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1.发明公开VERFAHREN ZUR HERSTELLUNG VON 1-SUBSTITUIERTEN 5-CHLOR-4METHYLPYRAZOLEN 有权用于生产1-取代5-氯4METHYLPYRAZOLEN
公开(公告)号：EP1320527A1
公开(公告)日：2003-06-25
申请号：EP01983513.1
申请日：2001-09-28
IPC分类号： C07D231/16 , C07D231/14 , C07D231/20
CPC分类号： C07D231/16 , C07D231/22
摘要： The invention relates to a method for producing 1-substituted 5-chloro-4-methyl pyrazoles of general formula (I) wherein R has the designated cited in claim 1. Said method reacts 4-methyl pyrazole of general formula (II) with chlorine, separating the mixture obtained from mono and dichlorinated products, by means of distillation subsequently dehalogenizing the dichlorinated compound to obtain compound II and re-introduction into the reaction with chlorine.
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2.发明公开VERFAHREN ZUR HERSTELLUNG VON 4-AMINO-5-CHLOR-1-PHENYLPYRIDAZINON-(6) 有权用于生产4-氨基-5-氯-1- PHENYLPYRIDAZINON
公开(公告)号：EP1165520A1
公开(公告)日：2002-01-02
申请号：EP00912664.0
申请日：2000-03-30
IPC分类号： C07D237/22
CPC分类号： C07D237/22
摘要： The invention relates to a method for producing 4-amino-5-chloro-1-phenyl pyridazinone-(6) by reacting 4,5-dichloro-1-phenyl pyridazinone-(6) with aqueous ammonia in the presence of a catalyst. According to the invention, a catalyst is used which is soluble in the aqueous alkaline reaction medium but which is, however, essentially insoluble in the reaction mixture that is acidically regulated after the 4-amino-5-chloro-1-phenyl pyridazinone-(6) has been removed. The inventive method makes it possible, in a simple manner, to recover and reuse the catalyst.
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3.发明公开VERFAHREN ZUR HERSTELLUNG VON 3-ISOPROPYL-1H-2, 1,3-BENZOTHIADIAZIN-4 (3H)-ON-2,2-DIOXID 失效PROCESS FOR的3-异丙基-1H-2-，1,3-苯并噻二嗪-4（3H） - 酮-2,2-二氧化物的制备
公开(公告)号：EP1005462A1
公开(公告)日：2000-06-07
申请号：EP98942624.2
申请日：1998-07-25
发明人： MERKLE, Hans, Rupert , WÖRZ, Otto , FRETSCHNER, Erich , HANSEN, Hanspeter , MÜLLER, Albrecht , BENZ, Kurt
IPC分类号： C07D285/16
CPC分类号： C07D285/16
摘要： The invention relates to a method for the production of 3-isopropyl-1H-2,1,3-benzothiazine-4(3H)-one-2,2-dioxide (I) or its salt. The method is characterized in that anthranilic acid isopropylamide (II) is reacted simultaneously with sulphur trioxide or chlorosulphonic acid in the presence of an organic base, or with sulphur trioxide adducts on organic bases, and phosphoroxychloride at 50 °C until reflux temperature, and then optionally transformed into their salts.
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4.发明授权VERFAHREN ZUR HERSTELLUNG FESTER, FREIFLIESSENDER WASSERLÖSLICHER SALZE VON ARYLOXI-C 1-C 4-ALKANCARBONSÄUREN 失效方法用于生产芳-C1-C4链烷酸SOLID，自由流动的水发件人盐类
公开(公告)号：EP0799177B1
公开(公告)日：2000-04-05
申请号：EP95941709.8
申请日：1995-12-13
发明人： MERKLE, Hans, Rupert , BRENNER, Karl, Siegfried , FRETSCHNER, Erich , SCHÖNHERR, Michael , VAN GASTEL, Anne
CPC分类号： C07C51/412 , A01N39/02 , A01N39/04 , A01N43/88 , A01N37/40 , A01N25/12 , A01N2300/00
摘要： A process is disclosed for preparing solid, free-flowing water-soluble salts of aryloxy-C1-C4-alkane carboxylic acids. Aryloxy-C1-C4-alkane carboxylic acids are reacted with a salt-forming base. Salts are formed in the melt in the presence or absence of an entrainer suitable for causing azeotropic water separation or in a solution in the presence of an entrainer suitable for causing azeotropic water separation. The entrainer is removed from the reaction mixture during or after the reaction and the solid salts are then isolated in the usual manner.
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公开(公告)号：EP0804405B1
公开(公告)日：1999-04-07
申请号：EP96900560.2
申请日：1996-01-04
IPC分类号： C07C53/19 , C07B57/00 , C07C51/09 , C07C51/487
摘要： The present invention relates to a process for producing optically active 2-halogen propionic acids in which the corresponding optically active 2-halogen propionic acid alkyl ester is reacted at high temperature with a carboxylic acid in a transacylation reaction to form the optically active 2-halogen propionic acid and the carboxylic acid alkyl ester and the optically active 2-halogen propionic acid is separated from the reaction mixture. The optically active products of the process are important intermediate products for the production of plant protection agents and pharmaceuticals.
