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公开(公告)号：EP1561817A2
公开(公告)日：2005-08-10
申请号：EP05004454.4
申请日：2001-07-27
发明人： Berinstein, Neil , Tartaglia, James , Tine, John A. , Panicali, Dennis L. , Gritz, Linda , Schlom, Jeffrey
CPC分类号： A61K38/1709 , A61K39/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5256 , A61K2039/53 , C07K14/70503
摘要： The invention discloses immunogenic CEA agonist polypeptides/proteins comprising a modified epitope containing the amino acid sequence YLSGADLNL, nucleic acids coding therefor, vectors and/or cells comprising said nucleic acids, and mixtures and/or compositions thereof. Methods for eliciting or inducing CEA-specific immune responses utilizing the aforementioned agents are also disclosed.
摘要翻译： 本发明公开了包含含有氨基酸序列YLSGADLNL的修饰表位，编码其的核酸，包含所述核酸的载体和/或细胞以及其混合物和/或组合物的免疫原性CEA激动剂多肽/蛋白质。 还公开了利用上述药剂引发或诱导CEA特异性免疫应答的方法。
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公开(公告)号：EP1561817A3
公开(公告)日：2005-09-14
申请号：EP05004454.4
申请日：2001-07-27
发明人： Berinstein, Neil , Tartaglia, James , Tine, John A. , Panicali, Dennis L. , Gritz, Linda , Schlom, Jeffrey
CPC分类号： A61K38/1709 , A61K39/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5256 , A61K2039/53 , C07K14/70503
摘要： The invention discloses immunogenic CEA agonist polypeptides/proteins comprising a modified epitope containing the amino acid sequence YLSGADLNL, nucleic acids coding therefor, vectors and/or cells comprising said nucleic acids, and mixtures and/or compositions thereof. Methods for eliciting or inducing CEA-specific immune responses utilizing the aforementioned agents are also disclosed.
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3.发明公开Method of inducing and/or enhancing an immune response to tumor antigens 有权Verfahren zur Induzierung und / oder Verbesserung einer Immunreaktion auf Tumorantigene
公开(公告)号：EP1964573A2
公开(公告)日：2008-09-03
申请号：EP08009203.4
申请日：2000-10-20
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
摘要： An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.
摘要翻译： 公开了诱导和/或增强对肿瘤抗原的免疫应答的改进方法。 该方法包括将肿瘤抗原，其编码的核酸，包含所述核酸的载体和/或细胞或包含上述的疫苗施用于淋巴结位点。
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公开(公告)号：EP1728865A1
公开(公告)日：2006-12-06
申请号：EP06015673.4
申请日：1999-09-03
发明人： Gajewczyk, Diane M. , Persson, Roy , Yao, Fei-Long , Cao, Shi-Xian , Klein, Michel H. , Tartaglia, James , Moingeon, Philippe , Rovinski, Benjamin
IPC分类号： C12N15/37 , C12N15/86 , C07K14/025 , A61K48/00
CPC分类号： A61B5/055 , A61B5/0263 , A61B5/029 , A61B5/41 , A61K48/00 , A61K2039/51 , A61K2039/53 , C07K14/005 , C12N2710/20022 , C12N2710/20043 , Y10S977/804 , Y10S977/904 , Y10S977/916 , Y10S977/924
摘要： Vectors for DNA immunization against cervical cancer comprise a nucleic acid molecule encoding at least one none-toxic T-cell epitope of the E6 and/or E7 antigens of a strain of human papilloma virus (HPV) associated with cervical cancer, such as HPV-16, and a promoter operatively coupled to the nucleic acid molecule for expression of the nucleic acid molecule in a host to which the vector is administered.
摘要翻译： 用于针对子宫颈癌的DNA免疫的载体包含编码与子宫颈癌相关的人乳头状瘤病毒（HPV）的菌株的E6和/或E7抗原的至少一种无毒T细胞表位的核酸分子，例如HPV- 16和可操作地偶联于核酸分子的启动子，用于在施用载体的宿主中表达核酸分子。
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