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1.发明授权COMPOSITIONS UTILISABLES POUR REGULER L'ACTIVITE DE LA PARKINE 有权ZUR STEUERUNG DERPARKINAKTIVITÄTBRAUCHBARE ZUSAMMENSETZUNGEN
公开(公告)号：EP1259606B1
公开(公告)日：2010-04-28
申请号：EP01907820.3
申请日：2001-02-15
发明人： KOUTNIKOVA, Hana , BRICE, Alexis , FOURNIER, Alain , PRADIER, Laurent , PRADES, Catherine , ARNOULD-REGUIGNE, Isabelle , ROSIER-MONTUS, Marie-Françoise , CORTI, Olga
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
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2.发明公开ANIMAUX TRANSGENIQUES PRESENTANT LES TROUBLES MAJEURS LIES A LA MALADIE D'ALZHEIMER 有权与阿尔茨海默病相关的GO相关的严重病理状态转基因动物
公开(公告)号：EP1670309A1
公开(公告)日：2006-06-21
申请号：EP04787459.9
申请日：2004-09-27
申请人： Aventis Pharma S.A.
发明人： CASAS LOUZAO, Caty , BENOIT, Patrick , PRADIER, Laurent , TREMP, Gunter , ITIER, Jean-Michel , BLANCHARD-BREGEON, Véronique
IPC分类号： A01K67/027 , C07K14/47 , G01N33/50 , C12N15/90 , C12N5/10 , C12N15/12 , C12N15/63 , C12Q1/02
CPC分类号： C07K14/4711 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2227/107 , A01K2267/0312 , C12N15/8509 , C12N2517/02
摘要： The invention relates to non-human transgenic animals with serious disorders related to Alzheimer's disease. The animals can be used for the discovery of compounds for the treatment of Alzheimer's disease.
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公开(公告)号：EP1259606A2
公开(公告)日：2002-11-27
申请号：EP01907820.3
申请日：2001-02-15
发明人： KOUTNIKOVA, Hana , BRICE, Alexis , FOURNIER, Alain , PRADIER, Laurent , PRADES, Catherine , ARNOULD-REGUIGNE, Isabelle , ROSIER-MONTUS, Marie-Françoise , CORTI, Olga
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The invention concerns novel compounds and their uses, in particular pharmaceutical, diagnostic or as pharmacological targets. More particularly, the invention concerns a novel protein, called PAP1, and novel peptides and compounds capable of modulating at least partially parkin gene activity.
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公开(公告)号：EP1639139B1
公开(公告)日：2011-07-27
申请号：EP04767370.2
申请日：2004-06-17
申请人： Aventis Pharma S.A.
发明人： MACE, Sandrine , RICARD, Sylvain , COUSIN, Emmanuelle , PRADIER, Laurent , BENAVIDES, Jesus , DELEUZE, Jean-François
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/156
摘要： The invention relates to methods for the diagnosis or prognosis of Alzheimer's disease in an individual. An inventive method has at least one step for detecting the presence or the absence of the minority allele of polymorphism rs908832 of gene ABCA2. The presence of the minority allele of polymorphism rs908832 of gene ABCA2 indicates that the individual can be afflicted with Alzheimer's disease or is presently at increased risk of developing Alzheimer's disease.
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5.发明授权ANIMAL TRANSGENIQUE EXPRIMANT UNE FORME MULTI-MUTEE DE LA PRESENILINE 1 有权转基因动物WHICH ON MULTIPLE突变型早1明示
公开(公告)号：EP1255437B1
公开(公告)日：2010-04-14
申请号：EP00964344.6
申请日：2000-09-22
申请人： Aventis Pharma S.A.
IPC分类号： A01K67/027 , C07K14/47 , C12N5/10 , A61K49/00 , G01N33/50
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , C07K14/4711
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公开(公告)号：EP1639139A2
公开(公告)日：2006-03-29
申请号：EP04767370.2
申请日：2004-06-17
申请人： Aventis Pharma S.A.
