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公开(公告)号：EP1529045A2
公开(公告)日：2005-05-11
申请号：EP03785036.9
申请日：2003-08-08
发明人： WENSBO, David , XIN, Tao , STEFANAC, Tomislav , ARORA, Jalaj , EDWARDS, Louise , ISAAC, Methvin , SLASSI, Abdelmalik , STORMANN, Thomas, M. , MCLEOD, Donald, A. , KERS, Annika , MALMBERG, Johan , OSCARSSON, Karin , GYBACK, Helena , JOHANSSON, Martin , MINIDIS, Alexander , WALDMAN, Magnus , YNGVE, Ulrika , OSTERWALL, Christoffer
IPC分类号： C07D413/12
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
摘要： The present invention relates to new compounds of formula (I), a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy. In particular, there are compounds according to the present invention that are potent and selective for the mGluR Group I receptor and more particularly for mGluR5. Thus, it is expected that the compounds of the invention are well suited for the prevention and/or treatment of mGluR5 receptor-mediated disorders such as acute and chronic neurological and psychiatric disorders and chronic and acute pain disorders.
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2.发明公开5- (PHENYLISOXAZOLYLETHOXY) -TRIAZOL- 3 -YL SUBSTITUTED PYRIDINE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC OR PAIN DISORDERS 审中-公开5-（PHENYLISOXAZOLYLETHOXY）三唑-3- YLSUBSTITUIERTE吡啶用于治疗神经障碍，精神障碍，疼痛病症或化合物
公开(公告)号：EP1934209A1
公开(公告)日：2008-06-25
申请号：EP06803836.3
申请日：2006-09-20
申请人： Astra Zeneca AB
发明人： MINIDIS, Alexander , WENSBO, David , SLASSI, Abdelmalik , ISAAC, Methvin , ERICSSON, Caroline , PROFIR, Veronica , BERGSTROM, Per-Olov , EDWARDS, Louise , ARORA, Jalaj , XIN, Tao
IPC分类号： C07D413/14 , A61K31/00 , A61P1/04 , A61P25/00
CPC分类号： C07D413/14
摘要： The present invention is directed to novel compounds of formula (I) / (I1) / (III), their use in therapy and pharmaceutical compositions comprising said novel compounds.
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3.发明公开ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 有权更多的多环化合物及其作为METABO谷氨酸受体的拮抗剂
公开(公告)号：EP1723144A1
公开(公告)日：2006-11-22
申请号：EP05802855.6
申请日：2005-02-15
发明人： EDWARDS, Louise , ISAAC, Methvin , JOHANSSON, Martin , KERS, Annika , MALMBERG, Johan , MCLEOD, Donald , MINIDIS, Alexander , STAAF, Karin , SLASSI, Abdelmalik , STEFANAC, Tomislav , STORMANN, Thomas , WENSBO, David , XIN, Tao , ARORA, Jalaj
IPC分类号： C07D413/12 , C07D413/14 , C07D487/04 , A61K31/519 , A61P25/28 , C07D413/06
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
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4.发明公开SATURATED QUINOXALINE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS 审中-公开饱和喹喔啉及其作为配体的代谢型谷氨酸受体
公开(公告)号：EP1587796A1
公开(公告)日：2005-10-26
申请号：EP04705287.3
申请日：2004-01-26
发明人： GYBÄCK, Helena , JOHANSSON, Martin , MINIDIS, Alexander , NORDVALL, Gunnar , RABOISSON, Patrick , WENSBRO, David
IPC分类号： C07D241/44 , C07D241/38 , C07D491/04 , C07D241/52 , A61K31/498 , A61K31/4985 , A61P25/00 , C07C237/04 , C07F7/18
CPC分类号： C07D241/38 , C07D241/44 , C07D241/52 , C07D491/04
摘要： The present invention relates to new compounds of formula (I), wherein Q is a partially saturated ring or Nl-oxides, salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof and to the use of said compounds as metabotropic glutamate receptors ligands in therapy.
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