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1.发明公开ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 有权更多的多环化合物及其作为METABO谷氨酸受体的拮抗剂
公开(公告)号：EP1723144A1
公开(公告)日：2006-11-22
申请号：EP05802855.6
申请日：2005-02-15
发明人： EDWARDS, Louise , ISAAC, Methvin , JOHANSSON, Martin , KERS, Annika , MALMBERG, Johan , MCLEOD, Donald , MINIDIS, Alexander , STAAF, Karin , SLASSI, Abdelmalik , STEFANAC, Tomislav , STORMANN, Thomas , WENSBO, David , XIN, Tao , ARORA, Jalaj
IPC分类号： C07D413/12 , C07D413/14 , C07D487/04 , A61K31/519 , A61P25/28 , C07D413/06
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
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2.发明公开POLYHETEROCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 审中-公开聚杂环化合物及其作为METABO谷氨酸受体的拮抗剂
公开(公告)号：EP1716143A1
公开(公告)日：2006-11-02
申请号：EP05713792.9
申请日：2005-02-17
发明人： ARORA, Jalaj , EDWARDS, Louise, NPS Allelix Corp. , ISAAC, Methvin, NPS Allelix Corp. , KERS, Annika, AstraZeneca R & D Headquarters , STAAF, Karin, AstraZeneca R & D Headquarters , SLASSI, Abdelmalik, NPS Allelix Corp. , STEFANAC, Tomislav, NPS Allelix Corp. , WENSBO, David, AstraZeneca R & D Headquarters , XIN, Tao , HOLM, Björn
IPC分类号： C07D413/14 , A61K31/4545 , A61P25/00 , A61K31/5377 , A61K31/496 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, X5, X6, R1, R2, R3, m, n, and p are as defined as in formula (I), or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
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3.发明公开
公开(公告)号：EP1536790A2
公开(公告)日：2005-06-08
申请号：EP03749015.8
申请日：2003-08-08
发明人： MCLEOD, Donald, A. , KERS, Annika , MALMBERG, Johan , OSCARSSON, Karin , EDWARDS, Louise , ISAAC, Methvin , SLASSI, Abdelmalik , STORMANN, Thomas, M. , XIN, Tao , ARORA, Jalaj , WENSBO, David , STEFANAC; Tomislav
IPC分类号： A61K31/4245 , C07D271/06 , C07D271/10 , C07D261/08 , A61P25/00 , C07D271/07 , C07D271/113 , C07D261/14 , C07D413/10 , C07D413/06 , C07D413/04 , C07D413/14
CPC分类号： C07D271/06 , C07D261/08 , C07D261/14 , C07D271/07 , C07D271/107 , C07D271/113 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, R, R1, R2, R3, R4, R5, R6, R7, m, n, o, p and q are defined as in any one of claims 1 to 12, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy. It has been found that the compounds according to the present invention, or salts therof, exhibit a high degree of potency and selectivity for individual metabotropic glutamate receptor (mGluR) subtypes. In particular there are compounds according to the present invention that are potent and selective for the mGluR Group I receptor and more particularly for mGluR5. Thus, it is expected that the compounds of the invention are well suited for the prevention and/or treatment of mGluR5 receptor-mediated disorders such as acute and chronic neurological and psychiatric disorders and chronic and acute pain disorders.
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公开(公告)号：EP1581525A2
公开(公告)日：2005-10-05
申请号：EP03785076.5
申请日：2003-08-08
发明人： WENSBO, David , XIN, Tao , STEFANAC, Thomislav , ARORA, Jalaj , EDWARDS, Louise , ISAAC, Methvin , SLASSI, Abdelmalik
IPC分类号： C07D413/14 , C07D417/14 , A61K31/4245 , A61P25/00
CPC分类号： C07D413/14 , C07D413/04 , C07D417/04 , C07D417/14
摘要： The present invention relates to new compounds of formula I, wherein P Q X1 X2 X3 X4 X5 R R1 R2 R3 R4R5 G M1 M2 M3 m and n are defined as in formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
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公开(公告)号：EP1529045A2
公开(公告)日：2005-05-11
申请号：EP03785036.9
申请日：2003-08-08
发明人： WENSBO, David , XIN, Tao , STEFANAC, Tomislav , ARORA, Jalaj , EDWARDS, Louise , ISAAC, Methvin , SLASSI, Abdelmalik , STORMANN, Thomas, M. , MCLEOD, Donald, A. , KERS, Annika , MALMBERG, Johan , OSCARSSON, Karin , GYBACK, Helena , JOHANSSON, Martin , MINIDIS, Alexander , WALDMAN, Magnus , YNGVE, Ulrika , OSTERWALL, Christoffer
IPC分类号： C07D413/12
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
摘要： The present invention relates to new compounds of formula (I), a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy. In particular, there are compounds according to the present invention that are potent and selective for the mGluR Group I receptor and more particularly for mGluR5. Thus, it is expected that the compounds of the invention are well suited for the prevention and/or treatment of mGluR5 receptor-mediated disorders such as acute and chronic neurological and psychiatric disorders and chronic and acute pain disorders.