发明人： MACE, Sandrine , RICARD, Sylvain , COUSIN, Emmanuelle , PRADIER, Laurent , BENAVIDES, Jesus , DELEUZE, Jean-François
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/156
摘要： The invention relates to methods for the diagnosis or prognosis of Alzheimer's disease in an individual. An inventive method has at least one step for detecting the presence or the absence of the minority allele of polymorphism rs908832 of gene ABCA2. The presence of the minority allele of polymorphism rs908832 of gene ABCA2 indicates that the individual can be afflicted with Alzheimer's disease or is presently at increased risk of developing Alzheimer's disease.
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7.发明公开ANIMAL TRANSGENIQUE EXPRIMANT UNE FORME MULTI-MUTEE DE LA PRESENILINE 1 有权转基因动物WHICH ON MULTIPLE突变型早1明示
公开(公告)号：EP1255437A1
公开(公告)日：2002-11-13
申请号：EP00964344.6
申请日：2000-09-22
申请人： Aventis Pharma S.A.
IPC分类号： A01K67/027 , C07K14/47 , C12N5/10 , A61K49/00 , G01N33/50
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , C07K14/4711
摘要： The invention concerns the field of transgenic animal models and more particularly, animal models of Alzheimer disease. The invention relates to a transgenic animal expressing a multiple mutated form of presenilin 1 and enabling to detect an apoptotic phenomenon in a renewable peripheral tissue.
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8.发明公开
公开(公告)号：EP1021533A1
公开(公告)日：2000-07-26
申请号：EP98946534.9
申请日：1998-09-30
申请人： Aventis Pharma S.A.
IPC分类号： C12N15/12 , C07K14/47 , C07K16/18 , A61K38/17 , C12Q1/68 , A61K39/395 , A61K31/70 , G01N33/68
CPC分类号： C07K14/4711 , A61K38/00 , A61K48/00 , C12N2799/021
摘要： The invention concerns novel nucleotide and peptide sequences, and their pharmaceutical use. More particularly, it concerns nucleic acids coding for proteins capable of interacting with presenilins.
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9.发明授权PEPTIDES CAPABLES D'INHIBER L'INTERACTION ENTRE LES PRESENILINES ET LE PEPTIDE BETA-AMYLOIDE OU SON PRECURSEUR 有权肽相互作用的早老和β淀粉样肽或他的PRE INHIBIT BETWEEN
公开(公告)号：EP1025121B1
公开(公告)日：2011-08-24
申请号：EP98951547.3
申请日：1998-10-23
申请人： Aventis Pharma S.A.
CPC分类号： G01N33/502 , A61K38/00 , A61K48/00 , C07K14/4711 , C07K2319/02 , C12N2799/021 , G01N33/5008 , G01N33/542 , G01N33/6896 , G01N2333/4709 , G01N2500/02
摘要： The invention concerns novel peptide and nucleotide sequences, and their pharmaceutical use. More particularly, the invention concerns novel polypeptides capable of inhibiting at least partially the interaction between presenilin 1 or presenilin 2 and the β-amyloid peptide precursor and/or the β-amyloid peptide. The invention also concerns the preparation of in vitro tests for detecting molecules and in particular molecules capable of inhibiting said interaction.
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10.发明授权ANIMAUX TRANSGENIQUES PRESENTANT LES TROUBLES MAJEURS LIES A LA MALADIE D'ALZHEIMER 有权与阿尔茨海默病相关的GO相关的严重病理状态转基因动物
公开(公告)号：EP1670309B1
公开(公告)日：2010-06-23
申请号：EP04787459.9
申请日：2004-09-27
申请人： Aventis Pharma S.A.
发明人： CASAS LOUZAO, Caty , BENOIT, Patrick , PRADIER, Laurent , TREMP, Gunter , ITIER, Jean-Michel , BLANCHARD-BREGEON, Véronique
IPC分类号： A01K67/027 , C07K14/47 , G01N33/50 , C12N15/90 , C12N5/10 , C12N15/12 , C12N15/63 , C12Q1/02
CPC分类号： C07K14/4711 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2227/107 , A01K2267/0312 , C12N15/8509 , C12N2517/02
摘要： The invention relates to non-human transgenic animals with serious disorders related to Alzheimer's disease. The animals can be used for the discovery of compounds for the treatment of Alzheimer's disease.
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