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6.发明公开VERFAHREN ZUR HERSTELLUNG VON ALKALIMETALLSALZEN UND ERDALKALIMETALLSALZEN VON ARYLOXY-C1-C4-ALKANCARBONSÄUREN 失效用于生产碱金属盐和芳氧基-C 1 -C 4 - 链烷羧酸的碱土
公开(公告)号：EP0906264A1
公开(公告)日：1999-04-07
申请号：EP97925047.0
申请日：1997-06-05
发明人： MERKLE, Hans, Rupert , FRETSCHNER, Erich , HOFMANN, Jürgen , JÄGER, Karl-Friedrich , DIENER, Ralph , HÄRTL, Axel, Paul , SCHÖNHERR, Michael
CPC分类号： C07C51/412 , C07C59/68
摘要： A process for the production of alkaline metal salts and earth alkali metal salts of aryloxy-C1-C4-alkane carboxylic acids by reacting the basic aryloxy-C1-C4-alkane carboxylic acids with alkaline metal bases or earth alkali metal bases in the melt, by extruding a mixture of the aryloxy-C1-C4-alkane carboxylic acid and an at least stoichiometric quantity of an alkaline metal base or an earth alkali metal base, which are partially or completely converted in the reaction conditions into volatile substances. The invention also concerns the extrudates thus obtainable and the use of the extrudates which contain an aryloxy-C1-C4-alkane carboxylic acid with herbicidal action to combat undesired plant growth.
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7.发明公开VERFAHREN ZUR HERSTELLUNG VON 1,2-DIMETHYL-3,5-DIARYL-PYRAZOLIUM-METHYLSULFATEN 失效PROCESS FOR 1,2-二甲基-3,5-二芳基吡唑甲基硫酸盐的制备
公开(公告)号：EP0843665A1
公开(公告)日：1998-05-27
申请号：EP96927616.0
申请日：1996-07-26
IPC分类号： C07D231
CPC分类号： C07D231/12
摘要： The invention concerns a method of preparing 1,2-dimethyl-3,5-diarylpyrazolium methylsulphates of general formula (I) in which R?1 and R2¿, independently of each other, may be hydrogen, C¿1?-C4 alkyl, C3-C8 cycloalkyl, C1-C4 alkoxy, halogen, nitro C1-C4 haloalkyl, aryl or other substituents which are inert under the conditions of the reaction. The method calls for 1-methyl-3,5-diarylpyrazoles of general formula (II), in which R?1 and R2¿ are as defined above, to be reacted at elevated temperatures with a) methanol and SO¿3?, b) methanol and sulphuric acid and/or c) methanol and methylsulphuric acid.
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公开(公告)号：EP0804405A1
公开(公告)日：1997-11-05
申请号：EP96900560.0
申请日：1996-01-04
摘要： The present invention relates to a process for producing optically active 2-halogen propionic acids in which the corresponding optically active 2-halogen propionic acid alkyl ester is reacted at high temperature with a carboxylic acid in a transacylation reaction to form the optically active 2-halogen propionic acid and the carboxylic acid alkyl ester and the optically active 2-halogen propionic acid is separated from the reaction mixture. The optically active products of the process are important intermediate products for the production of plant protection agents and pharmaceuticals.
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9.发明公开VERFAHREN ZUR HERSTELLUNG FESTER, FREIFLIESSENDER WASSERLÖSLICHER SALZE VON ARYLOXI-C 1-C 4-ALKANCARBONSÄUREN 失效方法用于生产芳-C1-C4链烷酸SOLID，自由流动的水发件人盐类
公开(公告)号：EP0799177A1
公开(公告)日：1997-10-08
申请号：EP95941709.0
申请日：1995-12-13
发明人： MERKLE, Hans, Rupert , BRENNER, Karl, Siegfried , FRETSCHNER, Erich , SCHÖNHERR, Michael , VAN GASTEL, Anne
CPC分类号： C07C51/412 , A01N39/02 , A01N39/04 , A01N43/88 , A01N37/40 , A01N25/12 , A01N2300/00
摘要： A process is disclosed for preparing solid, free-flowing water-soluble salts of aryloxy-C1-C4-alkane carboxylic acids. Aryloxy-C1-C4-alkane carboxylic acids are reacted with a salt-forming base. Salts are formed in the melt in the presence or absence of an entrainer suitable for causing azeotropic water separation or in a solution in the presence of an entrainer suitable for causing azeotropic water separation. The entrainer is removed from the reaction mixture during or after the reaction and the solid salts are then isolated in the usual manner.
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公开(公告)号：EP0715622A1
公开(公告)日：1996-06-12
申请号：EP94925456.0
申请日：1994-08-13
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： A process is disclosed for preparing pyrazole and its derivatives having formula (I), in which the residues R?1, R2, R3 and R4¿ stand for hydrogen, halogen, nitro, carboxyl, sulfonyl or C-organic residues, from alpha,beta-unsaturated carbonyl compounds having formula (II) and from hydrazine or hydrazine derivatives having formula (III). The process is characterised in that an alpha,beta-unsaturated carbonyl compound having formula (II) is at first reacted without additional diluting agents with hydrazine or a hydrazine derivative having formula (III), and the thus obtained reaction mixture is reacted in an additional reaction step with a mixture of sulphuric acid and iodine or a iodine- or hydrogen iodide-relasing compound.
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