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公开(公告)号：EP1529045A2
公开(公告)日：2005-05-11
申请号：EP03785036.9
申请日：2003-08-08
发明人： WENSBO, David , XIN, Tao , STEFANAC, Tomislav , ARORA, Jalaj , EDWARDS, Louise , ISAAC, Methvin , SLASSI, Abdelmalik , STORMANN, Thomas, M. , MCLEOD, Donald, A. , KERS, Annika , MALMBERG, Johan , OSCARSSON, Karin , GYBACK, Helena , JOHANSSON, Martin , MINIDIS, Alexander , WALDMAN, Magnus , YNGVE, Ulrika , OSTERWALL, Christoffer
IPC分类号： C07D413/12
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
摘要： The present invention relates to new compounds of formula (I), a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy. In particular, there are compounds according to the present invention that are potent and selective for the mGluR Group I receptor and more particularly for mGluR5. Thus, it is expected that the compounds of the invention are well suited for the prevention and/or treatment of mGluR5 receptor-mediated disorders such as acute and chronic neurological and psychiatric disorders and chronic and acute pain disorders.
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公开(公告)号：EP2079730A1
公开(公告)日：2009-07-22
申请号：EP07804973.1
申请日：2007-09-25
申请人： Astra Zeneca AB
发明人： ISAAC, Methvin , SLASSI, Abdelmalik , EDWARDS, Louise , DOVE, Peter , XIN, Tao , STEFANAC, Tomislav
IPC分类号： C07D401/14 , C07D413/14 , A61K31/42 , A61P25/22 , A61P23/00
CPC分类号： C07D413/14 , C07D401/14
摘要： The present invention is directed to compounds of formula (I) Wherein R1 to R5, X and Z are further defined in the description. The invention also relates to processes for the preparation of the compounds and to intermediates used in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
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公开(公告)号：EP2027110A2
公开(公告)日：2009-02-25
申请号：EP07761250.5
申请日：2007-04-25
申请人： Astra Zeneca AB
IPC分类号： C07D401/14 , C07D413/14 , C07D403/04 , A61P25/00 , A61K31/4545 , A61K31/4406 , A61K31/4409
CPC分类号： C07D403/04 , C07D401/14 , C07D413/14
摘要： The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
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4.发明公开
公开(公告)号：EP2027128A2
公开(公告)日：2009-02-25
申请号：EP07797275.0
申请日：2007-04-25
申请人： Astra Zeneca AB
发明人： ISAAC, Methvin , SLASSI, Abdelmalik , EDWARDS, Louise , XIN, Tao , STEFANAC, Tomislav , DOVE, Peter , NÅGÅRD, Mats
IPC分类号： C07D487/04 , A61K31/4196 , A61P25/00
CPC分类号： C07D487/04
摘要： The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
摘要翻译： 本发明涉及新化合物，其制备方法，其在治疗中的用途以及包含该新化合物的药物组合物。
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5.发明公开ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 有权更多的多环化合物及其作为METABO谷氨酸受体的拮抗剂
公开(公告)号：EP1723144A1
公开(公告)日：2006-11-22
申请号：EP05802855.6
申请日：2005-02-15
发明人： EDWARDS, Louise , ISAAC, Methvin , JOHANSSON, Martin , KERS, Annika , MALMBERG, Johan , MCLEOD, Donald , MINIDIS, Alexander , STAAF, Karin , SLASSI, Abdelmalik , STEFANAC, Tomislav , STORMANN, Thomas , WENSBO, David , XIN, Tao , ARORA, Jalaj
IPC分类号： C07D413/12 , C07D413/14 , C07D487/04 , A61K31/519 , A61P25/28 , C07D413/06
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
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