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1.发明授权COMPOSITIONS UTILISABLES POUR REGULER L'ACTIVITE DE LA PARKINE 有权ZUR STEUERUNG DERPARKINAKTIVITÄTBRAUCHBARE ZUSAMMENSETZUNGEN
公开(公告)号：EP1259606B1
公开(公告)日：2010-04-28
申请号：EP01907820.3
申请日：2001-02-15
发明人： KOUTNIKOVA, Hana , BRICE, Alexis , FOURNIER, Alain , PRADIER, Laurent , PRADES, Catherine , ARNOULD-REGUIGNE, Isabelle , ROSIER-MONTUS, Marie-Françoise , CORTI, Olga
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
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公开(公告)号：EP0672150B1
公开(公告)日：2007-05-30
申请号：EP93913176.9
申请日：1993-06-23
申请人： Aventis Pharma S.A.
发明人： FLEER, Reinhard , FOURNIER, Alain , YEH, Patrice
CPC分类号： C12N15/815 , C12N9/48 , C12N9/60
摘要： Yeasts of the genus (Kluyveromyces) having one or more genetic modifications of at least one gene encoding a protease, said gene reducing or modifying the proteolytic activity of said yeasts. The invention also concerns the use of said yeasts as host cell for the secretion of recombinant proteins.
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3.发明公开
公开(公告)号：EP1021533A1
公开(公告)日：2000-07-26
申请号：EP98946534.9
申请日：1998-09-30
申请人： Aventis Pharma S.A.
IPC分类号： C12N15/12 , C07K14/47 , C07K16/18 , A61K38/17 , C12Q1/68 , A61K39/395 , A61K31/70 , G01N33/68
CPC分类号： C07K14/4711 , A61K38/00 , A61K48/00 , C12N2799/021
摘要： The invention concerns novel nucleotide and peptide sequences, and their pharmaceutical use. More particularly, it concerns nucleic acids coding for proteins capable of interacting with presenilins.
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4.发明公开
公开(公告)号：EP1807697A1
公开(公告)日：2007-07-18
申请号：EP05812049.4
申请日：2005-10-24
申请人： Aventis Pharma S.A.
发明人： FOURNIER, Alain , BEHRENS, Ralf , BANDIERA, Silvio
CPC分类号： C12N15/1055
摘要： The invention relates to a novel double hybrid system and to the uses thereof. This system provides, in particular, a tool that enables the detection of the interruption of a protein-protein interaction. The developed system uses transcription interference as a mechanism for detecting a breaking up of interacting protein pairs. The developed double hybrid system can be applied to the screening of molecules enabling the detection of molecules breaking up a protein-protein interaction as well as enabling the identification of alleles lacking in the interaction of proteins involved in the protein-protein interactions.
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5.发明授权PROCEDE DE PRODUCTION DE PROTEINES RECOMBINANTES ET CELLULES HOTES UTILISEES 失效方法用于生产和ENSURE重组蛋白中的宿主细胞
公开(公告)号：EP0592574B1
公开(公告)日：2003-09-17
申请号：EP92915114.0
申请日：1992-06-30
申请人： Aventis Pharma S.A.
发明人： FLEER, Reinhard , FOURNIER, Alain , YEH, Patrice
CPC分类号： C12N15/01 , C07K14/76 , C12N15/815
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公开(公告)号：EP1259606A2
公开(公告)日：2002-11-27
申请号：EP01907820.3
申请日：2001-02-15
发明人： KOUTNIKOVA, Hana , BRICE, Alexis , FOURNIER, Alain , PRADIER, Laurent , PRADES, Catherine , ARNOULD-REGUIGNE, Isabelle , ROSIER-MONTUS, Marie-Françoise , CORTI, Olga
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The invention concerns novel compounds and their uses, in particular pharmaceutical, diagnostic or as pharmacological targets. More particularly, the invention concerns a novel protein, called PAP1, and novel peptides and compounds capable of modulating at least partially parkin gene activity.
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公开(公告)号：EP1144651A1
公开(公告)日：2001-10-17
申请号：EP00900608.1
申请日：2000-01-19
申请人： Aventis Pharma S.A.
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention concerns the field of biology and the regulation of the cell cycle. More particularly, the invention concerns polypeptides derived from the human JNK3 protein, their variants, the corresponding nucleotide sequences, and their uses.
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公开(公告)号：EP0658203B1
公开(公告)日：2003-07-23
申请号：EP93919067.4
申请日：1993-08-16
申请人： Aventis Pharma S.A.
发明人： TANNER, Widmar , STRAHL-BOLSINGER, Sabine c/o Philipp Strahl , FLEER, Reinhard , FOURNIER, Alain
CPC分类号： C12N9/1051 , C12N15/80 , C12N15/81
摘要： This invention relates to improved fungal cells and methods for producing recombinant products of improved quality and in high yields. More specifically, the present invention relates to fungal cells carrying specific modifications within their DNA sequences which cause them to exhibit at least a reduced capacity for O-glycosylating homologous and/or heterologous proteins, and the use of these cells as host cells to produce high yields of recombinant products.
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9.发明授权
公开(公告)号：EP1807697B1
公开(公告)日：2009-10-21
申请号：EP05812049.4
申请日：2005-10-24
申请人： Aventis Pharma S.A.
发明人： FOURNIER, Alain , BEHRENS, Ralf , BANDIERA, Silvio
CPC分类号： C12N15/1055
摘要： The invention relates to a novel double hybrid system and to the uses thereof. This system provides, in particular, a tool that enables the detection of the interruption of a protein-protein interaction. The developed system uses transcription interference as a mechanism for detecting a breaking up of interacting protein pairs. The developed double hybrid system can be applied to the screening of molecules enabling the detection of molecules breaking up a protein-protein interaction as well as enabling the identification of alleles lacking in the interaction of proteins involved in the protein-protein interactions.
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公开(公告)号：EP1257642B1
公开(公告)日：2008-11-26
申请号：EP01907727.0
申请日：2001-02-07
申请人： Aventis Pharma S.A.
发明人： MAURY, Isabelle , MERCKEN, Luc , FOURNIER, Alain
摘要： The invention concerns novel compounds and their pharmaceutical, diagnostic use or as pharmacological target. More particularly, it concerns the identification of partners of FE65 and the use thereof, or any compound capable of modulating, at least partly, their interaction with FE65 to regulate FE65 activity, and in particular the phenomenon of intracellular transport or of APP endocytosis.
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