , WRIGHT, A. Dale , ZHAO, Qian
IPC分类号： C07D471/04 , A61K31/47
CPC分类号： C07D471/04
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