公开(公告)号：EP2245139A1

公开(公告)日：2010-11-03

申请号：EP09709947.7

申请日：2009-02-16

申请人： BASF Beauty Care Solutions France SAS ,  University Claude Bernard Lyon I ,  Centre National de la Recherche Scientifique (C.N.R.S) ,  Hospices Civils de Lyon

发明人： DAMOUR, Odile ,  BECHETOILLE, Nicolas ,  ANDRE, Valérie

IPC分类号： C12N5/06 ,  C12N5/08 ,  C12M3/00 ,  A61L27/26 ,  A61L27/38 ,  A61L27/56

CPC分类号： C12N5/0068 ,  A61F2/142 ,  A61L27/3804 ,  A61L27/3839 ,  C12N5/0621 ,  C12N2533/54 ,  C12N2533/70 ,  C12N2533/72

摘要： The invention relates to a model of reconstructed cornea, which may be used especially in tissue engineering, to a biomaterial that may be used for preparing a reconstructed cornea, and also to a culture device allowing better reproducibility of the cultures of the model of reconstructed cornea.

公开(公告)号：EP1948128A2

公开(公告)日：2008-07-30

申请号：EP06831309.7

申请日：2006-10-26

申请人： BASF Beauty Care Solutions France SAS ,  Centre National de la Recherche Scientifique ,  University Claude Bernard Lyon I

发明人： BOUEZ, Charbel ,  GLEYZAL, Claudine ,  ORLY, Isabelle ,  ANDRE, Valérie ,  SOMMER, Pascal ,  REYMERMIER, Corinne ,  DAMOUR, Odile ,  PERRIER, Eric

IPC分类号： A61K8/97 ,  G01N33/68 ,  G01N33/573 ,  C12Q1/68 ,  A61P17/06 ,  A61P17/00 ,  A61P35/00 ,  A61P37/06 ,  A61K36/48 ,  A61K36/17 ,  A61K36/185 ,  A61K36/54

CPC分类号： A61K8/97 ,  A61K9/0014 ,  A61K36/17 ,  A61K36/185 ,  A61K36/45 ,  A61K36/48 ,  A61K36/54 ,  A61K36/77 ,  A61K2800/596 ,  A61K2800/70 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/08 ,  G01N33/5011 ,  A61K2300/00

摘要： The invention concerns a substance for restoring normal co-expression and interaction between LOX and NRAGE proteins. In particular, the invention concerns the use of an effective amount of at least one substance modulating the expression and/or the activity of LOX having the sequence ID N°1 and/or modulating the expression and/or the activity of NRAGE having the sequence ID N°2 for making a composition for modulating the interaction between the LOX and NRAGE proteins so as to regulate the balance between the phenomena of proliferating cells, of differentiation and apoptosis, in particular in cases where the interaction between LOX and NRAGE proteins is absent or altered. The invention enables in particular skin aging, lichen planus, a graft-versus-host reaction disease, an eczema, a psoriasis, and a cancer, in particular an epithelial cancer, particularly an epithelial skin cancer, of basocellular type, or of spinocellular type to prevented or treated.

公开(公告)号：EP1853695A2

公开(公告)日：2007-11-14

申请号：EP06820794.3

申请日：2006-01-26

申请人： BASF Beauty Care Solutions France SAS ,  Centre National de la Recherche Scientifique ,  University Claude Bernard Lyon I

发明人： PERRIER, Eric ,  DAMOUR, Odile ,  ANDRE, Valerie

IPC分类号： C12M1/22

CPC分类号： C12M25/04 ,  C12M23/12 ,  C12M23/20 ,  C12M23/46 ,  C12M25/14 ,  C12M37/00 ,  C12M41/48

摘要： The invention relates to a cell culture device. This cell culture device (100), intended for receiving cells with their culture medium, is characterised in that it contains at least one cell-supporting layer of porous material, this layer being obtained by dehydration of an aqueous gel which is poured directly either into said well bottom (110-111), or into the bottom of a cradle or insert (150) of a size which is adapted for being insertable into the volume of the well. The invention enables a culture to be made which can be automated.

公开(公告)号：EP1948128B1

公开(公告)日：2017-03-15

申请号：EP06831309.7

申请日：2006-10-26

申请人： BASF Beauty Care Solutions France SAS ,  Centre National de la Recherche Scientifique ,  Université Claude Bernard Lyon I

发明人： BOUEZ, Charbel ,  GLEYZAL, Claudine ,  ORLY, Isabelle ,  ANDRE, Valérie ,  SOMMER, Pascal ,  REYMERMIER, Corinne ,  DAMOUR, Odile ,  PERRIER, Eric

IPC分类号： A61Q19/08 ,  A61K36/77 ,  A61K8/97 ,  G01N33/68 ,  G01N33/573 ,  C12Q1/68 ,  A61P17/06 ,  A61P17/00 ,  A61P35/00 ,  A61P37/06 ,  A61K36/48 ,  A61K36/17 ,  A61K36/185 ,  A61K36/54

CPC分类号： A61K8/97 ,  A61K9/0014 ,  A61K36/17 ,  A61K36/185 ,  A61K36/45 ,  A61K36/48 ,  A61K36/54 ,  A61K36/77 ,  A61K2800/596 ,  A61K2800/70 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/08 ,  G01N33/5011 ,  A61K2300/00