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6.发明授权ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 有权更多的多环化合物及其作为METABO谷氨酸受体的拮抗剂
公开(公告)号：EP1723144B1
公开(公告)日：2010-10-06
申请号：EP05802855.6
申请日：2005-02-15
申请人： AstraZeneca AB
发明人： EDWARDS, Louise , ISAAC, Methvin , JOHANSSON, Martin , KERS, Annika , MALMBERG, Johan , MCLEOD, Donald , MINIDIS, Alexander , STAAF, Karin , SLASSI, Abdelmalik , STEFANAC, Tomislav , STORMANN, Thomas , WENSBO, David , XIN, Tao , ARORA, Jalaj
IPC分类号： C07D413/12 , C07D413/14 , C07D487/04 , A61K31/519 , A61P25/28 , C07D413/06
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
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公开(公告)号：EP2134687A1
公开(公告)日：2009-12-23
申请号：EP08730937.3
申请日：2008-02-28
申请人： AstraZeneca AB
发明人： ARORA, Jalaj , ISAAC, Methvin , SLASSI, Abdelmalik , EDWARDS, Louise , NAIR, Satheesh , MA, Fupeng
IPC分类号： C07D213/61 , C07D213/84 , C07D213/85 , C07D241/24 , C07D295/192 , C07D401/12 , C07D405/12 , C07D417/12 , A61K31/496 , A61P25/00 , A61P25/18
CPC分类号： C07D213/61 , C07D213/84 , C07D213/85 , C07D241/24 , C07D295/192 , C07D401/12 , C07D405/12 , C07D417/12
摘要： Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof, wherein A, B, D, Ar1, Ar2, R2, R3, R4, a, m and n are defined in the specification, methods for the use thereof, processes for making and pharmaceutical compositions containing the same.
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公开(公告)号：EP1979320B1
公开(公告)日：2009-10-21
申请号：EP07716336.8
申请日：2007-01-05
申请人： AstraZeneca AB
IPC分类号： C07D211/70 , C07D213/30 , C07D213/61 , C07D213/74 , C07D213/85 , C07D233/54 , C07D239/26 , C07D241/12 , C07D277/24 , C07D295/10 , C07D295/14 , C07D233/16 , C07D401/12 , C07D409/12 , A61K31/506 , A61P25/18
CPC分类号： C07D295/108 , C07D211/70 , C07D213/30 , C07D213/61 , C07D213/74 , C07D213/85 , C07D233/64 , C07D239/26 , C07D241/12 , C07D277/24 , C07D295/155 , C07D333/16 , C07D401/12 , C07D409/12
摘要： The invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein Ar1, Ar2, A, X, Y, m, n and R1 to R5 are described in the specification.
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公开(公告)号：EP1979320A2
公开(公告)日：2008-10-15
申请号：EP07716336.8
申请日：2007-01-05
申请人： AstraZeneca AB
IPC分类号： C07D211/70 , C07D213/30 , C07D213/61 , C07D213/74 , C07D213/85 , C07D233/54 , C07D239/26 , C07D241/12 , C07D277/24 , C07D295/10 , C07D295/14 , C07D233/16 , C07D401/12 , C07D409/12 , A61K31/506 , A61P25/18
CPC分类号： C07D295/108 , C07D211/70 , C07D213/30 , C07D213/61 , C07D213/74 , C07D213/85 , C07D233/64 , C07D239/26 , C07D241/12 , C07D277/24 , C07D295/155 , C07D333/16 , C07D401/12 , C07D409/12
摘要： The invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein Ar1, Ar2, A, X, Y, m, n and R1 to R5 are described in the specification.
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