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    A process for the preparation of 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide
    5.
    发明公开
    A process for the preparation of 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide 有权
    Verfahren zur Herstellung von 10,11-二氢-10-氧代-5h-二苯并[b，f]氮杂-5-甲酰胺

    公开(公告)号：EP1958938A2

    公开(公告)日：2008-08-20

    申请号：EP08075527.5

    申请日：2002-05-22

    申请人： BIAL - Portela & Ca., S.A.

    发明人： Learmonth, David Alexander

    IPC分类号： C07D223/22

    CPC分类号： C07D491/04 ,  C07D223/22

    摘要： A process for the preparation of 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide (2) from 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (1), comprising oxidising 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (1) by reaction with peroxyacetic acid in the presence of a metal catalyst in a substantially inert solvent.

    摘要翻译： 由10,11-二氢-10-羟基-5H-二苯并[b，f]制备10,11-二氢-10-氧代-5H-二苯并[b，f /氮杂-5-甲酰胺（2） /吖庚因-5-甲酰胺（1），其包括在金属催化剂存在下与过氧乙酸反应氧化10,11-二氢-10-羟基-5H-二苯并/ b，f /氮杂-5-甲酰胺（1） 在基本惰性的溶剂中。

    Asymmetric catalytic reduction of oxcarbazepine
    7.
    发明授权
    Asymmetric catalytic reduction of oxcarbazepine 有权
    不对称催化还原奥卡西平

    公开(公告)号：EP2319836B1

    公开(公告)日：2015-11-25

    申请号：EP11152286.8

    申请日：2006-04-21

    申请人： Bial-Portela & CA, S.A.

    发明人： Learmonth, David Alexander ,  Grasa, Gabriela Alexandra ,  Zanotti-Gerosa, Antonio

    IPC分类号： C07D223/22

    CPC分类号： C07D223/28 ,  A61K31/55 ,  C07D223/22

    摘要： A process for preparing (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide or (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide, by reduction of oxcarbazepine in the presence of a catalyst and a hydride source is disclosed. The catalyst is prepared from a combination of [RuX 2 (L)] 2 wherein X is chlorine, bromine or iodine, and L is an aryl or aryl-aliphatic ligand, with a ligand of formula (A) or formula (B): wherein R 1 is chosen from C 1-6 alkoxy and C 1-6 alkyl, n is a number from 0 to 5, and when n is a number from 2 to 5, R 1 can be the same or different, and R 2 is alkyl, substituted alkyl, aryl, substituted aryl, alkaryl or substituted alkaryl. The hydride source is either NR 3 R 4 R 5 and formic acid, [R 3 R 4 R 5 NH][OOCH] and optionally formic acid, or [M][OOCH] x and formic acid, wherein R 3 , R 4 and R 5 are C 1-6 alkyl, M is an alkali metal or alkaline earth metal and x is 1 or 2. A pH from 6.5 to 8 is maintained during the process.