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    HETERODIMERIC PROTEINS
    4.
    发明公开
    HETERODIMERIC PROTEINS 审中-公开

    公开(公告)号：EP3587448A1

    公开(公告)日：2020-01-01

    申请号：EP19175124.7

    申请日：2014-03-17

    申请人： Xencor, Inc.

    发明人： MOORE, Gregory ,  DESJARLAIS, John ,  RASHID, Rumana ,  BERNETT, Matthew J.

    IPC分类号： C07K16/06 ,  C07K16/28 ,  C07K16/46

    摘要： In one aspect, the present invention provides heterodimeric antibodies comprising a first monomer comprising a first heavy chain constant domain comprising a first variant Fc domain and a first antigen binding domain and a second monomer comprising a second heavy chain constant domain comprising a second variant Fc domain and a second antigen binding domain. In an additional aspect the heterodimeric antibody comprises a first monomer comprising a heavy chain comprising a first Fc domain and a single chain Fv region (scFv) that binds a first antigen, wherein the scFv comprises a charged scFv linker. The heterodimeric antibody further comprises a second monomer comprising a first heavy chain comprising a second Fc domain and a first variable heavy chain and a first light chain.